Tassos C. Kyriakides, PhD
Assistant Professor of BiostatisticsDownloadHi-Res Photo
Cards
Appointments
Biostatistics
Primary
Additional Titles
Director, Cooperative Studies Program Coordinating Center (West Haven, CT), Department of Veterans Affairs, VA Cooperative Studies Program
Contact Info
Appointments
Biostatistics
Primary
Additional Titles
Director, Cooperative Studies Program Coordinating Center (West Haven, CT), Department of Veterans Affairs, VA Cooperative Studies Program
Contact Info
Appointments
Biostatistics
Primary
Additional Titles
Director, Cooperative Studies Program Coordinating Center (West Haven, CT), Department of Veterans Affairs, VA Cooperative Studies Program
Contact Info
About
Titles
Assistant Professor of Biostatistics
Positions outside Yale
Director, Cooperative Studies Program Coordinating Center (West Haven, CT), Department of Veterans Affairs, VA Cooperative Studies Program
Biography
Dr. Kyriakides collaborates with clinical researchers on numerous research projects and he provides statistical consulting on numerous research protocols. He has been an abstract mentor for young researchers at the International AIDS Conferences since 2012, leads the VACSPCC internship program and is a statistical reviewer for high-impact medical journals (Lancet Infectious Diseases and the Lancet Gastroenterology & Hepatology).
He is the Director at the Department of Veterans' Affairs Cooperative Studies Program (VACSPCC-West Haven) and has worked, as a Senior Biostatistician, on pivotal clinical trials (The OPTIMA Trial, a multi-national HIV/AIDS treatment clinical trial; a surgical clinical trial (The OVER Trial); and a PTSD clinical trial (The VIP-STAR Trial).
Even though his primary research focus is in the area of infectious diseases with particular emphasis on HIV/AIDS and its treatment, he has an interest in the history of medicine, social determinants of health and the socio-cultural dimension of the benefits of Greek/Mediterranean nutrition. He has recently been certified as an Olive Oil Sommelier by the International Culinary Center and the Olive Oil Education Lab in NY City. He is the co-proponent for the establishment of a Yale institute dedicated to the olive tree, its products and their impact on human and planetary health.
Appointments
Biostatistics
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- PhD
- Yale University (1999)
- MPhil
- Yale University (1996)
- BS
- University of California at Los Angeles (1993)
Research
Overview
- On-going pediatric HIV disclosure clinical trial
- On-going VA PTSD clinical trial
- Analysis of data from a VA multi-national HIV therapy management clinical trial
- Analysis of data from a VA clinical trial in repair strategies for abdominal aortic aneurysm
Medical Subject Headings (MeSH)
Clinical Trials as Topic; Controlled Clinical Trials as Topic; Epidemiologic Methods; Epidemiologic Research Design; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Statistics as Topic; Survival Analysis
ORCID
0000-0001-8913-108X
Research at a Glance
Yale Co-Authors
Frequent collaborators of Tassos C. Kyriakides's published research.
Publications Timeline
A big-picture view of Tassos C. Kyriakides's research output by year.
Research Interests
Research topics Tassos C. Kyriakides is interested in exploring.
James Dziura, MPH, PhD
Gerald Friedland, MD
Kimberly Hieftje, PhD
Robert Heimer, PhD
Geliang Gan, MPH, PhD
Lynn E Fiellin, MD
97Publications
3,432Citations
Multicenter Studies as Topic
Randomized Controlled Trials as Topic
Clinical Trials as Topic
Publications
2024
Utility of the PICOTS framework to assess clinical trial disruptions: monitoring the impact of COVID-19 in the Pain Management Collaboratory
Peduzzi P, Brandt C, Dearth C, Dziura J, Farrokhi S, George S, Kyriakides T, Long C, Mascha E, Patterson C, Rhon D, Kerns R. Utility of the PICOTS framework to assess clinical trial disruptions: monitoring the impact of COVID-19 in the Pain Management Collaboratory. Pain Medicine 2024, 25: s34-s40. PMID: 39514876, PMCID: PMC11548861, DOI: 10.1093/pm/pnae078.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPain Management CollaboratoryPICOTS frameworkIndividual-level randomizationPain management researchPragmatic clinical trialsIntervention fidelityCare deliveryStepped-wedgeSpecialty careClinical partnersCOVID-19 experienceIn-personPain managementOutcome assessmentStudy designCOVID-19Nonpharmacologic approachesImpact of COVID-19PICOTExperimental interventionLead investigatorsTrial designDesign of clinical trialsAffective deliveryPainAdapting to change: experiences and recommendations from the Pain Management Collaboratory on modifying statistical analysis plans
