Publications

2020

SARS-CoV-2 infection of the placenta.Hosier H, Farhadian SF, Morotti RA, Deshmukh U, Lu-Culligan A, Campbell KH, Yasumoto Y, Vogels CB, Casanovas-Massana A, Vijayakumar P, Geng B, Odio CD, Fournier J, Brito AF, Fauver JR, Liu F, Alpert T, Tal R, Szigeti-Buck K, Perincheri S, Larsen CP, Gariepy AM, Aguilar G, Fardelmann KL, Harigopal M, Taylor HS, Pettker CM, Wyllie AL, Dela Cruz CS, Ring AM, Grubaugh ND, Ko AI, Horvath TL, Iwasaki A, Reddy UM, Lipkind HS. J Clin Invest. 2020 Jun 23; 2020 Jun 23. PMID: 32573498.
Vitamin B12 and folic acid alleviate symptoms of nutritional deficiency by antagonizing aryl hydrocarbon receptor.Kim DJ, Venkataraman A, Jain PC, Wiesler EP, DeBlasio M, Klein J, Tu SS, Lee S, Medzhitov R, Iwasaki A. Proc Natl Acad Sci U S A. 2020 Jun 22; 2020 Jun 22. PMID: 32571957.
m⁶A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development.Gao Y, Vasic R, Song Y, Teng R, Liu C, Gbyli R, Biancon G, Nelakanti R, Lobben K, Kudo E, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, Lee V, Dura B, Viero G, Iwasaki A, Fan R, Xiao A, Flavell RA, Li HB, Tebaldi T, Halene S. Immunity. 2020 Jun 16; 2020 Jun 3. PMID: 32497523.
Type I and Type III Interferons - Induction, Signaling, Evasion, and Application to Combat COVID-19.Park A, Iwasaki A. Cell Host Microbe. 2020 Jun 10; 2020 May 27. PMID: 32464097.
Sex differences in immune responses to SARS-CoV-2 that underlie disease outcomes.Takahashi T, Wong P, Ellingson M, Lucas C, Klein J, Israelow B, Silva J, Oh J, Mao T, Tokuyama M, Lu P, Venkataraman A, Park A, Liu F, Meir A, Sun J, Wang E, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott I, Moore A, Casanovas A, Dela Cruz C, Fournier J, Odio C, Farhadian S, Grubaugh N, Schultz W, Ko A, Ring A, Omer S, Iwasaki A. medRxiv. 2020 Jun 9; 2020 Jun 9. PMID: 32577695.
Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19.Yap JKY, Moriyama M, Iwasaki A. J Immunol. 2020 Jun 3; 2020 Jun 3. PMID: 32493814.
The potential danger of suboptimal antibody responses in COVID-19.Iwasaki A, Yang Y. Nat Rev Immunol. 2020 Jun. PMID: 32317716.
