Publications

2021

Neuroinvasion of SARS-CoV-2 in human and mouse brain.Song E, Zhang C, Israelow B, Lu-Culligan A, Prado AV, Skriabine S, Lu P, Weizman OE, Liu F, Dai Y, Szigeti-Buck K, Yasumoto Y, Wang G, Castaldi C, Heltke J, Ng E, Wheeler J, Alfajaro MM, Levavasseur E, Fontes B, Ravindra NG, Van Dijk D, Mane S, Gunel M, Ring A, Kazmi SAJ, Zhang K, Wilen CB, Horvath TL, Plu I, Haik S, Thomas JL, Louvi A, Farhadian SF, Huttner A, Seilhean D, Renier N, Bilguvar K, Iwasaki A. J Exp Med. 2021 Mar 1. PMID: 33433624.
Saliva viral load is a dynamic unifying correlate of COVID-19 severity and mortality.Silva J, Lucas C, Sundaram M, Israelow B, Wong P, Klein J, Tokuyama M, Lu P, Venkataraman A, Liu F, Mao T, Oh JE, Park A, Casanovas-Massana A, Vogels CBF, Muenker CM, Zell J, Fournier JB, Campbell M, Chiorazzi M, Ruiz Fuentes E, Petrone M, Kalinich CC, Ott IM, Watkins A, Moore AJ, Nakahata MI, Grubaugh ND, Farhadian S, Dela Cruz C, Ko A, Schulz WL, Ring AM, Ma S, Omer S, Wyllie AL, Iwasaki A. medRxiv. 2021 Jan 10; 2021 Jan 10. PMID: 33442706.
What reinfections mean for COVID-19.Iwasaki A. Lancet Infect Dis. 2021 Jan; 2020 Oct 12. PMID: 33058796.

2020

Kinetics of antibody responses dictate COVID-19 outcome.Lucas C, Klein J, Sundaram M, Liu F, Wong P, Silva J, Mao T, Oh JE, Tokuyama M, Lu P, Venkataraman A, Park A, Israelow B, Wyllie AL, Vogels CBF, Muenker MC, Casanovas-Massana A, Schulz WL, Zell J, Campbell M, Fournier JB, Grubaugh ND, Farhadian S, Wisnewski AV, Cruz CD, Omer S, Ko AI, Ring A, Iwasaki A. medRxiv. 2020 Dec 22; 2020 Dec 22. PMID: 33398304.
The Global Response to the COVID-19 Pandemic.Nkengasong J, Iwasaki A, Victora C, Oh J, Gao GF, Agrawal A, Drosten C, Söderberg-Naucler C, López-Collazo E, Pollock AM, Viola A, Baker M. Med (N Y). 2020 Dec 18. PMID: 33363282.
Diverse Functional Autoantibodies in Patients with COVID-19.Wang EY, Mao T, Klein J, Dai Y, Huck JD, Liu F, Zheng NS, Zhou T, Israelow B, Wong P, Lucas C, Silva J, Oh JE, Song E, Perotti ES, Fischer S, Campbell M, Fournier JB, Wyllie AL, Vogels CBF, Ott IM, Kalinich CC, Petrone ME, Watkins AE, Cruz CD, Farhadian SF, Schulz WL, Grubaugh ND, Ko AI, Iwasaki A, Ring AM. medRxiv. 2020 Dec 12; 2020 Dec 12. PMID: 33330894.
Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling.Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. J Exp Med. 2020 Dec 7. PMID: 32750141.
Sex differences in immune responses that underlie COVID-19 disease outcomes.Takahashi T, Ellingson MK, Wong P, Israelow B, Lucas C, Klein J, Silva J, Mao T, Oh JE, Tokuyama M, Lu P, Venkataraman A, Park A, Liu F, Meir A, Sun J, Wang EY, Casanovas-Massana A, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott IM, Moore AJ, Shaw A, Fournier JB, Odio CD, Farhadian S, Dela Cruz C, Grubaugh ND, Schulz WL, Ring AM, Ko AI, Omer SB, Iwasaki A. Nature. 2020 Dec; 2020 Aug 26. PMID: 32846427.