Yu Q, George S, Kyriakides T, Rhon D, Morasco B, Dziura J, Fritz J, Geda M, Peduzzi P, Long C. Adapting to change: experiences and recommendations from the Pain Management Collaboratory on modifying statistical analysis plans. Pain Medicine 2024, 25: s49-s53. PMID: 39514871, PMCID: PMC11548855, DOI: 10.1093/pm/pnae073.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPragmatic clinical trialsPain Management CollaboratoryStatistical analysis planTrial protocolAnalysis planEvaluate nonpharmacological interventionsNonpharmacological interventionsTrial launchStudy designSecondary outcomesTrials RegistryPrimary outcomeStudy armsPrincipal investigatorInstitutional review boardClinical trialsTrial initiationCOVID-19-related issuesBest practicesPainSample sizeReview boardSafety monitoring boardOutcomesTrialsRecommendations for monitoring adherence and fidelity in pragmatic trials based on experience in the Pain Management Collaboratory
Dziura J, Gilstad-Hayden K, Coffman C, Long C, Yu Q, Buta E, Coggeshall S, Geda M, Peduzzi P, Kyriakides T. Recommendations for monitoring adherence and fidelity in pragmatic trials based on experience in the Pain Management Collaboratory. Pain Medicine 2024, 25: s41-s48. PMID: 39514878, PMCID: PMC11548857, DOI: 10.1093/pm/pnae080.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPain Management CollaboratoryPragmatic trialPragmatic Explanatory Continuum Indicator SummaryMonitor adherenceElectronic health recordsFidelity dataIntervention deliveryIntervention fidelityIndicator SummaryHealth recordsTrial interventionProtocol adherenceParticipant engagementStudy teamAdherence dataAdherenceTrial integrityInterventionParticipantsSafety monitoring boardFrequent sourcePainLevel of monitoringTrialsMonitoring boardMonitoring and reporting adverse events in pragmatic clinical trials testing nonpharmacological pain management interventions
Burns A, Young-McCaughan S, Davis A, Vining R, Ali J, Fritz J, Morasco B, Rhon D, Roogow R, Kyriakides T, Kerns R. Monitoring and reporting adverse events in pragmatic clinical trials testing nonpharmacological pain management interventions. Pain Medicine 2024, 25: s64-s67. PMID: 39514880, PMCID: PMC11548853, DOI: 10.1093/pm/pnae081.Peer-Reviewed Original ResearchS487 Modification of the Fecal Immunochemical Test (FIT) Return Envelope Process Improves Lab Acceptance Rate
Dominitz J, Robertson D, Beed A, Boardman K, Del Curto B, Gupta S, Imperiale T, LaCasse A, Larson M, Lieberman D, Shaukat A, Sultan S, Kyriakides T. S487 Modification of the Fecal Immunochemical Test (FIT) Return Envelope Process Improves Lab Acceptance Rate. The American Journal Of Gastroenterology 2024, 119: s340-s341. DOI: 10.14309/01.ajg.0001031316.90089.86.Peer-Reviewed Original ResearchConceptsA randomized controlled trial of efficacy and safety of Fecal Microbiota Transplant for preventing recurrent Clostridioides difficile infection
Drekonja D, Shaukat A, Huang Y, Zhang J, Reinink A, Nugent S, Dominitz J, Davis-Karim A, Gerding D, Kyriakides T. A randomized controlled trial of efficacy and safety of Fecal Microbiota Transplant for preventing recurrent Clostridioides difficile infection. Clinical Infectious Diseases 2024, ciae467. PMID: 39271107, DOI: 10.1093/cid/ciae467.Peer-Reviewed Original ResearchAltmetricConceptsCDI recurrenceClostridioides difficile infectionFecal microbiota transplantationRecurrent Clostridioides difficile infectionAdverse eventsPreventing recurrent Clostridioides difficile infectionOral fecal microbiota transplantationMicrobiota transplantationCause of healthcare-associated infectionsSafety of fecal microbiota transplantationDouble-blind clinical trialTrials of efficacyHealthcare-associated infectionsStatistically significant differenceRandomized controlled trialsClinical recurrenceUnformed stoolsPlacebo armPlacebo capsulesPrimary endpointDifficile infectionRecurrent diarrheaAntibiotic treatmentVeterans Health Administration systemClinical trialsEfficacy and safety of implantable cardioverter-defibrillator implantation in the elderly—The I-70 Study: A randomized clinical trial
Singh S, Wininger M, Raitt M, Adabag S, Moore H, Rottman J, Scrymgeour A, Zhang J, Zheng K, Guarino P, Kyriakides T, Group I, Johnson G, Williams A, Beed A, MacMurdy K, Saavedra P. Efficacy and safety of implantable cardioverter-defibrillator implantation in the elderly—The I-70 Study: A randomized clinical trial. Heart Rhythm O2 2024, 5: 365-373. PMID: 38984364, PMCID: PMC11228113, DOI: 10.1016/j.hroo.2024.04.010.Peer-Reviewed Original ResearchConceptsImplantable cardioverter defibrillatorParticipant follow-upPatient treatment preferencesICD implantationFollow-upTarget sample sizeAll-cause hospitalizationsPrimary prevention ICD implantationMonths of follow-upImplantable cardioverter defibrillator therapySafety of implantable cardioverter defibrillatorsImplantable cardioverter defibrillator implantationOptimal medical therapyRate of sudden deathTreatment preferencesImplantable cardioverter defibrillator shocksSafety of ICD implantationConfidence intervalsStudy protocolMedical therapyParticipantsProlonging lifePatientsSudden deathCardioverter defibrillator