Coast-to-Coast Spread of SARS-CoV-2 during the Early Epidemic in the United States.Fauver JR, Petrone ME, Hodcroft EB, Shioda K, Ehrlich HY, Watts AG, Vogels CBF, Brito AF, Alpert T, Muyombwe A, Razeq J, Downing R, Cheemarla NR, Wyllie AL, Kalinich CC, Ott IM, Quick J, Loman NJ, Neugebauer KM, Greninger AL, Jerome KR, Roychoudhury P, Xie H, Shrestha L, Huang ML, Pitzer VE, Iwasaki A, Omer SB, Khan K, Bogoch II, Martinello RA, Foxman EF, Landry ML, Neher RA, Ko AI, Grubaugh ND. Cell. 2020 May 28; 2020 May 7. PMID: 32386545.
Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling.Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. bioRxiv. 2020 May 27; 2020 May 27. PMID: 32577647.
Why does Japan have so few cases of COVID-19?Iwasaki A, Grubaugh ND. EMBO Mol Med. 2020 May 8; 2020 Apr 28. PMID: 32275804.
Contributions of maternal and fetal antiviral immunity in congenital disease.Yockey LJ, Lucas C, Iwasaki A. Science. 2020 May 8. PMID: 32381717.
Single-cell longitudinal analysis of SARS-CoV-2 infection in human bronchial epithelial cells.Ravindra NG, Alfajaro MM, Gasque V, Wei J, Filler RB, Huston NC, Wan H, Szigeti-Buck K, Wang B, Montgomery RR, Eisenbarth SC, Williams A, Pyle AM, Iwasaki A, Horvath TL, Foxman EF, van Dijk D, Wilen CB. bioRxiv. 2020 May 7; 2020 May 7. PMID: 32511382.
Cutting Edge: The Use of Topical Aminoglycosides as an Effective Pull in "Prime and Pull" Vaccine Strategy.Gopinath S, Lu P, Iwasaki A. J Immunol. 2020 Apr 1; 2020 Mar 2. PMID: 32122994.
Antidote to toxic principal investigators.Iwasaki A. Nat Med. 2020 Apr. PMID: 32273601.
Coast-to-coast spread of SARS-CoV-2 in the United States revealed by genomic epidemiology.Fauver JR, Petrone ME, Hodcroft EB, Shioda K, Ehrlich HY, Watts AG, Vogels CBF, Brito AF, Alpert T, Muyombwe A, Razeq J, Downing R, Cheemarla NR, Wyllie AL, Kalinich CC, Ott I, Quick J, Loman NJ, Neugebauer KM, Greninger AL, Jerome KR, Roychoundhury P, Xie H, Shrestha L, Huang ML, Pitzer VE, Iwasaki A, Omer SB, Khan K, Bogoch I, Martinello RA, Foxman EF, Landry ML, Neher RA, Ko AI, Grubaugh ND. medRxiv. 2020 Mar 26; 2020 Mar 26. PMID: 32511630.
Seasonality of Respiratory Viral Infections.Moriyama M, Hugentobler WJ, Iwasaki A. Annu Rev Virol. 2020 Mar 20; 2020 Mar 20. PMID: 32196426.
VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours.Song E, Mao T, Dong H, Boisserand LSB, Antila S, Bosenberg M, Alitalo K, Thomas JL, Iwasaki A. Nature. 2020 Jan; 2020 Jan 15. PMID: 31942068.

