Publications

• Transient impairment in microglial function causes sex-specific deficits in synaptic maturity and hippocampal function in mice exposed to early adversity.Ahmed S, Polis B, Jamwal S, Sanganahalli BG, MacDowell Kaswan Z, Islam R, Kim D, Bowers C, Giuliano L, Biederer T, Hyder F, Kaffman A. Brain Behav Immun. 2024 Nov; 2024 Aug 10. PMID: 39134183.
• Postnatal Enrichment Corrects Deficits in Perineuronal Net Formation and Reversal Learning in Adult Mice Exposed to Early Adversity.Jamwal S, Islam R, Kaswan ZM, Ahmed S, Bowers C, Giuliano L, Kaffman A. bioRxiv. 2024 Sep 23; 2024 Sep 23. PMID: 39386482.
• Microglia: The Drunken Gardeners of Early Adversity.Ahmed S, Polis B, Kaffman A. Biomolecules. 2024 Aug 8; 2024 Aug 8. PMID: 39199352.
• Early adversity causes sex-specific deficits in perforant pathway connectivity and contextual memory in adolescent mice.Islam R, White JD, Arefin TM, Mehta S, Liu X, Polis B, Giuliano L, Ahmed S, Bowers C, Zhang J, Kaffman A. Biol Sex Differ. 2024 May 7; 2024 May 7. PMID: 38715106.
• Transient Impairment in Microglial Function Causes Sex-Specific Deficits in Synaptic and Hippocampal Function in Mice Exposed to Early Adversity.Ahmed S, Polis B, Jamwal S, Sanganahalli BG, Kaswan ZM, Islam R, Kim D, Bowers C, Giuliano L, Biederer T, Hyder F, Kaffman A. bioRxiv. 2024 Feb 15; 2024 Feb 15. PMID: 38405887.
• Early adversity changes the economic conditions of mouse structural brain network organization.Carozza S, Holmes J, Vértes PE, Bullmore E, Arefin TM, Pugliese A, Zhang J, Kaffman A, Akarca D, Astle DE. Dev Psychobiol. 2023 Sep. PMID: 37607894.
• Early life stress impairs synaptic pruning in the developing hippocampus.Dayananda KK, Ahmed S, Wang D, Polis B, Islam R, Kaffman A. Brain Behav Immun. 2023 Jan; 2022 Sep 26. PMID: 36174883.
• Macroscopic Structural and Connectome Mapping of the Mouse Brain Using Diffusion Magnetic Resonance Imaging.Arefin TM, Lee CH, White JD, Zhang J, Kaffman A. Bio Protoc. 2021 Nov 20; 2021 Nov 20. PMID: 34909442.
• Editorial: Effects of Early Life Stress on Neurodevelopment and Health: Bridging the Gap Between Human Clinical Studies and Animal Models.Kaffman A, Herringa RJ, Sanchez MM. Front Hum Neurosci. 2021; 2021 Oct 5. PMID: 34675791.
• Deficits in hippocampal-dependent memory across different rodent models of early life stress: systematic review and meta-analysis.Rocha M, Wang D, Avila-Quintero V, Bloch MH, Kaffman A. Transl Psychiatry. 2021 Apr 20; 2021 Apr 20. PMID: 33879774.
• White-Matter Repair as a Novel Therapeutic Target for Early Adversity.Islam R, Kaffman A. Front Neurosci. 2021; 2021 Apr 9. PMID: 33897364.
• The Promise of Automated Home-Cage Monitoring in Improving Translational Utility of Psychiatric Research in Rodents.Mingrone A, Kaffman A, Kaffman A. Front Neurosci. 2020; 2020 Dec 17. PMID: 33390898.
• Early life stress causes sex-specific changes in adult fronto-limbic connectivity that differentially drive learning.White JD, Arefin TM, Pugliese A, Lee CH, Gassen J, Zhang J, Kaffman A. Elife. 2020 Dec 1; 2020 Dec 1. PMID: 33259286.
• Systematic review and meta-analysis: effects of maternal separation on anxiety-like behavior in rodents.Wang D, Levine JLS, Avila-Quintero V, Bloch M, Kaffman A. Transl Psychiatry. 2020 Jun 1; 2020 Jun 1. PMID: 32483128.
• Editorial Perspective: Childhood maltreatment - the problematic unisex assumption.White JD, Kaffman A. J Child Psychol Psychiatry. 2020 Jun; 2019 Dec 11. PMID: 31828779.
• The Moderating Effects of Sex on Consequences of Childhood Maltreatment: From Clinical Studies to Animal Models.White JD, Kaffman A. Front Neurosci. 2019; 2019 Oct 10. PMID: 31680821.
• Enhancing the Utility of Preclinical Research in Neuropsychiatry Drug Development.Kaffman A, White JD, Wei L, Johnson FK, Krystal JH. Methods Mol Biol. 2019. PMID: 31273690.
• Early life stress perturbs the function of microglia in the developing rodent brain: New insights and future challenges.Johnson FK, Kaffman A. Brain Behav Immun. 2018 Mar; 2017 Jun 15. PMID: 28625767.
• Amygdala hyper-connectivity in a mouse model of unpredictable early life stress.Johnson FK, Delpech JC, Thompson GJ, Wei L, Hao J, Herman P, Hyder F, Kaffman A. Transl Psychiatry. 2018 Feb 21; 2018 Feb 21. PMID: 29463821.
