Featured Publications
Pulmonary Capillary Wedge Pressure Patterns During Exercise Predict Exercise Capacity and Incident Heart Failure
Eisman A, Shah R, Dhakal B, Pappagianopoulos P, Wooster L, Bailey C, Cunningham T, Hardin K, Baggish A, Ho J, Malhotra R, Lewis G. Pulmonary Capillary Wedge Pressure Patterns During Exercise Predict Exercise Capacity and Incident Heart Failure. Circulation Heart Failure 2018, 11: e004750. PMID: 29695381, PMCID: PMC5937988, DOI: 10.1161/circheartfailure.117.004750.Peer-Reviewed Original ResearchConceptsHeart failure outcomesExercise capacityCardiac outcomesHeart failureLeft ventricular ejection fractionLeft ventricular filling pressureMeasure of left ventricular filling pressureComposite cardiac outcomeDefinitions of HFpEFExercise hemodynamic measurementsPeak VO<sub>2</sub>Ventricular ejection fractionAdverse cardiac outcomesVentricular filling pressureFailure outcomesCardiopulmonary exercise testingBody mass indexPredicting exercise capacityIncident heart failureDifferentiate HFpEFNon-HFpEFEjection fractionHFpEF diagnosisMm HgFollow-up
2014
Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction
Dhakal B, Malhotra R, Murphy R, Pappagianopoulos P, Baggish A, Weiner R, Houstis N, Eisman A, Hough S, Lewis G. Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction. Circulation Heart Failure 2014, 8: 286-294. PMID: 25344549, PMCID: PMC5771713, DOI: 10.1161/circheartfailure.114.001825.Peer-Reviewed Original ResearchConceptsHeart failureExercise capacityEjection fractionC(a-v)O2Peripheral O2 extractionMechanisms of exercise intoleranceElevated systemic blood pressureIV heart failureReduced ejection fractionCardiac filling pressuresInvasive hemodynamic monitoringMaximum incremental cardiopulmonary exercise testingPeripheral microvascular functionPeak respiratory exchange ratioSystemic blood pressureImpaired exercise capacityO2 extractionPredictors of peak VO2Cardiopulmonary exercise testingIncremental cardiopulmonary exercise testImpairing O2 extractionNYHA IIPeak heart ratePeak oxygen uptakeIntrinsic abnormality