2018
Impaired right ventricular reserve predicts adverse cardiac outcomes in adults with congenital right heart disease
Yeh D, Schmidt A, Eisman A, Serfas J, Naqvi M, Youniss M, Ryfa A, Khan A, Safi L, Tabtabai S, Bhatt A, Lewis G. Impaired right ventricular reserve predicts adverse cardiac outcomes in adults with congenital right heart disease. Heart 2018, 104: 2044. PMID: 30030334, DOI: 10.1136/heartjnl-2017-312572.Peer-Reviewed Original ResearchConceptsCardiopulmonary exercise testingRV reserveRight ventricleHeart failureNew York Heart Association classPrimary composite clinical outcomeFirst-pass radionuclide ventriculographyPrevalence of heart failureRV ejection fractionRV systolic functionEvent-free survivalMedian follow-upCongenital heart diseaseReserve groupComposite clinical outcomeAdverse cardiac outcomesTertiary care centreRight ventricular reserveAdverse cardiovascular outcomesPredicting adverse cardiovascular outcomesSystolic function assessmentRV dilatationACHD populationPrognostic impactAsymptomatic patients
2016
Pulmonary Vascular Distensibility Predicts Pulmonary Hypertension Severity, Exercise Capacity, and Survival in Heart Failure
Malhotra R, Dhakal B, Eisman A, Pappagianopoulos P, Dress A, Weiner R, Baggish A, Semigran M, Lewis G. Pulmonary Vascular Distensibility Predicts Pulmonary Hypertension Severity, Exercise Capacity, and Survival in Heart Failure. Circulation Heart Failure 2016, 9: e003011. PMID: 27301469, PMCID: PMC4911900, DOI: 10.1161/circheartfailure.115.003011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntihypertensive AgentsArterial PressureCase-Control StudiesDouble-Blind MethodExercise TestExercise ToleranceFemaleHeart FailureHumansHypertension, PulmonaryKaplan-Meier EstimateLinear ModelsMaleMiddle AgedModels, CardiovascularMultivariate AnalysisPhosphodiesterase 5 InhibitorsPredictive Value of TestsProportional Hazards ModelsProspective StudiesPulmonary ArteryRisk AssessmentRisk FactorsSeverity of Illness IndexSildenafil CitrateStroke VolumeTime FactorsTreatment OutcomeVascular StiffnessVasodilator AgentsVentricular Function, RightConceptsPV distensibilityPulmonary arterial hypertensionReduced ejection fractionHeart failureEjection fractionExercise capacityArterial hypertensionHF patientsRight ventricular ejection fractionPulmonary artery wedge pressureReduced ejection fraction groupPulmonary arterial hypertension groupFirst-pass radionuclide ventriculographyPulmonary vasodilator therapyRV systolic functionVentricular ejection fractionLeft heart failurePulmonary artery pressureEjection fraction groupPulmonary hypertension severityRight ventricular performanceArterial hypertension groupInvasive hemodynamic monitoringWeeks of treatmentPredictors of peak VO2