Nasal Vaccination May Protect Against Respiratory Viruses Better Than Injected Vaccines
Akiko Iwasaki, PhD, discusses her lab's finding that intranasal vaccinations, by triggering immune properties of mucosal membranes, may offer better protection against respiratory viruses than injected vaccines.
Nasal Vaccine May Aid Fight Against New Viral Variants
Akiko Iwasaki and her colleagues found that intranasal vaccination provided broad-based protection against heterologous respiratory viruses in mice, while so-called systemic immunization, which uses an injection to elicit body-wide protection, did not.Source: YaleNews
Sex-specific Immune Response in COVID-19 Linked to Cellular Metabolism
Researchers studying COVID-19 patients have found a metabolic pathway that is highly correlated with immune responses only in male patients, a group known to be more likely to suffer severe cases and die of the disease, representing a potential target for therapeutic intervention.Source: Yale News
Scientists Unravel Mystery of Sex Disparities in COVID-19 Outcomes
"Age and sex are where immunological changes intersect,” says Akiko Iwasaki, PhD. Over the past year, Iwasaki and her colleagues from around the globe have compiled a rich literature of research that reveals in detail these and other factors that make the virus more lethal for men.Source: YaleNews
Understanding Immune System Blunders in Response to the Coronavirus
Genetics, gender, and even botched timing on the part of the immune response all appear important in the development of COVID-19. Akiko Iwasaki, PhD, is leading research to help us better predict who is likely to sail through a bout with COVID-19 and who may need targeted lifesaving care.
Iwasaki Is Honored by the International Cytokine & Interferon Society
Akiko Iwasaki, PhD, Waldemar Von Zedtwitz Profesor of Immunobiology and Molecular, Cellular, and Developmental Biology; and professor of dermatology, is a 2019 recipient of the Seymour & Vivian Milstein Award for Excellence in Interferon and Cytokine Research, given by the International Cytokine & Interferon Society (ICIS).
Study: Topical antibiotic triggers unexpected antiviral response
A Yale-led research team made a startling discovery while investigating the effect of bacteria on viral infections. When they applied a common topical antibiotic to mice before or shortly after infection with herpes and other viruses, they found that the antibiotic triggered an antiviral resistance in the animals, the researchers said.
Aging impairs innate immune response to flu
Aging impairs the immune system’s response to the flu virus in multiple ways, weakening resistance in older adults, according to a Yale study. The research reveals why older people are at increased risk of illness and death from flu, the researchers said.
Yale Scientist Serves As Mentor, Launches HPV Vaccine Campaign
Growing up in a small town in southern New Mexico, Kellie Jurado had never met a scientist or considered a career in science until she got to college. That’s part of why Jurado, now a Harvard-educated post-doctoral scientist at Yale and the recent winner of a $60,000 fellowship, is so committed to helping others from minority and disadvantaged communities learn about science and get excited by it.Source: Hartford Courant
Research note: The immune system-body weight connection
A new Yale study, led by professor of immunobiology and Howard Hughes Medical Institute investigator Akiko Iwasaki, identified a population of macrophages, a type of white blood cell, that resides within the fat tissue to maintain body weight.
Constipated? Study finds surprising cause
A Yale-led study has shown a surprising link between constipation and herpes infection. The finding, published June 8 in Cell Host & Microbe, advances the science on herpes, and could help patients with chronic gastrointestinal diseases with no clear cause.
Yale study: How antibodies access neurons to fight infection
Yale scientists have solved a puzzle of the immune system: how antibodies enter the nervous system to control viral infections. Their finding may have implications for the prevention and treatment of a range of conditions, including herpes and Guillain-Barre syndrome, which has been linked to the Zika virus.
Yale study suggests that immune response to flu causes death in older people, not the virus
A new Yale-led study suggests that death from influenza virus in older people may be primarily caused by a damaging immune response to flu and not by the virus itself. The insight could lead to novel strategies for combating flu in the most vulnerable patients, said the researchers.