2024
The relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives
Arutiunian V, Santhosh M, Neuhaus E, Borland H, Tompkins C, Bernier R, Bookheimer S, Dapretto M, Gupta A, Jack A, Jeste S, McPartland J, Naples A, Van Horn J, Pelphrey K, Webb S. The relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives. Molecular Autism 2024, 15: 19. PMID: 38711098, PMCID: PMC11075235, DOI: 10.1186/s13229-024-00598-1.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderElevated gamma powerLow language skillsGamma powerResponses to speech stimuliLanguage skillsLanguage functionFirst-degree relativesSpectrum disorderClinical Evaluation of Language FundamentalsCo-occurring language impairmentSpeech stimuliCortical gamma-band oscillationsHigh gamma powerSex-balanced sampleGamma-band oscillationsSample of participantsNonverbal IQLanguage impairmentASD participantsTD controlsNeural profilesAutism phenotypeTD groupLanguage FundamentalsConduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder
Newman B, Jacokes Z, Venkadesh S, Webb S, Kleinhans N, McPartland J, Druzgal T, Pelphrey K, Van Horn J, Consortium F. Conduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder. PLOS ONE 2024, 19: e0301964. PMID: 38630783, PMCID: PMC11023574, DOI: 10.1371/journal.pone.0301964.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial Communication QuestionnaireSpectrum disorderCharacteristics of autism spectrum disorderAssociated with higher scoresEtiology of autism spectrum disorderMagnetic resonance imagingNeurotypical participantsWhite matter skeletonCommunication QuestionnaireBehavioral functionsFunctional connectivityT1w/T2w ratioNeuronal differencesStructural connectivityAdolescent participantsHigher scoresConduction velocityCortexExtracellular waterDisordersResonance imagingDiffusion MRI techniques
2023
Frontal EEG alpha asymmetry in youth with autism: Sex differences and social–emotional correlates
Neuhaus E, Santhosh M, Kresse A, Aylward E, Bernier R, Bookheimer S, Jeste S, Jack A, McPartland J, Naples A, Van Horn J, Pelphrey K, Webb S, Network A. Frontal EEG alpha asymmetry in youth with autism: Sex differences and social–emotional correlates. Autism Research 2023, 16: 2364-2377. PMID: 37776030, PMCID: PMC10840952, DOI: 10.1002/aur.3032.Peer-Reviewed Original ResearchConceptsAutistic youthFrontal alpha powerMaternal depression historyIndividual differencesExternalizing behaviorsAlpha powerFrontal EEG alpha asymmetrySocial-emotional correlatesDepression historyEEG alpha asymmetryMental health behaviorsModel of riskAffective styleAutism featuresInternalizing symptomsASD diagnosisAlpha asymmetryAutistic femalesBehavioral indicesLevels of analysisAutistic malesEEG markersGroup differencesParticipant groupsASDThe Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC‐CT) feasibility study
Shic F, Barney E, Naples A, Dommer K, Chang S, Li B, McAllister T, Atyabi A, Wang Q, Bernier R, Dawson G, Dziura J, Faja S, Jeste S, Murias M, Johnson S, Sabatos‐DeVito M, Helleman G, Senturk D, Sugar C, Webb S, McPartland J, Chawarska K, Trials T. The Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC‐CT) feasibility study. Autism Research 2023, 16: 2150-2159. PMID: 37749934, PMCID: PMC11003770, DOI: 10.1002/aur.3026.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial attention taskSchool-aged childrenAttention taskASD groupSpectrum disorderEye-tracking taskTotal T-scoreAttentional patternsAutism spectrumTD groupPresentation timeTrial feasibility studyGroup differencesPercent of timeOlder childrenTaskComparison groupToddlersT-scoreChildrenChildren 4Outcome variablesFaceCondition effectsDevelopment of peak alpha frequency reflects a distinct trajectory of neural maturation in autistic children