2019

RIG-I Recognition of RNA Targets: The Influence of Terminal Base Pair Sequence and Overhangs on Affinity and Signaling.Ren X, Linehan MM, Iwasaki A, Pyle AM. Cell Rep. 2019 Dec 17. PMID: 31851914.
Universal Principled Review: A Community-Driven Method to Improve Peer Review.Krummel M, Blish C, Kuhns M, Cadwell K, Oberst A, Goldrath A, Ansel KM, Chi H, O'Connell R, Wherry EJ, Pepper M. Cell. 2019 Dec 12. PMID: 31835023.
Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses.Jiang X, Muthusamy V, Fedorova O, Kong Y, Kim DJ, Bosenberg M, Pyle AM, Iwasaki A. J Exp Med. 2019 Dec 2; 2019 Oct 10. PMID: 31601678.
Ketogenic diet activates protective γδ T cell responses against influenza virus infection.Goldberg EL, Molony RD, Kudo E, Sidorov S, Kong Y, Dixit VD, Iwasaki A. Sci Immunol. 2019 Nov 15. PMID: 31732517.
Murine Leukemia Virus Exploits Innate Sensing by Toll-Like Receptor 7 in B-1 Cells To Establish Infection and Locally Spread in Mice.Pi R, Iwasaki A, Sewald X, Mothes W, Uchil PD. J Virol. 2019 Nov 1; 2019 Oct 15. PMID: 31434732.
Human APOBEC3G Prevents Emergence of Infectious Endogenous Retrovirus in Mice.Treger RS, Tokuyama M, Dong H, Salas-Briceno K, Ross SR, Kong Y, Iwasaki A. J Virol. 2019 Oct 15; 2019 Sep 30. PMID: 31341050.
Why we need to increase diversity in the immunology research community.Iwasaki A. Nat Immunol. 2019 Sep. PMID: 31427777.
Effector T_H17 Cells Give Rise to Long-Lived T_RM Cells that Are Essential for an Immediate Response against Bacterial Infection.Amezcua Vesely MC, Pallis P, Bielecki P, Low JS, Zhao J, Harman CCD, Kroehling L, Jackson R, Bailis W, Licona-Limón P, Xu H, Iijima N, Pillai PS, Kaplan DH, Weaver CT, Kluger Y, Kowalczyk MS, Iwasaki A, Pereira JP, Esplugues E, Gagliani N, Flavell RA. Cell. 2019 Aug 22. PMID: 31442406.
Successful application of prime and pull strategy for a therapeutic HSV vaccine.Bernstein DI, Cardin RD, Bravo FJ, Awasthi S, Lu P, Pullum DA, Dixon DA, Iwasaki A, Friedman HM. NPJ Vaccines. 2019; 2019 Aug 1. PMID: 31396405.
Migrant memory B cells secrete luminal antibody in the vagina.Oh JE, Iijima N, Song E, Lu P, Klein J, Jiang R, Kleinstein SH, Iwasaki A. Nature. 2019 Jul; 2019 Jun 12. PMID: 31189952.
The Combination of MEK Inhibitor With Immunomodulatory Antibodies Targeting Programmed Death 1 and Programmed Death Ligand 1 Results in Prolonged Survival in Kras/p53-Driven Lung Cancer.Lee JW, Zhang Y, Eoh KJ, Sharma R, Sanmamed MF, Wu J, Choi J, Park HS, Iwasaki A, Kaftan E, Chen L, Papadimitrakopoulou V, Herbst RS, Koo JS. J Thorac Oncol. 2019 Jun; 2019 Feb 13. PMID: 30771521.
Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice.Uraki R, Hastings AK, Marin-Lopez A, Sumida T, Takahashi T, Grover JR, Iwasaki A, Hafler DA, Montgomery RR, Fikrig E. Nat Microbiol. 2019 Jun; 2019 Mar 11. PMID: 30858571.
Monocytes Inadequately Fill In for Meningeal Macrophages.Song E, Iwasaki A. Trends Immunol. 2019 Jun; 2019 May 6. PMID: 31072686.
Low ambient humidity impairs barrier function and innate resistance against influenza infection.Kudo E, Song E, Yockey LJ, Rakib T, Wong PW, Homer RJ, Iwasaki A. Proc Natl Acad Sci U S A. 2019 May 28; 2019 May 13. PMID: 31085641.
YTHDF1 Control of Dendritic Cell Cross-Priming as a Possible Target of Cancer Immunotherapy.Kim DJ, Iwasaki A. Biochemistry. 2019 Apr 16; 2019 Apr 3. PMID: 30943019.
RIG-I Selectively Discriminates against 5'-Monophosphate RNA.Ren X, Linehan MM, Iwasaki A, Pyle AM. Cell Rep. 2019 Feb 19. PMID: 30784585.
The Lupus Susceptibility Locus Sgp3 Encodes the Suppressor of Endogenous Retrovirus Expression SNERV.Treger RS, Pope SD, Kong Y, Tokuyama M, Taura M, Iwasaki A. Immunity. 2019 Feb 19; 2019 Jan 29. PMID: 30709743.
Apobec3A maintains HIV-1 latency through recruitment of epigenetic silencing machinery to the long terminal repeat.Taura M, Song E, Ho YC, Iwasaki A. Proc Natl Acad Sci U S A. 2019 Feb 5; 2019 Jan 22. PMID: 30670656.

