Featured Publications
Pulmonary Capillary Wedge Pressure Patterns During Exercise Predict Exercise Capacity and Incident Heart Failure
Eisman A, Shah R, Dhakal B, Pappagianopoulos P, Wooster L, Bailey C, Cunningham T, Hardin K, Baggish A, Ho J, Malhotra R, Lewis G. Pulmonary Capillary Wedge Pressure Patterns During Exercise Predict Exercise Capacity and Incident Heart Failure. Circulation Heart Failure 2018, 11: e004750. PMID: 29695381, PMCID: PMC5937988, DOI: 10.1161/circheartfailure.117.004750.Peer-Reviewed Original ResearchConceptsHeart failure outcomesExercise capacityCardiac outcomesHeart failureLeft ventricular ejection fractionLeft ventricular filling pressureMeasure of left ventricular filling pressureComposite cardiac outcomeDefinitions of HFpEFExercise hemodynamic measurementsPeak VO<sub>2</sub>Ventricular ejection fractionAdverse cardiac outcomesVentricular filling pressureFailure outcomesCardiopulmonary exercise testingBody mass indexPredicting exercise capacityIncident heart failureDifferentiate HFpEFNon-HFpEFEjection fractionHFpEF diagnosisMm HgFollow-up
2017
Exercise Intolerance in Heart Failure With Preserved Ejection Fraction
Houstis N, Eisman A, Pappagianopoulos P, Wooster L, Bailey C, Wagner P, Lewis G. Exercise Intolerance in Heart Failure With Preserved Ejection Fraction. Circulation 2017, 137: 148-161. PMID: 28993402, PMCID: PMC5760316, DOI: 10.1161/circulationaha.117.029058.Peer-Reviewed Original ResearchConceptsCardiopulmonary exercise testingExercise capacityCardiac outputExercise intoleranceHeart failurePathway defectsDiffusing capacityExercise testMechanisms of exercise intolerancePeak VO<sub>2</sub>Patient's cardiac outputSymptoms of HFpEFBody mass indexPatient's exercise capacityEjection fractionHFpEFMass indexInvasive monitoringPatient's defectRelative to controlsBlood gasesMultiple defectsPatientsComorbid defectsDisease heterogeneity