Commensal Microbiota Modulation of Natural Resistance to Virus Infection.Stefan KL, Kim MV, Iwasaki A, Kasper DL. Cell. 2020 Nov 25; 2020 Nov 18. PMID: 33212011.
Interferon deficiency can lead to severe COVID.Meffre E, Iwasaki A. Nature. 2020 Nov. PMID: 33139913.
RUNX Binding Sites Are Enriched in Herpesvirus Genomes, and RUNX1 Overexpression Leads to Herpes Simplex Virus 1 Suppression.Kim DJ, Khoury-Hanold W, Jain PC, Klein J, Kong Y, Pope SD, Ge W, Medzhitov R, Iwasaki A. J Virol. 2020 Oct 27; 2020 Oct 27. PMID: 32878886.
Why and How Vaccines Work.Iwasaki A, Omer SB. Cell. 2020 Oct 15. PMID: 33064982.
Detection of SARS-CoV-2 RNA by multiplex RT-qPCR.Kudo E, Israelow B, Vogels CBF, Lu P, Wyllie AL, Tokuyama M, Venkataraman A, Brackney DE, Ott IM, Petrone ME, Earnest R, Lapidus S, Muenker MC, Moore AJ, Casanovas-Massana A, Omer SB, Dela Cruz CS, Farhadian SF, Ko AI, Grubaugh ND, Iwasaki A. PLoS Biol. 2020 Oct; 2020 Oct 7. PMID: 33027248.
The Role of Immune Factors in Shaping Fetal Neurodevelopment.Lu-Culligan A, Iwasaki A. Annu Rev Cell Dev Biol. 2020 Oct 6; 2020 Jul 28. PMID: 32722920.
Analytical sensitivity and efficiency comparisons of SARS-CoV-2 RT-qPCR primer-probe sets.Vogels CBF, Brito AF, Wyllie AL, Fauver JR, Ott IM, Kalinich CC, Petrone ME, Casanovas-Massana A, Catherine Muenker M, Moore AJ, Klein J, Lu P, Lu-Culligan A, Jiang X, Kim DJ, Kudo E, Mao T, Moriyama M, Oh JE, Park A, Silva J, Song E, Takahashi T, Taura M, Tokuyama M, Venkataraman A, Weizman OE, Wong P, Yang Y, Cheemarla NR, White EB, Lapidus S, Earnest R, Geng B, Vijayakumar P, Odio C, Fournier J, Bermejo S, Farhadian S, Dela Cruz CS, Iwasaki A, Ko AI, Landry ML, Foxman EF, Grubaugh ND. Nat Microbiol. 2020 Oct; 2020 Jul 10. PMID: 32651556.
Seasonality of Respiratory Viral Infections.Moriyama M, Hugentobler WJ, Iwasaki A. Annu Rev Virol. 2020 Sep 29; 2020 Mar 20. PMID: 32196426.
Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2.Wyllie AL, Fournier J, Casanovas-Massana A, Campbell M, Tokuyama M, Vijayakumar P, Warren JL, Geng B, Muenker MC, Moore AJ, Vogels CBF, Petrone ME, Ott IM, Lu P, Venkataraman A, Lu-Culligan A, Klein J, Earnest R, Simonov M, Datta R, Handoko R, Naushad N, Sewanan LR, Valdez J, White EB, Lapidus S, Kalinich CC, Jiang X, Kim DJ, Kudo E, Linehan M, Mao T, Moriyama M, Oh JE, Park A, Silva J, Song E, Takahashi T, Taura M, Weizman OE, Wong P, Yang Y, Bermejo S, Odio CD, Omer SB, Dela Cruz CS, Farhadian S, Martinello RA, Iwasaki A, Grubaugh ND, Ko AI. N Engl J Med. 2020 Sep 24; 2020 Aug 28. PMID: 32857487.
Immunologically distinct responses occur in the CNS of COVID-19 patients.Song E, Chow RD, Jiang R, Zamecnik CR, Loudermilk RP, Dai Y, Liu F, Geng B, Chiarella J, Israelow B, Casanovas-Massana A, Ko AI, Ring A, Kleinstein SH, Spudich S, Wilson MR, Iwasaki A, Farhadian SF. bioRxiv. 2020 Sep 12; 2020 Sep 12. PMID: 32935102.