2018

ERVmap analysis reveals genome-wide transcription of human endogenous retroviruses.Tokuyama M, Kong Y, Song E, Jayewickreme T, Kang I, Iwasaki A. Proc Natl Acad Sci U S A. 2018 Dec 11; 2018 Nov 19. PMID: 30455304.
Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development.Yockey LJ, Iwasaki A. Immunity. 2018 Sep 18. PMID: 30231982.
Regional Differences in Airway Epithelial Cells Reveal Tradeoff between Defense against Oxidative Stress and Defense against Rhinovirus.Mihaylova VT, Kong Y, Fedorova O, Sharma L, Dela Cruz CS, Pyle AM, Iwasaki A, Foxman EF. Cell Rep. 2018 Sep 11. PMID: 30208323.
An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication.Orzalli MH, Smith A, Jurado KA, Iwasaki A, Garlick JA, Kagan JC. Mol Cell. 2018 Sep 6; 2018 Aug 9. PMID: 30100266.
Critical role of CD4⁺ T cells and IFNγ signaling in antibody-mediated resistance to Zika virus infection.Lucas CGO, Kitoko JZ, Ferreira FM, Suzart VG, Papa MP, Coelho SVA, Cavazzoni CB, Paula-Neto HA, Olsen PC, Iwasaki A, Pereira RM, Pimentel-Coelho PM, Vale AM, de Arruda LB, Bozza MT. Nat Commun. 2018 Aug 7; 2018 Aug 7. PMID: 30087337.
KDM5 histone demethylases repress immune response via suppression of STING.Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall MD, Cheng X, Shadel GS, Yan Q. PLoS Biol. 2018 Aug; 2018 Aug 6. PMID: 30080846.
Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner.Gopinath S, Kim MV, Rakib T, Wong PW, van Zandt M, Barry NA, Kaisho T, Goodman AL, Iwasaki A. Nat Microbiol. 2018 May; 2018 Apr 9. PMID: 29632368.
The interaction between IKKα and LC3 promotes type I interferon production through the TLR9-containing LAPosome.Hayashi K, Taura M, Iwasaki A. Sci Signal. 2018 May 1; 2018 May 1. PMID: 29717061.
A minimal RNA ligand for potent RIG-I activation in living mice.Linehan MM, Dickey TH, Molinari ES, Fitzgerald ME, Potapova O, Iwasaki A, Pyle AM. Sci Adv. 2018 Feb; 2018 Feb 21. PMID: 29492454.
Antiviral CD8 T cells induce Zika-virus-associated paralysis in mice.Jurado KA, Yockey LJ, Wong PW, Lee S, Huttner AJ, Iwasaki A. Nat Microbiol. 2018 Feb; 2017 Nov 20. PMID: 29158604.
Type I interferons instigate fetal demise after Zika virus infection.Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y, Horvath TL, Weatherbee S, Kliman HJ, Coyne CB, Iwasaki A. Sci Immunol. 2018 Jan 5. PMID: 29305462.

