1996
A Double-blind, Placebo-Controlled Study of Fluvoxamine in Adults With Autistic Disorder
McDougle C, Naylor S, Cohen D, Volkmar F, Heninger G, Price L. A Double-blind, Placebo-Controlled Study of Fluvoxamine in Adults With Autistic Disorder. JAMA Psychiatry 1996, 53: 1001-1008. PMID: 8911223, DOI: 10.1001/archpsyc.1996.01830110037005.Peer-Reviewed Original ResearchConceptsStudy of FluvoxamineAutistic disorderSelective serotonin uptake inhibitorAdverse cardiovascular eventsPlacebo-controlled trialWeeks of treatmentSerotonin uptake inhibitorSerotonin neurotransmitter systemShort-term treatmentCardiovascular eventsPlacebo groupMild sedationNeurotransmitter systemsTreatment responseSafe drugUptake inhibitorFluvoxamineSymptoms of autismFluvoxamine maleateDisordersPlaceboAutistic behaviorPatientsAdultsSymptoms
1995
A case-controlled study of repetitive thoughts and behavior in adults with autistic disorder and obsessive-compulsive disorder
McDougle C, Kresch L, Goodman W, Naylor S, Volkmar F, Cohen D, Price L. A case-controlled study of repetitive thoughts and behavior in adults with autistic disorder and obsessive-compulsive disorder. American Journal Of Psychiatry 1995, 152: 772-777. PMID: 7726318, DOI: 10.1176/ajp.152.5.772.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRepetitive thoughtsAutistic disorderAutistic groupSex-matched adultsSymptom ChecklistObsessive-compulsive groupDirect discriminant function analysisYale-Brown Obsessive Compulsive Scale Symptom ChecklistYale-Brown Obsessive Compulsive ScaleObsessive-compulsive symptomsCompulsive Scale Symptom ChecklistObsessive Compulsive ScaleAutistic patientsCase-control studyNeurobiological underpinningsSelf-mutilating behaviorCompulsive ScaleDiscriminant function analysisSomatic contentCounting behaviorConsecutive patientsPrimary diagnosisDisorders ClinicTreatment response