• Early life stress perturbs the maturation of microglia in the developing hippocampus.Delpech JC, Wei L, Hao J, Yu X, Madore C, Butovsky O, Kaffman A. Brain Behav Immun. 2016 Oct; 2016 Jun 11. PMID: 27301858.
• Early-life stress restricts the capacity of adult progenitor cells to differentiate into neurons.Kaffman A. Biol Psychiatry. 2015 Feb 15. PMID: 25592267.
• Early-Life Stress Perturbs Key Cellular Programs in the Developing Mouse Hippocampus.Wei L, Hao J, Lacher RK, Abbott T, Chung L, Colangelo CM, Kaffman A. Dev Neurosci. 2015; 2015 Jun 11. PMID: 26068561.
• Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders.Coplan JD, Fulton SL, Reiner W, Jackowski A, Panthangi V, Perera TD, Gorman JM, Huang YY, Tang CY, Hof PR, Kaffman A, Dwork AJ, Mathew SJ, Kaufman J, Mann JJ. Front Behav Neurosci. 2014; 2014 Dec 23. PMID: 25566007.
• Early life stress inhibits expression of ribosomal RNA in the developing hippocampus.Wei L, Hao J, Kaffman A. PLoS One. 2014; 2014 Dec 17. PMID: 25517398.
• Early life stress and macaque amygdala hypertrophy: preliminary evidence for a role for the serotonin transporter gene.Coplan JD, Fathy HM, Jackowski AP, Tang CY, Perera TD, Mathew SJ, Martinez J, Abdallah CG, Dwork AJ, Pantol G, Carpenter D, Gorman JM, Nemeroff CB, Owens MJ, Kaffman A, Kaufman J. Front Behav Neurosci. 2014; 2014 Oct 6. PMID: 25339875.
• New frontiers in animal research of psychiatric illness.Kaffman A, Krystal JH. Methods Mol Biol. 2012. PMID: 22231804.
• Early life stress inhibits expression of a novel innate immune pathway in the developing hippocampus.Wei L, Simen A, Mane S, Kaffman A. Neuropsychopharmacology. 2012 Jan; 2011 Oct 12. PMID: 21993208.
• Affiliative behavior requires juvenile, but not adult neurogenesis.Wei L, Meaney MJ, Duman RS, Kaffman A. J Neurosci. 2011 Oct 5. PMID: 21976519.
• Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates.Jackowski A, Perera TD, Abdallah CG, Garrido G, Tang CY, Martinez J, Mathew SJ, Gorman JM, Rosenblum LA, Smith EL, Dwork AJ, Shungu DC, Kaffman A, Gelernter J, Coplan JD, Kaufman J. Psychiatry Res. 2011 Apr 30; 2011 Mar 5. PMID: 21377844.
• Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: a pilot study.Coplan JD, Abdallah CG, Kaufman J, Gelernter J, Smith EL, Perera TD, Dwork AJ, Kaffman A, Gorman JM, Rosenblum LA, Owens MJ, Nemeroff CB. Psychoneuroendocrinology. 2011 Feb; 2010 Aug 6. PMID: 20692103.
• The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates.Coplan JD, Abdallah CG, Tang CY, Mathew SJ, Martinez J, Hof PR, Smith EL, Dwork AJ, Perera TD, Pantol G, Carpenter D, Rosenblum LA, Shungu DC, Gelernter J, Kaffman A, Jackowski A, Kaufman J, Gorman JM. Neurosci Lett. 2010 Aug 16; 2010 Jun 10. PMID: 20541590.
• Early life stress increases anxiety-like behavior in Balb c mice despite a compensatory increase in levels of postnatal maternal care.Wei L, David A, Duman RS, Anisman H, Kaffman A. Horm Behav. 2010 Apr; 2010 Jan 22. PMID: 20096699.
• Arguable assumptions, debatable conclusions.Kaufman J, Gelernter J, Kaffman A, Caspi A, Moffitt T. Biol Psychiatry. 2010 Feb 15; 2009 Dec 14. PMID: 20006323.
• The silent epidemic of neurodevelopmental injuries.Kaffman A. Biol Psychiatry. 2009 Oct 1. PMID: 19747590.
• Neurodevelopmental sequelae of postnatal maternal care in rodents: clinical and research implications of molecular insights.Kaffman A, Meaney MJ. J Child Psychol Psychiatry. 2007 Mar-Apr. PMID: 17355397.
• Regulation of nuclear localization: a key to a door.Kaffman A, O'Shea EK. Annu Rev Cell Dev Biol. 1999. PMID: 10611964.
• The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus.Kaffman A, Rank NM, O'Neill EM, Huang LS, O'Shea EK. Nature. 1998 Dec 3. PMID: 9853758.
• Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121.Kaffman A, Rank NM, O'Shea EK. Genes Dev. 1998 Sep 1. PMID: 9732266.
• Regulation of PHO4 nuclear localization by the PHO80-PHO85 cyclin-CDK complex.O'Neill EM, Kaffman A, Jolly ER, O'Shea EK. Science. 1996 Jan 12. PMID: 8539622.
• Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85.Kaffman A, Herskowitz I, Tjian R, O'Shea EK. Science. 1994 Feb 25. PMID: 8108735.