Finn C, Han G, Naples A, Wolf J, McPartland J. Development of peak alpha frequency reflects a distinct trajectory of neural maturation in autistic children. Autism Research 2023, 16: 2077-2089. PMID: 37638733, DOI: 10.1002/aur.3017.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAutism Spectrum DisorderAutistic DisorderChildCognitionElectroencephalographyHumansConceptsPeak alpha frequencyAutism spectrum disorderCognitive abilitiesAutistic childrenNonverbal IQNeural maturationSpectrum disorderTypical age-related increaseAlpha frequencyDifferent developmental trajectoriesDistinct trajectoriesSample of childrenCurrent study clarifiesDiagnostic groupsNeurotypical childrenNeurotypical controlsBehavioral measuresDevelopmental trajectoriesDiagnostic statusAge-related increaseFunction of ageIQEffect of ageBivariate relationsPrevious findings
2020
N400 amplitude, latency, and variability reflect temporal integration of beat gesture and pitch accent during language processing
Morett LM, Landi N, Irwin J, McPartland JC. N400 amplitude, latency, and variability reflect temporal integration of beat gesture and pitch accent during language processing. Brain Research 2020, 1747: 147059. PMID: 32818527, PMCID: PMC7493208, DOI: 10.1016/j.brainres.2020.147059.Peer-Reviewed Original ResearchNeural responsivity to social rewards in autistic female youth
Lawrence KE, Hernandez LM, Eilbott J, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, Geschwind DH, McPartland JC, Nelson CA, Webb SJ, Pelphrey KA, Bookheimer SY, Dapretto M. Neural responsivity to social rewards in autistic female youth. Translational Psychiatry 2020, 10: 178. PMID: 32488083, PMCID: PMC7266816, DOI: 10.1038/s41398-020-0824-8.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttentionAutistic DisorderChildFemaleHumansMagnetic Resonance ImagingMaleMotivationRewardConceptsImplicit learning taskSocial rewardsAutistic girlsAutistic boysLearning taskSocial reward processingSocial reward systemFemale youthPrevious neuroimaging studiesFunctional magnetic resonanceLateral frontal cortexSocial stimuliNeural responsivityReward processingSocial motivationRewarding stimuliAnterior insulaGreater activityNeural activationNeuroimaging studiesPotential sex differencesRewarding natureSalience detectionAutistic femalesBehavioral evidenceSex Differences in Functional Connectivity of the Salience, Default Mode, and Central Executive Networks in Youth with ASD
Lawrence KE, Hernandez LM, Bowman HC, Padgaonkar NT, Fuster E, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, Geschwind DH, McPartland JC, Nelson CA, Webb SJ, Pelphrey KA, Green SA, Bookheimer SY, Dapretto M, Consortium G. Sex Differences in Functional Connectivity of the Salience, Default Mode, and Central Executive Networks in Youth with ASD. Cerebral Cortex 2020, 30: 5107-5120. PMID: 32350530, PMCID: PMC7391269, DOI: 10.1093/cercor/bhaa105.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCentral executive networkDefault mode networkFunctional connectivitySalience networkExecutive networkSymptomatology of ASDGreater functional connectivitySex-related biological factorsSample of girlsSN functional connectivitySex differencesAltered functional connectivityASD exhibitNeurotypical individualsNeurocognitive networksTypical developmentNeural mechanismsSpectrum disorderDefault modeMode networkParticipant sexMale samplesYouthGirlsHigher Depressive Symptoms Predict Lower Social Adaptive Functioning in Children and Adolescents with ASD
Duan S, Lee M, Wolf J, Naples AJ, McPartland JC. Higher Depressive Symptoms Predict Lower Social Adaptive Functioning in Children and Adolescents with ASD. Journal Of Clinical Child & Adolescent Psychology 2020, 51: 203-210. PMID: 32347746, DOI: 10.1080/15374416.2020.1750020.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderAdaptive functioningDepressive symptomsHigher depressive symptomsDaily living skillsSocial adaptiveTypical developmentSocial skillsSpectrum disorderLiving skillsSocial domainsLower functioningAdaptive functionAdolescentsFunctioningDepressive symptomatologyChildrenDifferent domainsSkillsIQSymptomsPresent studyYears of ageLight-Adapted Electroretinogram Differences in Autism Spectrum Disorder