2023
How Healthcare Systems Negatively Impact Environmental Health? The Need for Institutional Commitment to Reduce the Ecological Footprint of Medical Services
Piscitelli P, Karaj S, Miani A, Kyriakides T, Greco E, Colicino E, Bray A, Simón F, Vasiliou V, Baccarelli A. How Healthcare Systems Negatively Impact Environmental Health? The Need for Institutional Commitment to Reduce the Ecological Footprint of Medical Services. Epidemiologia 2023, 4: 521-524. PMID: 38131675, PMCID: PMC10871105, DOI: 10.3390/epidemiologia4040043.Peer-Reviewed Original ResearchCitationsAltmetricScientific evidence supporting the newly developed one-health labeling tool “Med-Index”: an umbrella systematic review on health benefits of mediterranean diet principles and adherence in a planeterranean perspective
Zupo R, Castellana F, Piscitelli P, Crupi P, Desantis A, Greco E, Severino F, Pulimeno M, Guazzini A, Kyriakides T, Vasiliou V, Trichopoulou A, Soldati L, La Vecchia C, De Gaetano G, Donati M, Colao A, Miani A, Corbo F, Clodoveo M. Scientific evidence supporting the newly developed one-health labeling tool “Med-Index”: an umbrella systematic review on health benefits of mediterranean diet principles and adherence in a planeterranean perspective. Journal Of Translational Medicine 2023, 21: 755. PMID: 37885010, PMCID: PMC10601192, DOI: 10.1186/s12967-023-04618-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMediterranean diet principlesSystematic reviewAge-related chronic diseasesUmbrella systematic reviewHealth benefitsScientific evidenceRenal healthResultsA totalClinical trialsLiver healthChronic diseasesEligible reviewsObservational studyMedDiet patternEligible publicationsPremature mortalityHealth outcomesPubMed databaseIndependent investigatorsRCT designNeurological disordersObservational designSignificant associationMedDietHealthy nutritionCervical Cancer Prevention Among Veterans: What Is the Impact of Military Sexual Trauma, PTSD, and Women’s Health Primary Care Providers on Screening and Prevention?
Domenicano I, Combellick J, Warren A, Kyriakides T, Brandt C, Haskell S, Goulet J. Cervical Cancer Prevention Among Veterans: What Is the Impact of Military Sexual Trauma, PTSD, and Women’s Health Primary Care Providers on Screening and Prevention? Military Behavioral Health 2023, 11: 226-235. DOI: 10.1080/21635781.2023.2246884.Peer-Reviewed Original ResearchAltmetricConceptsMental health conditionsWomen veteransMilitary sexual traumaCervical cancerCancer screeningCervical cancer screening ratesHealth conditionsVHA medical centersCancer screening ratesCervical cancer preventionCervical cancer screeningMultivariable logistic regressionPrimary care providersSexual traumaDiagnosis of PTSDPTSD disordersPatient characteristicsScreening ratesOutpatient careCancer preventionMultivariable modelMedical CenterCare providersWomen's healthCurrent study
Academic Achievements & Community Involvement
activity The Lancet Infectious Diseases
Peer Review Groups and Grant Study SectionsReviewerDetails02/01/2012 - Presentactivity Yale Center for Clinical Investigation
CommitteesMemberDetailsPediatric Protocol Review Committee09/01/2012 - Presentactivity Association of Yale Alumni in Public Health
CommitteesBoard MemberDetailsBoard of Association of Yale Alumni in Public Health07/01/2012 - Presentactivity Olive Wellness Institute
Advisory BoardsMemberDetailsOlive Wellness InstituteProvides consultation and expertise to the Australian Olive Wellness Institute that deals with wellness and health related to the olive tree and its products.06/12/2018 - Presentactivity Olympism For Humanity
Professional OrganizationsFaculty MemberDetailsFaculty mentor on activities of the Olympism for Humanity Alliance; an international group that focuses on the use of sports and the Olympic ideals for the promotion of social development programs06/30/2013 - Present
News & Links
News
- February 19, 2024Source: CNN
How to know if the olive oil you’re buying is actually good for you
- January 17, 2024Source: CT Public
Seasoned explores olive oil, plus chef JJ Johnson’s ‘The Simple Art of Rice’
- December 13, 2023
New Web App for COVID-19 Immune Antibody to Help Guide Vaccine Uptake and Timing
- December 05, 2023
Human and planetary health benefits of olive oil focus of fifth annual International Yale Symposium
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