2020
Exercise Pulmonary Hypertension Predicts Clinical Outcomes in Patients With Dyspnea on Effort
Ho J, Zern E, Lau E, Wooster L, Bailey C, Cunningham T, Eisman A, Hardin K, Farrell R, Sbarbaro J, Schoenike M, Houstis N, Baggish A, Shah R, Nayor M, Malhotra R, Lewis G. Exercise Pulmonary Hypertension Predicts Clinical Outcomes in Patients With Dyspnea on Effort. Journal Of The American College Of Cardiology 2020, 75: 17-26. PMID: 31918830, PMCID: PMC7043927, DOI: 10.1016/j.jacc.2019.10.048.Peer-Reviewed Original ResearchConceptsExercise pulmonary hypertensionPulmonary artery pressurePulmonary hypertensionAbnormal pulmonary artery pressureCardiac outputChronic exertional dyspneaEvent-free survivalInvasive hemodynamic monitoringPredicting clinical outcomesBurden of PHCV event-free survivalCardiopulmonary exercise testingPredicting adverse eventsTargeted therapeutic interventionsPH subtypesExertional dyspneaPrognostic implicationsClinical outcomesAdverse eventsResting pHResponse to exerciseDeath eventsFollow-upHemodynamic assessmentArterial pressure
2016
Pulmonary Vascular Distensibility Predicts Pulmonary Hypertension Severity, Exercise Capacity, and Survival in Heart Failure
Malhotra R, Dhakal B, Eisman A, Pappagianopoulos P, Dress A, Weiner R, Baggish A, Semigran M, Lewis G. Pulmonary Vascular Distensibility Predicts Pulmonary Hypertension Severity, Exercise Capacity, and Survival in Heart Failure. Circulation Heart Failure 2016, 9: e003011. PMID: 27301469, PMCID: PMC4911900, DOI: 10.1161/circheartfailure.115.003011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntihypertensive AgentsArterial PressureCase-Control StudiesDouble-Blind MethodExercise TestExercise ToleranceFemaleHeart FailureHumansHypertension, PulmonaryKaplan-Meier EstimateLinear ModelsMaleMiddle AgedModels, CardiovascularMultivariate AnalysisPhosphodiesterase 5 InhibitorsPredictive Value of TestsProportional Hazards ModelsProspective StudiesPulmonary ArteryRisk AssessmentRisk FactorsSeverity of Illness IndexSildenafil CitrateStroke VolumeTime FactorsTreatment OutcomeVascular StiffnessVasodilator AgentsVentricular Function, RightConceptsPV distensibilityPulmonary arterial hypertensionReduced ejection fractionHeart failureEjection fractionExercise capacityArterial hypertensionHF patientsRight ventricular ejection fractionPulmonary artery wedge pressureReduced ejection fraction groupPulmonary arterial hypertension groupFirst-pass radionuclide ventriculographyPulmonary vasodilator therapyRV systolic functionVentricular ejection fractionLeft heart failurePulmonary artery pressureEjection fraction groupPulmonary hypertension severityRight ventricular performanceArterial hypertension groupInvasive hemodynamic monitoringWeeks of treatmentPredictors of peak VO2
2015
Pulmonary vascular response patterns during exercise in interstitial lung disease
Degani-Costa L, Levarge B, Digumarthy S, Eisman A, Harris R, Lewis G. Pulmonary vascular response patterns during exercise in interstitial lung disease. European Respiratory Journal 2015, 46: 738-749. PMID: 25976688, DOI: 10.1183/09031936.00191014.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAnaerobic ThresholdCardiac OutputChi-Square DistributionCohort StudiesExercise TestExercise ToleranceFemaleHumansHypertension, PulmonaryLinear ModelsLogistic ModelsLung Diseases, InterstitialMaleMiddle AgedPredictive Value of TestsPrognosisReference ValuesRespiratory Function TestsRetrospective StudiesRisk AssessmentSex FactorsStroke VolumeVascular ResistanceConceptsInterstitial lung diseasePulmonary vascular dysfunctionPulmonary artery pressureAbnormal pulmonary vascular responseInvasive cardiopulmonary exercise testingInterstitial lung disease patientsPulmonary vascular responsePeak oxygen consumptionPulmonary hypertensionAssociated with lower peak oxygen consumptionLung diseaseVascular responsesAbnormal pulmonary artery pressureMean pulmonary artery pressureLow peak oxygen consumptionMinute ventilation/carbon dioxide productionOvert pulmonary hypertensionPulmonary vascular diseaseVentilation/carbon dioxide productionExercise oxygen desaturationPulmonary function testsCardiopulmonary exercise testingBody mass indexMean PAPOxygen desaturation