Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsKristopher Kahle, MD, PhD
Assistant Professor AdjunctAbout
Research
Publications
2026
De novo chromatin remodelling variants in sporadic Chiari 1 malformation
Mehta N, Dennis E, Li Q, Davalan W, Mekbib K, Hale A, Fan B, Shofi J, Alper S, Jackson E, Haider S, McGee S, Kahle K. De novo chromatin remodelling variants in sporadic Chiari 1 malformation. Brain 2026, awag282. PMID: 42640505, DOI: 10.1093/brain/awag282.Peer-Reviewed Original ResearchRetraction Note: Functional kinomics establishes a critical node of volume-sensitive cation-Cl– cotransporter regulation in the mammalian brain
Zhang J, Gao G, Begum G, Wang J, Khanna A, Shmukler B, Daubner G, de los Heros P, Davies P, Varghese J, Bhuiyan M, Duan J, Zhang J, Duran D, Alper S, Sun D, Elledge S, Alessi D, Kahle K. Retraction Note: Functional kinomics establishes a critical node of volume-sensitive cation-Cl– cotransporter regulation in the mammalian brain. Scientific Reports 2026, 16: 26660. PMID: 42642456, PMCID: PMC13507065, DOI: 10.1038/s41598-026-66445-w.Peer-Reviewed Original ResearchMechanistic insights into Claudin-14 dysfunction implicated in veins of Galen malformation
Rubina, Jamal S, Xu M, Alyemni S, Fan B, Duy P, Zhao S, Hale A, Kahle K, Moin S, Haider S. Mechanistic insights into Claudin-14 dysfunction implicated in veins of Galen malformation. International Journal Of Biological Macromolecules 2026, 381: 154060. PMID: 42617773, DOI: 10.1016/j.ijbiomac.2026.154060.Peer-Reviewed Original ResearchChiari I Malformation as a Human Disease Model of Cerebellar Cognitive–Affective Dysfunction
Davalan W, Butler W, Schmahmann J, Muñoz W, Mehta N, Paulk A, Kahle K. Chiari I Malformation as a Human Disease Model of Cerebellar Cognitive–Affective Dysfunction. The Cerebellum 2026, 25: 126. PMID: 42599541, DOI: 10.1007/s12311-026-02071-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsLive brain biopsy during CSF shunt surgery for precision diagnostics and multi-omic research
Lukkarinen H, Luikku A, Dougalis A, Pelkonen A, Gomez-Budia M, Abushik P, Novosolova N, Jäntti H, Elomaa A, Kaipainen A, Klimko N, Walle P, Jyrkkänen H, Danner N, Piilonen K, Firtser N, Immonen A, Jääskeläinen J, Paterson R, Kahle K, Eide P, Macosko E, Stevens B, Julkunen V, Solje E, Takalo M, Juopperi S, Kemppainen S, Martiskainen H, Lipponen A, Hiltunen M, Rauramaa T, Malm T, Leinonen V. Live brain biopsy during CSF shunt surgery for precision diagnostics and multi-omic research. Alzheimer's Research & Therapy 2026 DOI: 10.1186/s13195-026-02150-0.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGenetically Guided Pharmacotherapy for Structural Neurovascular Lesions
Hale A, Kahle K. Genetically Guided Pharmacotherapy for Structural Neurovascular Lesions. Neurology Genetics 2026, 12: e200413. PMID: 42453853, PMCID: PMC13366159, DOI: 10.1212/nxg.0000000000200413.Peer-Reviewed Original ResearchNeurocognitive and affective dysfunction in Chiari malformation type I.
Davalan W, Mehta N, Hale A, Li Q, Fan B, Munoz W, Duy P, Butler W, Kahle K. Neurocognitive and affective dysfunction in Chiari malformation type I. Journal Of Neurosurgery Pediatrics 2026, 1-12. PMID: 42430798, DOI: 10.3171/2026.2.peds25432.Peer-Reviewed Original ResearchDevelopmental genetic determinants of the human cerebrospinal fluid–ventricular system
Dennis E, Li Q, McGee S, Mehta N, Mekbib K, Hatada I, Weston M, Shore A, Cullen E, DeSpenza T, Singh A, Kiziltug E, Hale A, Duy P, Fan B, Nelson-Williams C, Moreno-de-Luca A, Kasper E, Smith H, Davalan W, Luikart B, Haider S, Alper S, Lifton R, Jin S, Kahle K. Developmental genetic determinants of the human cerebrospinal fluid–ventricular system. Science Translational Medicine 2026, 18: eaec4386. PMID: 42418557, DOI: 10.1126/scitranslmed.aec4386.Peer-Reviewed Original ResearchTowards precision medicine for brain arteriovenous malformations
Hale A, Kundishora A, Kalailingam P, Barak T, Duy P, Ramundo C, Fan B, Li Q, Brastianos P, Shankar G, Alper S, Kleinstiver B, Musolino P, Kahle K. Towards precision medicine for brain arteriovenous malformations. Journal Of Clinical Investigation 2026, 136: e205086. PMID: 42138076, PMCID: PMC13178655, DOI: 10.1172/jci205086.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsExpanding the scope of pediatric epilepsy surgery: Access, indications, and outcomes in a modern cohort
McLaren J, Muñoz W, Kwon H, Geffrey A, Nanda P, Thibert R, Grossmann L, Stufflebeam S, Jaimes C, Emerton B, Kahle K, Richardson R, Chu C. Expanding the scope of pediatric epilepsy surgery: Access, indications, and outcomes in a modern cohort. Epilepsia Open 2026, 11: 935-948. PMID: 41915477, PMCID: PMC13238926, DOI: 10.1002/epi4.70257.Peer-Reviewed Original Research