2020
Exercise Pulmonary Hypertension Predicts Clinical Outcomes in Patients With Dyspnea on Effort
Ho J, Zern E, Lau E, Wooster L, Bailey C, Cunningham T, Eisman A, Hardin K, Farrell R, Sbarbaro J, Schoenike M, Houstis N, Baggish A, Shah R, Nayor M, Malhotra R, Lewis G. Exercise Pulmonary Hypertension Predicts Clinical Outcomes in Patients With Dyspnea on Effort. Journal Of The American College Of Cardiology 2020, 75: 17-26. PMID: 31918830, PMCID: PMC7043927, DOI: 10.1016/j.jacc.2019.10.048.Peer-Reviewed Original ResearchConceptsExercise pulmonary hypertensionPulmonary artery pressurePulmonary hypertensionAbnormal pulmonary artery pressureCardiac outputChronic exertional dyspneaEvent-free survivalInvasive hemodynamic monitoringPredicting clinical outcomesBurden of PHCV event-free survivalCardiopulmonary exercise testingPredicting adverse eventsTargeted therapeutic interventionsPH subtypesExertional dyspneaPrognostic implicationsClinical outcomesAdverse eventsResting pHResponse to exerciseDeath eventsFollow-upHemodynamic assessmentArterial pressure
2016
Pulmonary Vascular Distensibility Predicts Pulmonary Hypertension Severity, Exercise Capacity, and Survival in Heart Failure
Malhotra R, Dhakal B, Eisman A, Pappagianopoulos P, Dress A, Weiner R, Baggish A, Semigran M, Lewis G. Pulmonary Vascular Distensibility Predicts Pulmonary Hypertension Severity, Exercise Capacity, and Survival in Heart Failure. Circulation Heart Failure 2016, 9: e003011. PMID: 27301469, PMCID: PMC4911900, DOI: 10.1161/circheartfailure.115.003011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntihypertensive AgentsArterial PressureCase-Control StudiesDouble-Blind MethodExercise TestExercise ToleranceFemaleHeart FailureHumansHypertension, PulmonaryKaplan-Meier EstimateLinear ModelsMaleMiddle AgedModels, CardiovascularMultivariate AnalysisPhosphodiesterase 5 InhibitorsPredictive Value of TestsProportional Hazards ModelsProspective StudiesPulmonary ArteryRisk AssessmentRisk FactorsSeverity of Illness IndexSildenafil CitrateStroke VolumeTime FactorsTreatment OutcomeVascular StiffnessVasodilator AgentsVentricular Function, RightConceptsPV distensibilityPulmonary arterial hypertensionReduced ejection fractionHeart failureEjection fractionExercise capacityArterial hypertensionHF patientsRight ventricular ejection fractionPulmonary artery wedge pressureReduced ejection fraction groupPulmonary arterial hypertension groupFirst-pass radionuclide ventriculographyPulmonary vasodilator therapyRV systolic functionVentricular ejection fractionLeft heart failurePulmonary artery pressureEjection fraction groupPulmonary hypertension severityRight ventricular performanceArterial hypertension groupInvasive hemodynamic monitoringWeeks of treatmentPredictors of peak VO2Association of Fitness in Young Adulthood With Survival and Cardiovascular Risk: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Shah R, Murthy V, Colangelo L, Reis J, Venkatesh B, Sharma R, Abbasi S, Goff D, Carr J, Rana J, Terry J, Bouchard C, Sarzynski M, Eisman A, Neilan T, Das S, Jerosch-Herold M, Lewis C, Carnethon M, Lewis G, Lima J. Association of Fitness in Young Adulthood With Survival and Cardiovascular Risk: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. JAMA Internal Medicine 2016, 176: 1-9. PMID: 26618471, PMCID: PMC5292201, DOI: 10.1001/jamainternmed.2015.6309.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAsymptomatic DiseasesCardiovascular DiseasesCoronary Artery DiseaseExercise TestFemaleHeart VentriclesHumansHypertrophy, Left VentricularLongitudinal StudiesMaleMiddle AgedMortalityObesityPhysical FitnessProportional Hazards ModelsProspective StudiesTomography, X-Ray ComputedUltrasonographyUnited StatesVascular CalcificationYoung AdultConceptsCardiorespiratory fitnessIncident cardiovascular diseaseCoronary artery calcificationCardiovascular diseaseEffects of cardiorespiratory fitnessHazard of cardiovascular diseaseCoronary Artery Risk DevelopmentHigher level of fitnessImprove cardiorespiratory fitnessAssociation of fitnessBaseline cardiorespiratory fitnessExercise test durationAssessment of obesityAssociated with lower riskFollow-upLevel of fitnessTreadmill exercise testBaseline study visitCardiovascular disease eventsYoung adultsLeft ventricular massSubclinical cardiovascular diseasePresence of coronary artery calcificationYoung adulthoodAssociated with coronary artery calcification
2015
Native Myocardial T1 as a Biomarker of Cardiac Structure in Non-Ischemic Cardiomyopathy
Shah R, Kato S, Roujol S, Murthy V, Bellm S, Kashem A, Basha T, Jang J, Eisman A, Manning W, Nezafat R. Native Myocardial T1 as a Biomarker of Cardiac Structure in Non-Ischemic Cardiomyopathy. The American Journal Of Cardiology 2015, 117: 282-288. PMID: 26684511, DOI: 10.1016/j.amjcard.2015.10.046.Peer-Reviewed Original ResearchConceptsExtracellular volume fractionNative myocardial T1Nonischemic cardiomyopathyNative T1Myocardial T1Right ventricular ejection fractionMyocardial tissue compositionAtrial volume indexNative T1 timeVentricular ejection fractionDiffuse myocardial fibrosisOvert cardiovascular diseaseAssociations of native T1Myocardial tissue remodelingMyocardial T2Ejection fractionMyocardial fibrosisCardiac structureMultivariable adjustmentMyocardial segmentsLVEFMyocardial structureNon-ischemicVolume indexCardiovascular disease