Featured Publications
Pulmonary Capillary Wedge Pressure Patterns During Exercise Predict Exercise Capacity and Incident Heart Failure
Eisman A, Shah R, Dhakal B, Pappagianopoulos P, Wooster L, Bailey C, Cunningham T, Hardin K, Baggish A, Ho J, Malhotra R, Lewis G. Pulmonary Capillary Wedge Pressure Patterns During Exercise Predict Exercise Capacity and Incident Heart Failure. Circulation Heart Failure 2018, 11: e004750. PMID: 29695381, PMCID: PMC5937988, DOI: 10.1161/circheartfailure.117.004750.Peer-Reviewed Original ResearchConceptsHeart failure outcomesExercise capacityCardiac outcomesHeart failureLeft ventricular ejection fractionLeft ventricular filling pressureMeasure of left ventricular filling pressureComposite cardiac outcomeDefinitions of HFpEFExercise hemodynamic measurementsPeak VO<sub>2</sub>Ventricular ejection fractionAdverse cardiac outcomesVentricular filling pressureFailure outcomesCardiopulmonary exercise testingBody mass indexPredicting exercise capacityIncident heart failureDifferentiate HFpEFNon-HFpEFEjection fractionHFpEF diagnosisMm HgFollow-up
2017
Exercise Intolerance in Heart Failure With Preserved Ejection Fraction
Houstis N, Eisman A, Pappagianopoulos P, Wooster L, Bailey C, Wagner P, Lewis G. Exercise Intolerance in Heart Failure With Preserved Ejection Fraction. Circulation 2017, 137: 148-161. PMID: 28993402, PMCID: PMC5760316, DOI: 10.1161/circulationaha.117.029058.Peer-Reviewed Original ResearchConceptsCardiopulmonary exercise testingExercise capacityCardiac outputExercise intoleranceHeart failurePathway defectsDiffusing capacityExercise testMechanisms of exercise intolerancePeak VO<sub>2</sub>Patient's cardiac outputSymptoms of HFpEFBody mass indexPatient's exercise capacityEjection fractionHFpEFMass indexInvasive monitoringPatient's defectRelative to controlsBlood gasesMultiple defectsPatientsComorbid defectsDisease heterogeneity
2015
Pulmonary vascular response patterns during exercise in interstitial lung disease
Degani-Costa L, Levarge B, Digumarthy S, Eisman A, Harris R, Lewis G. Pulmonary vascular response patterns during exercise in interstitial lung disease. European Respiratory Journal 2015, 46: 738-749. PMID: 25976688, DOI: 10.1183/09031936.00191014.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAnaerobic ThresholdCardiac OutputChi-Square DistributionCohort StudiesExercise TestExercise ToleranceFemaleHumansHypertension, PulmonaryLinear ModelsLogistic ModelsLung Diseases, InterstitialMaleMiddle AgedPredictive Value of TestsPrognosisReference ValuesRespiratory Function TestsRetrospective StudiesRisk AssessmentSex FactorsStroke VolumeVascular ResistanceConceptsInterstitial lung diseasePulmonary vascular dysfunctionPulmonary artery pressureAbnormal pulmonary vascular responseInvasive cardiopulmonary exercise testingInterstitial lung disease patientsPulmonary vascular responsePeak oxygen consumptionPulmonary hypertensionAssociated with lower peak oxygen consumptionLung diseaseVascular responsesAbnormal pulmonary artery pressureMean pulmonary artery pressureLow peak oxygen consumptionMinute ventilation/carbon dioxide productionOvert pulmonary hypertensionPulmonary vascular diseaseVentilation/carbon dioxide productionExercise oxygen desaturationPulmonary function testsCardiopulmonary exercise testingBody mass indexMean PAPOxygen desaturation