2020
E-Consult Protocoling to Improve the Quality of Cardiac Stress Tests
Shah N, Eisman A, Winchester D, Morrison A, Qureshi R, Sarkar I, Wu W. E-Consult Protocoling to Improve the Quality of Cardiac Stress Tests. JACC Cardiovascular Imaging 2020, 14: 512-514. PMID: 33011119, PMCID: PMC8045139, DOI: 10.1016/j.jcmg.2020.08.009.Peer-Reviewed Original ResearchExercise Pulmonary Hypertension Predicts Clinical Outcomes in Patients With Dyspnea on Effort
Ho J, Zern E, Lau E, Wooster L, Bailey C, Cunningham T, Eisman A, Hardin K, Farrell R, Sbarbaro J, Schoenike M, Houstis N, Baggish A, Shah R, Nayor M, Malhotra R, Lewis G. Exercise Pulmonary Hypertension Predicts Clinical Outcomes in Patients With Dyspnea on Effort. Journal Of The American College Of Cardiology 2020, 75: 17-26. PMID: 31918830, PMCID: PMC7043927, DOI: 10.1016/j.jacc.2019.10.048.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedDyspneaExercise TestExercise ToleranceFemaleFollow-Up StudiesHumansHypertension, PulmonaryMaleMiddle AgedPredictive Value of TestsProspective StudiesTreatment OutcomeConceptsExercise pulmonary hypertensionPulmonary artery pressurePulmonary hypertensionAbnormal pulmonary artery pressureCardiac outputChronic exertional dyspneaEvent-free survivalInvasive hemodynamic monitoringPredicting clinical outcomesBurden of PHCV event-free survivalCardiopulmonary exercise testingPredicting adverse eventsTargeted therapeutic interventionsPH subtypesExertional dyspneaPrognostic implicationsClinical outcomesAdverse eventsResting pHResponse to exerciseDeath eventsFollow-upHemodynamic assessmentArterial pressure
2017
Exercise Intolerance in Heart Failure With Preserved Ejection Fraction
Houstis N, Eisman A, Pappagianopoulos P, Wooster L, Bailey C, Wagner P, Lewis G. Exercise Intolerance in Heart Failure With Preserved Ejection Fraction. Circulation 2017, 137: 148-161. PMID: 28993402, PMCID: PMC5760316, DOI: 10.1161/circulationaha.117.029058.Peer-Reviewed Original ResearchConceptsCardiopulmonary exercise testingExercise capacityCardiac outputExercise intoleranceHeart failurePathway defectsDiffusing capacityExercise testMechanisms of exercise intolerancePeak VO<sub>2</sub>Patient's cardiac outputSymptoms of HFpEFBody mass indexPatient's exercise capacityEjection fractionHFpEFMass indexInvasive monitoringPatient's defectRelative to controlsBlood gasesMultiple defectsPatientsComorbid defectsDisease heterogeneity
2016
Pulmonary Vascular Distensibility Predicts Pulmonary Hypertension Severity, Exercise Capacity, and Survival in Heart Failure
Malhotra R, Dhakal B, Eisman A, Pappagianopoulos P, Dress A, Weiner R, Baggish A, Semigran M, Lewis G. Pulmonary Vascular Distensibility Predicts Pulmonary Hypertension Severity, Exercise Capacity, and Survival in Heart Failure. Circulation Heart Failure 2016, 9: e003011. PMID: 27301469, PMCID: PMC4911900, DOI: 10.1161/circheartfailure.115.003011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntihypertensive AgentsArterial PressureCase-Control StudiesDouble-Blind MethodExercise TestExercise ToleranceFemaleHeart FailureHumansHypertension, PulmonaryKaplan-Meier EstimateLinear ModelsMaleMiddle AgedModels, CardiovascularMultivariate AnalysisPhosphodiesterase 5 InhibitorsPredictive Value of TestsProportional Hazards ModelsProspective StudiesPulmonary ArteryRisk AssessmentRisk FactorsSeverity of Illness IndexSildenafil CitrateStroke VolumeTime FactorsTreatment OutcomeVascular StiffnessVasodilator AgentsVentricular Function, RightConceptsPV distensibilityPulmonary arterial hypertensionReduced ejection fractionHeart failureEjection fractionExercise capacityArterial hypertensionHF patientsRight ventricular ejection fractionPulmonary artery wedge pressureReduced ejection fraction groupPulmonary arterial hypertension groupFirst-pass radionuclide ventriculographyPulmonary vasodilator therapyRV systolic functionVentricular ejection fractionLeft heart failurePulmonary artery pressureEjection fraction groupPulmonary hypertension severityRight ventricular performanceArterial hypertension groupInvasive hemodynamic monitoringWeeks of treatmentPredictors of peak VO2