Tracking Smell Loss to Identify Healthcare Workers with SARS-CoV-2 Infection.Weiss JJ, Attuquayefio TN, White EB, Li F, Herz RS, White TL, Campbell M, Geng B, Datta R, Wyllie AL, Grubaugh ND, Casanovas-Massana A, Muenker MC, Handoko R, Iwasaki A, Martinello RA, Ko AI, Small DM, Farhadian SF. medRxiv. 2020 Sep 10; 2020 Sep 10. PMID: 32935121.
Neuroinvasion of SARS-CoV-2 in human and mouse brain.Song E, Zhang C, Israelow B, Lu-Culligan A, Prado AV, Skriabine S, Lu P, Weizman OE, Liu F, Dai Y, Szigeti-Buck K, Yasumoto Y, Wang G, Castaldi C, Heltke J, Ng E, Wheeler J, Alfajaro MM, Levavasseur E, Fontes B, Ravindra NG, Van Dijk D, Mane S, Gunel M, Ring A, Jaffar Kazmi SA, Zhang K, Wilen CB, Horvath TL, Plu I, Haik S, Thomas JL, Louvi A, Farhadian SF, Huttner A, Seilhean D, Renier N, Bilguvar K, Iwasaki A. bioRxiv. 2020 Sep 8; 2020 Sep 8. PMID: 32935108.
Kynurenic acid underlies sex-specific immune responses to COVID-19.Cai Y, Kim DJ, Takahashi T, Broadhurst DI, Ma S, Rattray NJW, Casanovas-Massana A, Israelow B, Klein J, Lucas C, Mao T, Moore AJ, Muenker CM, Silva J, Wong P, Ko AJ, Khan SA, Iwasaki A, Johnson CH. medRxiv. 2020 Sep 8; 2020 Sep 8. PMID: 32935119.
Pooling saliva to increase SARS-CoV-2 testing capacity.Watkins AE, Fenichel EP, Weinberger DM, Vogels CBF, Brackney DE, Casanovas-Massana A, Campbell M, Fournier J, Bermejo S, Datta R, Dela Cruz CS, Farhadian SF, Iwasaki A, Ko AI, Grubaugh ND, Wyllie AL. medRxiv. 2020 Sep 3; 2020 Sep 3. PMID: 32909003.
SARS-CoV-2 infection of the placenta.Hosier H, Farhadian SF, Morotti RA, Deshmukh U, Lu-Culligan A, Campbell KH, Yasumoto Y, Vogels CB, Casanovas-Massana A, Vijayakumar P, Geng B, Odio CD, Fournier J, Brito AF, Fauver JR, Liu F, Alpert T, Tal R, Szigeti-Buck K, Perincheri S, Larsen C, Gariepy AM, Aguilar G, Fardelmann KL, Harigopal M, Taylor HS, Pettker CM, Wyllie AL, Cruz CD, Ring AM, Grubaugh ND, Ko AI, Horvath TL, Iwasaki A, Reddy UM, Lipkind HS. J Clin Invest. 2020 Sep 1. PMID: 32573498.
Simply saliva: stability of SARS-CoV-2 detection negates the need for expensive collection devices.Ott IM, Strine MS, Watkins AE, Boot M, Kalinich CC, Harden CA, Vogels CBF, Casanovas-Massana A, Moore AJ, Muenker MC, Nakahata M, Tokuyama M, Nelson A, Fournier J, Bermejo S, Campbell M, Datta R, Dela Cruz CS, Farhadian SF, Ko AI, Iwasaki A, Grubaugh ND, Wilen CB, Wyllie AL. medRxiv. 2020 Aug 4; 2020 Aug 4. PMID: 32793924.
[Meningeal lymphatics, a potential target for the treatment of brain tumors].Thomas JL, Song E, Boisserand L, Iwasaki A. Med Sci (Paris). 2020 Aug-Sep; 2020 Aug 21. PMID: 32821046.
Longitudinal analyses reveal immunological misfiring in severe COVID-19.Lucas C, Wong P, Klein J, Castro TBR, Silva J, Sundaram M, Ellingson MK, Mao T, Oh JE, Israelow B, Takahashi T, Tokuyama M, Lu P, Venkataraman A, Park A, Mohanty S, Wang H, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott IM, Moore AJ, Muenker MC, Fournier JB, Campbell M, Odio CD, Casanovas-Massana A, Herbst R, Shaw AC, Medzhitov R, Schulz WL, Grubaugh ND, Dela Cruz C, Farhadian S, Ko AI, Omer SB, Iwasaki A. Nature. 2020 Aug; 2020 Jul 27. PMID: 32717743.