2017

Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes.Molony RD, Nguyen JT, Kong Y, Montgomery RR, Shaw AC, Iwasaki A. Sci Signal. 2017 Dec 12; 2017 Dec 12. PMID: 29233916.
The cellular endosomal protein stannin inhibits intracellular trafficking of human papillomavirus during virus entry.Lipovsky A, Erden A, Kanaya E, Zhang W, Crite M, Bradfield C, MacMicking J, DiMaio D, Schoggins JW, Iwasaki A. J Gen Virol. 2017 Nov; 2017 Oct 23. PMID: 29058661.
Zika virus targets blood monocytes.Jurado KA, Iwasaki A. Nat Microbiol. 2017 Nov. PMID: 29070824.
B cells require Type 1 interferon to produce alloantibodies to transfused KEL-expressing red blood cells in mice.Gibb DR, Liu J, Santhanakrishnan M, Natarajan P, Madrid DJ, Patel S, Eisenbarth SC, Tormey CA, Stowell SR, Iwasaki A, Hendrickson JE. Transfusion. 2017 Nov; 2017 Aug 23. PMID: 28836263.
Type I IFN Is Necessary and Sufficient for Inflammation-Induced Red Blood Cell Alloimmunization in Mice.Gibb DR, Liu J, Natarajan P, Santhanakrishnan M, Madrid DJ, Eisenbarth SC, Zimring JC, Iwasaki A, Hendrickson JE. J Immunol. 2017 Aug 1; 2017 Jun 19. PMID: 28630094.
Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.Sasai M, Sakaguchi N, Ma JS, Nakamura S, Kawabata T, Bando H, Lee Y, Saitoh T, Akira S, Iwasaki A, Standley DM, Yoshimori T, Yamamoto M. Nat Immunol. 2017 Aug; 2017 Jun 12. PMID: 28604719.
Sensing Self and Foreign Circular RNAs by Intron Identity.Chen YG, Kim MV, Chen X, Batista PJ, Aoyama S, Wilusz JE, Iwasaki A, Chang HY. Mol Cell. 2017 Jul 20; 2017 Jun 15. PMID: 28625551.
RAB15 empowers dendritic cells to drive antiviral immunity.Wong P, Iwasaki A. Sci Immunol. 2017 Jul 7. PMID: 28783705.
IRE1α promotes viral infection by conferring resistance to apoptosis.Fink SL, Jayewickreme TR, Molony RD, Iwawaki T, Landis CS, Lindenbach BD, Iwasaki A. Sci Signal. 2017 Jun 6; 2017 Jun 6. PMID: 28588082.
Fetal Growth Restriction Caused by Sexual Transmission of Zika Virus in Mice.Uraki R, Jurado KA, Hwang J, Szigeti-Buck K, Horvath TL, Iwasaki A, Fikrig E. J Infect Dis. 2017 Jun 1. PMID: 28472297.
TAM Receptors Are Not Required for Zika Virus Infection in Mice.Hastings AK, Yockey LJ, Jagger BW, Hwang J, Uraki R, Gaitsch HF, Parnell LA, Cao B, Mysorekar IU, Rothlin CV, Fikrig E, Diamond MS, Iwasaki A. Cell Rep. 2017 Apr 18. PMID: 28423319.
Immune Regulation of Antibody Access to Neuronal Tissues.Iwasaki A. Trends Mol Med. 2017 Mar; 2017 Feb 7. PMID: 28185790.
β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares.Goldberg EL, Asher JL, Molony RD, Shaw AC, Zeiss CJ, Wang C, Morozova-Roche LA, Herzog RI, Iwasaki A, Dixit VD. Cell Rep. 2017 Feb 28. PMID: 28249154.
Zika virus causes testicular atrophy.Uraki R, Hwang J, Jurado KA, Householder S, Yockey LJ, Hastings AK, Homer RJ, Iwasaki A, Fikrig E. Sci Adv. 2017 Feb; 2017 Feb 22. PMID: 28261663.
Early local immune defences in the respiratory tract.Iwasaki A, Foxman EF, Molony RD. Nat Rev Immunol. 2017 Jan; 2016 Nov 28. PMID: 27890913.