2015
Abdominal fat radiodensity, quantity and cardiometabolic risk: The Multi-Ethnic Study of Atherosclerosis
Shah R, Allison M, Lima J, Abbasi S, Eisman A, Lai C, Jerosch-Herold M, Budoff M, Murthy V. Abdominal fat radiodensity, quantity and cardiometabolic risk: The Multi-Ethnic Study of Atherosclerosis. Nutrition Metabolism And Cardiovascular Diseases 2015, 26: 114-122. PMID: 26817938, PMCID: PMC4775418, DOI: 10.1016/j.numecd.2015.12.002.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal FatAdiponectinAdiposityAgedAtherosclerosisBiomarkersC-Reactive ProteinFemaleHumansIncidenceInsulinIntra-Abdominal FatLeptinLinear ModelsLogistic ModelsMaleMetabolic SyndromeMiddle AgedMultivariate AnalysisOdds RatioPredictive Value of TestsPrevalenceProportional Hazards ModelsRisk FactorsSubcutaneous Fat, AbdominalTomography, X-Ray ComputedUnited StatesConceptsCardiometabolic riskAssociated with prevalent MetSCardiovascular disease risk factorsMulti-Ethnic Study of AtherosclerosisMeasures of regional fat distributionAssociated with incident MetSMarkers of cardiometabolic riskIncident metabolic syndromeDisease risk factorsFat radiodensityMetabolic syndromeMulti-Ethnic StudyStudy of AtherosclerosisVisceral fat quantityIncident MetSPrevalent MetSRegional fat distributionComputed tomographyMeasure associationsFat quantityFat distributionRisk factorsCardiometabolic dysfunctionAssociated with quantityIntermuscular fat depotsNative Myocardial T1 as a Biomarker of Cardiac Structure in Non-Ischemic Cardiomyopathy
Shah R, Kato S, Roujol S, Murthy V, Bellm S, Kashem A, Basha T, Jang J, Eisman A, Manning W, Nezafat R. Native Myocardial T1 as a Biomarker of Cardiac Structure in Non-Ischemic Cardiomyopathy. The American Journal Of Cardiology 2015, 117: 282-288. PMID: 26684511, DOI: 10.1016/j.amjcard.2015.10.046.Peer-Reviewed Original ResearchMeSH KeywordsCardiomyopathiesFemaleFollow-Up StudiesHumansMagnetic Resonance Imaging, CineMaleMiddle AgedMyocardiumPredictive Value of TestsProspective StudiesStroke VolumeConceptsExtracellular volume fractionNative myocardial T1Nonischemic cardiomyopathyNative T1Myocardial T1Right ventricular ejection fractionMyocardial tissue compositionAtrial volume indexNative T1 timeVentricular ejection fractionDiffuse myocardial fibrosisOvert cardiovascular diseaseAssociations of native T1Myocardial tissue remodelingMyocardial T2Ejection fractionMyocardial fibrosisCardiac structureMultivariable adjustmentMyocardial segmentsLVEFMyocardial structureNon-ischemicVolume indexCardiovascular diseasePulmonary vascular response patterns during exercise in interstitial lung disease
Degani-Costa L, Levarge B, Digumarthy S, Eisman A, Harris R, Lewis G. Pulmonary vascular response patterns during exercise in interstitial lung disease. European Respiratory Journal 2015, 46: 738-749. PMID: 25976688, DOI: 10.1183/09031936.00191014.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAnaerobic ThresholdCardiac OutputChi-Square DistributionCohort StudiesExercise TestExercise ToleranceFemaleHumansHypertension, PulmonaryLinear ModelsLogistic ModelsLung Diseases, InterstitialMaleMiddle AgedPredictive Value of TestsPrognosisReference ValuesRespiratory Function TestsRetrospective StudiesRisk AssessmentSex FactorsStroke VolumeVascular ResistanceConceptsInterstitial lung diseasePulmonary vascular dysfunctionPulmonary artery pressureAbnormal pulmonary vascular responseInvasive cardiopulmonary exercise testingInterstitial lung disease patientsPulmonary vascular responsePeak oxygen consumptionPulmonary hypertensionAssociated with lower peak oxygen consumptionLung diseaseVascular responsesAbnormal pulmonary artery pressureMean pulmonary artery pressureLow peak oxygen consumptionMinute ventilation/carbon dioxide productionOvert pulmonary hypertensionPulmonary vascular diseaseVentilation/carbon dioxide productionExercise oxygen desaturationPulmonary function testsCardiopulmonary exercise testingBody mass indexMean PAPOxygen desaturation