2018
Amygdala hyper-connectivity in a mouse model of unpredictable early life stress
Johnson FK, Delpech JC, Thompson GJ, Wei L, Hao J, Herman P, Hyder F, Kaffman A. Amygdala hyper-connectivity in a mouse model of unpredictable early life stress. Translational Psychiatry 2018, 8: 49. PMID: 29463821, PMCID: PMC5820270, DOI: 10.1038/s41398-018-0092-z.Peer-Reviewed Original ResearchConceptsEarly life stressAdult male miceAnxiety-like behaviorLimited beddingMale miceMouse modelUnpredictable early life stressAmygdala-prefrontal cortex connectivityChildhood maltreatmentOpen field testFrontolimbic brain regionsResting-state fMRIFrontolimbic connectivityPostnatal stressCortex connectivityAbnormal connectivityAmygdala connectivityAdult miceAnimal modelsFrontolimbic circuitsBrain regionsStress paradigmPrefrontal cortexRobust increaseMice
2016
Early life stress perturbs the maturation of microglia in the developing hippocampus
Delpech JC, Wei L, Hao J, Yu X, Madore C, Butovsky O, Kaffman A. Early life stress perturbs the maturation of microglia in the developing hippocampus. Brain Behavior And Immunity 2016, 57: 79-93. PMID: 27301858, PMCID: PMC5010940, DOI: 10.1016/j.bbi.2016.06.006.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsHippocampusMaternal DeprivationMiceMice, Inbred BALB CMicrogliaStress, PsychologicalConceptsEarly life stressHippocampal developmentLife stressPhagocytic activityAbnormal hippocampal developmentNormal hippocampal developmentMorphology of microgliaPostnatal day 28Vivo phagocytic activityImpairs hippocampal functionMaturation of microgliaImmune panelHippocampal microgliaMicroglial activityMicroglial functionNormal cell numbersSynaptic maturationOld miceMicrogliaMouse modelRodent modelsSynaptic pruningDay 28Old pupsHippocampus