Constable PA, Ritvo ER, Ritvo AR, Lee IO, McNair ML, Stahl D, Sowden J, Quinn S, Skuse DH, Thompson DA, McPartland JC. Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2020, 50: 2874-2885. PMID: 32034650, DOI: 10.1007/s10803-020-04396-5.Peer-Reviewed Original Research
2018
Neurophysiological correlates of holistic face processing in adolescents with and without autism spectrum disorder
Naumann S, Senftleben U, Santhosh M, McPartland J, Webb SJ. Neurophysiological correlates of holistic face processing in adolescents with and without autism spectrum disorder. Journal Of Neurodevelopmental Disorders 2018, 10: 27. PMID: 30165814, PMCID: PMC6118009, DOI: 10.1186/s11689-018-9244-y.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderMooney stimuliHolistic processingHolistic faceSpectrum disorderIQ-matched neurotypical controlsFace processing strategiesGamma-band activitySlow response timeMooney imagesFace processingASD engageASD groupERP componentsElectroencephalography (EEG) correlatesNeurophysiological correlatesNeurotypical controlsTemporal processingEarly processingP1 amplitudeNeural systemsProcessing strategiesGamma activityStimuliP1 latencyResting-state alpha power is selectively associated with autistic traits reflecting behavioral rigidity
Carter Leno V, Tomlinson SB, Chang SA, Naples AJ, McPartland JC. Resting-state alpha power is selectively associated with autistic traits reflecting behavioral rigidity. Scientific Reports 2018, 8: 11982. PMID: 30097597, PMCID: PMC6086866, DOI: 10.1038/s41598-018-30445-2.Peer-Reviewed Original ResearchElectrophysiological response during auditory gap detection: Biomarker for sensory and communication alterations in autism spectrum disorder?
Foss-Feig JH, Stavropoulos KKM, McPartland JC, Wallace MT, Stone WL, Key AP. Electrophysiological response during auditory gap detection: Biomarker for sensory and communication alterations in autism spectrum disorder? Developmental Neuropsychology 2018, 43: 109-122. PMID: 29436853, PMCID: PMC5972824, DOI: 10.1080/87565641.2017.1365869.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderAuditory gap detectionSpectrum disorderP2 event-related potential (ERP) componentsEvent-related potential componentGap detectionLanguage-related impairmentsAuditory processing deficitsElectrophysiological responsesProcessing deficitsAuditory stimuliNeural responsesAuditory inputASD biomarkersSilent gapsPotential componentsCommunication alterationsTemporal aspectsDeficitsAmplitude reductionDisordersStimuliSensory symptomsTreatment responseImpairment
2017
Social Media Use, Friendship Quality, and the Moderating Role of Anxiety in Adolescents with Autism Spectrum Disorder
van Schalkwyk GI, Marin CE, Ortiz M, Rolison M, Qayyum Z, McPartland JC, Lebowitz ER, Volkmar FR, Silverman WK. Social Media Use, Friendship Quality, and the Moderating Role of Anxiety in Adolescents with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2017, 47: 2805-2813. PMID: 28616856, PMCID: PMC6688174, DOI: 10.1007/s10803-017-3201-6.Peer-Reviewed Original ResearchConceptsFriendship qualityAnxiety levelsSocial media useHigher friendship qualityComplex social informationAutism spectrum disorderMedia useSpectrum disorderSocial informationModerating RoleSocial mediaSocial engagementASDOffline social activitiesAnxietyAdolescentsSignificant anxietyComparison controlsSocial activities
2015
Common and distinct modulation of electrophysiological indices of feedback processing by autistic and psychopathic traits