2016

CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2.Shin H, Kumamoto Y, Gopinath S, Iwasaki A. Nat Commun. 2016 Nov 9; 2016 Nov 9. PMID: 27827367.
CD301b⁺ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens.Kumamoto Y, Hirai T, Wong PW, Kaplan DH, Iwasaki A. Elife. 2016 Sep 22; 2016 Sep 22. PMID: 27657168.
CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha.Kumamoto Y, Camporez JPG, Jurczak MJ, Shanabrough M, Horvath T, Shulman GI, Iwasaki A. Immunity. 2016 Sep 20; 2016 Aug 23. PMID: 27566941.
CD301b+ Macrophages Are Essential for Effective Skin Wound Healing.Shook B, Xiao E, Kumamoto Y, Iwasaki A, Horsley V. J Invest Dermatol. 2016 Sep; 2016 Jun 7. PMID: 27287183.
Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection.Yockey LJ, Varela L, Rakib T, Khoury-Hanold W, Fink SL, Stutz B, Szigeti-Buck K, Van den Pol A, Lindenbach BD, Horvath TL, Iwasaki A. Cell. 2016 Aug 25. PMID: 27565347.
Two interferon-independent double-stranded RNA-induced host defense strategies suppress the common cold virus at warm temperature.Foxman EF, Storer JA, Vanaja K, Levchenko A, Iwasaki A. Proc Natl Acad Sci U S A. 2016 Jul 26; 2016 Jul 11. PMID: 27402752.
AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity.Schmid ET, Pang IK, Carrera Silva EA, Bosurgi L, Miner JJ, Diamond MS, Iwasaki A, Rothlin CV. Elife. 2016 Jun 28; 2016 Jun 28. PMID: 27350258.
Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality.Khoury-Hanold W, Yordy B, Kong P, Kong Y, Ge W, Szigeti-Buck K, Ralevski A, Horvath TL, Iwasaki A. Cell Host Microbe. 2016 Jun 8. PMID: 27281569.
Antiviral responses of inbred mice.Iwasaki A. Nat Rev Immunol. 2016 Jun; 2016 Apr 25. PMID: 27108522.
Access of protective antiviral antibody to neuronal tissues requires CD4 T-cell help.Iijima N, Iwasaki A. Nature. 2016 May 26; 2016 May 18. PMID: 27225131.
Exploiting Mucosal Immunity for Antiviral Vaccines.Iwasaki A. Annu Rev Immunol. 2016 May 20. PMID: 27168245.
Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease.Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, Staeheli P, Iwasaki A. Science. 2016 Apr 22. PMID: 27102485.
O-linked sugars sound the alarm.Gopinath S, Kumamoto Y, Iwasaki A. Nat Immunol. 2016 Feb. PMID: 26784258.
Autophagy Snuffs a Macrophage's Inner Fire.Khoury-Hanold W, Iwasaki A. Cell Host Microbe. 2016 Jan 13. PMID: 26764592.

2015

Toll-like receptor 9 trafficking and signaling for type I interferons requires PIKfyve activity.Hayashi K, Sasai M, Iwasaki A. Int Immunol. 2015 Sep; 2015 Apr 29. PMID: 25925170.
Tissue instruction for migration and retention of TRM cells.Iijima N, Iwasaki A. Trends Immunol. 2015 Sep; 2015 Aug 14. PMID: 26282885.
Balancing family life with a science career.Iwasaki A. Nat Immunol. 2015 Aug. PMID: 26194275.
Cervicovaginal microbiota: simple is better.Gopinath S, Iwasaki A. Immunity. 2015 May 19. PMID: 25992855.
Mitochondrial DNA stress primes the antiviral innate immune response.West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS. Nature. 2015 Apr 23; 2015 Feb 2. PMID: 25642965.
No viral association found in a set of differentiated vulvar intraepithelial neoplasia cases by human papillomavirus and pan-viral microarray testing.Saglam O, Samayoa E, Somasekar S, Naccache S, Iwasaki A, Chiu CY. PLoS One. 2015; 2015 Apr 20. PMID: 25894343.
Control of adaptive immunity by the innate immune system.Iwasaki A, Medzhitov R. Nat Immunol. 2015 Apr. PMID: 25789684.
Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation.Kashem SW, Igyarto BZ, Gerami-Nejad M, Kumamoto Y, Mohammed JA, Jarrett E, Drummond RA, Zurawski SM, Zurawski G, Berman J, Iwasaki A, Brown GD, Kaplan DH. Immunity. 2015 Feb 17; 2015 Feb 10. PMID: 25680275.
Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells.Foxman EF, Storer JA, Fitzgerald ME, Wasik BR, Hou L, Zhao H, Turner PE, Pyle AM, Iwasaki A. Proc Natl Acad Sci U S A. 2015 Jan 20; 2015 Jan 5. PMID: 25561542.
Application of the proximity-dependent assay and fluorescence imaging approaches to study viral entry pathways.Lipovsky A, Zhang W, Iwasaki A, DiMaio D. Methods Mol Biol. 2015. PMID: 25702134.

