2019
Differential Clinical Profiles, Exercise Responses, and Outcomes Associated With Existing HFpEF Definitions
Ho J, Zern E, Wooster L, Bailey C, Cunningham T, Eisman A, Hardin K, Zampierollo G, Jarolim P, Pappagianopoulos P, Malhotra R, Nayor M, Lewis G. Differential Clinical Profiles, Exercise Responses, and Outcomes Associated With Existing HFpEF Definitions. Circulation 2019, 140: 353-365. PMID: 31132875, PMCID: PMC6684250, DOI: 10.1161/circulationaha.118.039136.Peer-Reviewed Original ResearchConceptsHeart Failure Society of AmericaEuropean Society of CardiologyClinical profileHeart failureCardiovascular outcomesComprehensive cardiopulmonary exercise testingHemodynamic profile of patientsChronic exertional dyspneaDefinitions of HFpEFExercise responseSuspected heart failureAmerican College of Cardiology/American Heart AssociationInvasive hemodynamic monitoringPhenotype of patientsIncidence of cardiovascular outcomesCardiopulmonary exercise testingProfile of patientsClinical trial criteriaSociety of CardiologyPeak oxygen uptakeConsecutive patientsHFpEF subgroupsEjection fractionExertional dyspneaPrognostic implications
2015
Pulmonary vascular response patterns during exercise in interstitial lung disease
Degani-Costa L, Levarge B, Digumarthy S, Eisman A, Harris R, Lewis G. Pulmonary vascular response patterns during exercise in interstitial lung disease. European Respiratory Journal 2015, 46: 738-749. PMID: 25976688, DOI: 10.1183/09031936.00191014.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAnaerobic ThresholdCardiac OutputChi-Square DistributionCohort StudiesExercise TestExercise ToleranceFemaleHumansHypertension, PulmonaryLinear ModelsLogistic ModelsLung Diseases, InterstitialMaleMiddle AgedPredictive Value of TestsPrognosisReference ValuesRespiratory Function TestsRetrospective StudiesRisk AssessmentSex FactorsStroke VolumeVascular ResistanceConceptsInterstitial lung diseasePulmonary vascular dysfunctionPulmonary artery pressureAbnormal pulmonary vascular responseInvasive cardiopulmonary exercise testingInterstitial lung disease patientsPulmonary vascular responsePeak oxygen consumptionPulmonary hypertensionAssociated with lower peak oxygen consumptionLung diseaseVascular responsesAbnormal pulmonary artery pressureMean pulmonary artery pressureLow peak oxygen consumptionMinute ventilation/carbon dioxide productionOvert pulmonary hypertensionPulmonary vascular diseaseVentilation/carbon dioxide productionExercise oxygen desaturationPulmonary function testsCardiopulmonary exercise testingBody mass indexMean PAPOxygen desaturation