2024
Global deletion of G protein‐coupled receptor 55 impairs glucose homeostasis during obesity by reducing insulin secretion and β‐cell turnover
Liu B, Ruz‐Maldonado I, Persaud S. Global deletion of G protein‐coupled receptor 55 impairs glucose homeostasis during obesity by reducing insulin secretion and β‐cell turnover. Diabetes Obesity And Metabolism 2024, 26: 4591-4601. PMID: 39113250, DOI: 10.1111/dom.15816.Peer-Reviewed Original ResearchGPR55<sup>-/-</sup> miceDiet-induced obesityIncreased islet cell apoptosisHigh-fat dietB cell proliferationWild-typeCytokine-induced apoptosisInsulin secretionCaspase-3/7 activityIslet cell apoptosisGlucose homeostasisInsulin secretion in vivoWT miceB cellsDynamic insulin secretionImpaired glucose-Standard chowSusceptibility to diet-induced obesityPerifusion of isolated isletsIslet functionG protein-coupled receptorsG protein-coupled receptor 55Weeks of dietary interventionReduced insulin secretionB cell turnover
2023
Kisspeptin upregulates β-cell serotonin production during pregnancy
Hill T, Smith L, Ruz-Maldonado I, Jones P, Bowe J. Kisspeptin upregulates β-cell serotonin production during pregnancy. Journal Of Endocrinology 2023, 260: e230218. PMID: 37997938, PMCID: PMC10762540, DOI: 10.1530/joe-23-0218.Peer-Reviewed Original ResearchConceptsIslet adaptationSerotonin productionSerotonin biosynthesisΒ-cellsDevelopment of GDMEffects of kisspeptinLactogenic hormonesGestational insulin resistanceΒ-cell compensationElevated insulin secretionMaternal pancreatic isletsΒ-cell proliferationPregnant controlsInsulin resistanceSerotonin levelsInsulin secretionAutocrine effectsPregnancyTPH-1KisspeptinKnockdown micePancreatic isletsRodent isletsPro-proliferative genesTime points