2014

Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA. Cell. 2014 Dec 18. PMID: 25525875.
T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells.Iijima N, Iwasaki A. Science. 2014 Oct 3; 2014 Aug 28. PMID: 25170048.
Poliomyelitis in transgenic mice expressing CD155 under the control of the Tage4 promoter after oral and parenteral poliovirus inoculation.Khan S, Toyoda H, Linehan M, Iwasaki A, Nomoto A, Bernhardt G, Cello J, Wimmer E. J Gen Virol. 2014 Aug; 2014 Apr 30. PMID: 24784416.
Innate immunity to influenza virus infection.Iwasaki A, Pillai PS. Nat Rev Immunol. 2014 May. PMID: 24762827.
Alternative capture of noncoding RNAs or protein-coding genes by herpesviruses to alter host T cell function.Guo YE, Riley KJ, Iwasaki A, Steitz JA. Mol Cell. 2014 Apr 10. PMID: 24725595.
A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction.Bonham KS, Orzalli MH, Hayashi K, Wolf AI, Glanemann C, Weninger W, Iwasaki A, Knipe DM, Kagan JC. Cell. 2014 Feb 13. PMID: 24529375.
Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth.Ding S, Khoury-Hanold W, Iwasaki A, Robek MD. PLoS Biol. 2014 Jan; 2014 Jan 7. PMID: 24409098.

2013

ELF4 is critical for induction of type I interferon and the host antiviral response.You F, Wang P, Yang L, Yang G, Zhao YO, Qian F, Walker W, Sutton R, Montgomery R, Lin R, Iwasaki A, Fikrig E. Nat Immunol. 2013 Dec; 2013 Nov 3. PMID: 24185615.
CD301b⁺ dermal dendritic cells drive T helper 2 cell-mediated immunity.Kumamoto Y, Linehan M, Weinstein JS, Laidlaw BJ, Craft JE, Iwasaki A. Immunity. 2013 Oct 17; 2013 Sep 26. PMID: 24076051.
Generating protective immunity against genital herpes.Shin H, Iwasaki A. Trends Immunol. 2013 Oct; 2013 Sep 3. PMID: 24012144.
Tissue-resident memory T cells.Shin H, Iwasaki A. Immunol Rev. 2013 Sep. PMID: 23947354.
High-risk human papillomavirus E6 inhibits monocyte differentiation to Langerhans cells.Iijima N, Goodwin EC, Dimaio D, Iwasaki A. Virology. 2013 Sep; 2013 Jul 18. PMID: 23871219.
Efficient influenza A virus replication in the respiratory tract requires signals from TLR7 and RIG-I.Pang IK, Pillai PS, Iwasaki A. Proc Natl Acad Sci U S A. 2013 Aug 20; 2013 Aug 5. PMID: 23918369.
Parvovirus evades interferon-dependent viral control in primary mouse embryonic fibroblasts.Mattei LM, Cotmore SF, Tattersall P, Iwasaki A. Virology. 2013 Jul 20; 2013 May 12. PMID: 23676303.
Toll-like receptor 9 in plasmacytoid dendritic cells fails to detect parvoviruses.Mattei LM, Cotmore SF, Li L, Tattersall P, Iwasaki A. J Virol. 2013 Mar; 2013 Jan 9. PMID: 23302877.