2020
Exercise Pulmonary Hypertension Predicts Clinical Outcomes in Patients With Dyspnea on Effort
Ho J, Zern E, Lau E, Wooster L, Bailey C, Cunningham T, Eisman A, Hardin K, Farrell R, Sbarbaro J, Schoenike M, Houstis N, Baggish A, Shah R, Nayor M, Malhotra R, Lewis G. Exercise Pulmonary Hypertension Predicts Clinical Outcomes in Patients With Dyspnea on Effort. Journal Of The American College Of Cardiology 2020, 75: 17-26. PMID: 31918830, PMCID: PMC7043927, DOI: 10.1016/j.jacc.2019.10.048.Peer-Reviewed Original ResearchConceptsExercise pulmonary hypertensionPulmonary artery pressurePulmonary hypertensionAbnormal pulmonary artery pressureCardiac outputChronic exertional dyspneaEvent-free survivalInvasive hemodynamic monitoringPredicting clinical outcomesBurden of PHCV event-free survivalCardiopulmonary exercise testingPredicting adverse eventsTargeted therapeutic interventionsPH subtypesExertional dyspneaPrognostic implicationsClinical outcomesAdverse eventsResting pHResponse to exerciseDeath eventsFollow-upHemodynamic assessmentArterial pressure
2017
Exercise Intolerance in Heart Failure With Preserved Ejection Fraction
Houstis N, Eisman A, Pappagianopoulos P, Wooster L, Bailey C, Wagner P, Lewis G. Exercise Intolerance in Heart Failure With Preserved Ejection Fraction. Circulation 2017, 137: 148-161. PMID: 28993402, PMCID: PMC5760316, DOI: 10.1161/circulationaha.117.029058.Peer-Reviewed Original ResearchConceptsCardiopulmonary exercise testingExercise capacityCardiac outputExercise intoleranceHeart failurePathway defectsDiffusing capacityExercise testMechanisms of exercise intolerancePeak VO<sub>2</sub>Patient's cardiac outputSymptoms of HFpEFBody mass indexPatient's exercise capacityEjection fractionHFpEFMass indexInvasive monitoringPatient's defectRelative to controlsBlood gasesMultiple defectsPatientsComorbid defectsDisease heterogeneity