In vitro study
- Cell phenotype/biology
- Gene function
- Signaling/mechanism
Dr. Zhou has focused on translational research from the very beginning of her postgraduate study. To discover the molecular mechanisms and facilitate new therapeutic strategies for vascular diseases, Dr. Zhou has worked on angiogenesis and lymphangiogenesis, predominantly to investigate the role of CCM3, Trx2, SENP1 and AIP1 genes in animal models and in vitro for vascular biology, cell biology and signaling, as well as potential therapeutic targets which would provide promising treatment for vascular diseases such as cerebral cavernous malformation, diabetic retinopathy and cardiomyopathy.
We are open to highly motivated postgraduate students and postgraduates including visiting scholars who has MD degree, PhD degree/candidate, both MD and PhD degree/candidate, to work on exciting on-going directions, especially vascular biology and malformations, vascular diseases (CCM, AVM, Eye diseases and Lymphatic diseases) and translational perspectives. We prefer someone who is experienced in both in vivo and in vitro study. Please contact Dr. Zhou directly with your updated CV if you are interested.
In previous research, Dr. Zhou has:
This lab will continue to investigate the cardiovascular and retinal disease in the aspects of endothelial signaling and biology, vascular malformation and remodeling. The lab is conducting translational research in vascular biology with a focus on human vascular diseases like cerebral cavernous malformations (CCMs) and retinopathy. Our goal is to dissect the signaling pathways in endothelial cells involved in vascular development, remodeling and disease progression. We will use mouse genetic models, in vitro biochemical and cell biological approaches to define the critical molecules mediating vascular development and pathogenesis, to verify the signaling in human disease samples, and to identify therapeutic targets for human vascular diseases.