Leno V, Naples A, Cox A, Rutherford H, McPartland JC. Common and distinct modulation of electrophysiological indices of feedback processing by autistic and psychopathic traits. Social Neuroscience 2015, 11: 455-466. PMID: 26471250, PMCID: PMC4939614, DOI: 10.1080/17470919.2015.1108223.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderPsychopathic traitsFeedback processingEvent-related potentialsCommon brain mechanismsNonsocial feedbackNeural correlatesAutistic traitsAntisocial domainsBrain mechanismsElectrophysiological indicesSocial feedbackTask performanceBehavioral tasksNeural responsesSpectrum disorderSocial dysfunctionSocial behaviorManipulation domainSimilar difficultiesCurrent studyProcessingDistinct modulationTraitsSpecific form
2014
Varieties of Misdiagnosis in ASD: An Illustrative Case Series
Van Schalkwyk GI, Peluso F, Qayyum Z, McPartland JC, Volkmar FR. Varieties of Misdiagnosis in ASD: An Illustrative Case Series. Journal Of Autism And Developmental Disorders 2014, 45: 911-918. PMID: 25218849, DOI: 10.1007/s10803-014-2239-y.Peer-Reviewed Original Research
2013
Sex Differences in Social Perception in Children with ASD
Coffman MC, Anderson LC, Naples AJ, McPartland JC. Sex Differences in Social Perception in Children with ASD. Journal Of Autism And Developmental Disorders 2013, 45: 589-599. PMID: 24293083, PMCID: PMC4039621, DOI: 10.1007/s10803-013-2006-5.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial information processingFace perceptionEvent Related PotentialsInformation processingSex differencesSocial functionERP markersNeural correlatesASD literatureSocial perceptionFace responsesSpectrum disorderRelated potentialsSocial functioningBrain recordingsObserved sex differencesSymptom severityPerceptionUnderrepresentation of femalesCurrent studyInfluential differencesNeural phenotypesCorrelatesChildren
2012
Brief Report: Comparability of DSM-IV and DSM-5 ASD Research Samples
Mazefsky CA, McPartland JC, Gastgeb HZ, Minshew NJ. Brief Report: Comparability of DSM-IV and DSM-5 ASD Research Samples. Journal Of Autism And Developmental Disorders 2012, 43: 1236-1242. PMID: 23011251, PMCID: PMC3635090, DOI: 10.1007/s10803-012-1665-y.Peer-Reviewed Original ResearchMultimodal emotion processing in autism spectrum disorders: An event-related potential study
Lerner MD, McPartland JC, Morris JP. Multimodal emotion processing in autism spectrum disorders: An event-related potential study. Developmental Cognitive Neuroscience 2012, 3: 11-21. PMID: 23245216, PMCID: PMC6987640, DOI: 10.1016/j.dcn.2012.08.005.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderInformation processing speedEmotion recognition performanceEvent-related potentialsEmotion processingEmotion recognitionProcessing speedSpectrum disorderEvent-related potential studyRecognition performanceMultimodal emotion processingEmotion identification taskVocal emotion recognitionCognitive processesIntact recognitionPerceptual modalitiesAdult facesNeural indicatorsERP componentsEmotion evaluationElectrophysiological markersBehavioral performanceIdentification taskPotential studiesIntervention targetsThe perception and identification of facial emotions in individuals with autism spectrum disorders using the Let’s Face It! Emotion Skills Battery
Tanaka JW, Wolf JM, Klaiman C, Koenig K, Cockburn J, Herlihy L, Brown C, Stahl SS, South M, McPartland JC, Kaiser MD, Schultz RT. The perception and identification of facial emotions in individuals with autism spectrum disorders using the Let’s Face It! Emotion Skills Battery. Journal Of Child Psychology And Psychiatry 2012, 53: 1259-1267. PMID: 22780332, PMCID: PMC3505257, DOI: 10.1111/j.1469-7610.2012.02571.x.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderFacial emotionsTDC participantsPerceptual skillsASD participantsSpectrum disorderEffective social communicationBasic facial emotionsSocial emotional abilitiesDifferent facial identitiesGroups of participantsHolistic encodingAngry expressionsExpression processingFacial identityExpression taskPerceptual strategiesExpressive facesSocial deficitsSocial communicationEmotionsComputer-based assessmentControl participantsHolistic recognitionMouth features