Clinical Characteristics and Outcomes for 7,995 Patients with SARS-CoV-2 Infection.McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJ, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ Jr, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. medRxiv. 2020 Jul 21; 2020 Jul 21. PMID: 32743602.
Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19.Yap JKY, Moriyama M, Iwasaki A. J Immunol. 2020 Jul 15; 2020 Jun 3. PMID: 32493814.
Vitamin B12 and folic acid alleviate symptoms of nutritional deficiency by antagonizing aryl hydrocarbon receptor.Kim DJ, Venkataraman A, Jain PC, Wiesler EP, DeBlasio M, Klein J, Tu SS, Lee S, Medzhitov R, Iwasaki A. Proc Natl Acad Sci U S A. 2020 Jul 7; 2020 Jun 22. PMID: 32571957.
m⁶A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development.Gao Y, Vasic R, Song Y, Teng R, Liu C, Gbyli R, Biancon G, Nelakanti R, Lobben K, Kudo E, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, Lee V, Dura B, Viero G, Iwasaki A, Fan R, Xiao A, Flavell RA, Li HB, Tebaldi T, Halene S. Immunity. 2020 Jun 16; 2020 Jun 3. PMID: 32497523.
Mouse Model of SARS-CoV-2 Reveals Inflammatory Role of Type I Interferon Signaling.Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. SSRN. 2020 Jun 16; 2020 Jun 16. PMID: 32714125.
Type I and Type III Interferons - Induction, Signaling, Evasion, and Application to Combat COVID-19.Park A, Iwasaki A. Cell Host Microbe. 2020 Jun 10; 2020 May 27. PMID: 32464097.
Sex differences in immune responses to SARS-CoV-2 that underlie disease outcomes.Takahashi T, Wong P, Ellingson MK, Lucas C, Klein J, Israelow B, Silva J, Oh JE, Mao T, Tokuyama M, Lu P, Venkataraman A, Park A, Liu F, Meir A, Sun J, Wang EY, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott IM, Moore AJ, Casanovas-Massana A, Cruz CD, Fournier JB, Odio CD, Farhadian S, Grubaugh ND, Schulz WL, Ko AI, Ring AM, Omer SB, Iwasaki A. medRxiv. 2020 Jun 9; 2020 Jun 9. PMID: 32577695.
The potential danger of suboptimal antibody responses in COVID-19.Iwasaki A, Yang Y. Nat Rev Immunol. 2020 Jun. PMID: 32317716.
Coast-to-Coast Spread of SARS-CoV-2 during the Early Epidemic in the United States.Fauver JR, Petrone ME, Hodcroft EB, Shioda K, Ehrlich HY, Watts AG, Vogels CBF, Brito AF, Alpert T, Muyombwe A, Razeq J, Downing R, Cheemarla NR, Wyllie AL, Kalinich CC, Ott IM, Quick J, Loman NJ, Neugebauer KM, Greninger AL, Jerome KR, Roychoudhury P, Xie H, Shrestha L, Huang ML, Pitzer VE, Iwasaki A, Omer SB, Khan K, Bogoch II, Martinello RA, Foxman EF, Landry ML, Neher RA, Ko AI, Grubaugh ND. Cell. 2020 May 28; 2020 May 7. PMID: 32386545.
Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling.Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. bioRxiv. 2020 May 27; 2020 May 27. PMID: 32577647.
Why does Japan have so few cases of COVID-19?Iwasaki A, Grubaugh ND. EMBO Mol Med. 2020 May 8; 2020 Apr 28. PMID: 32275804.
Contributions of maternal and fetal antiviral immunity in congenital disease.Yockey LJ, Lucas C, Iwasaki A. Science. 2020 May 8. PMID: 32381717.
Single-cell longitudinal analysis of SARS-CoV-2 infection in human bronchial epithelial cells.Ravindra NG, Alfajaro MM, Gasque V, Wei J, Filler RB, Huston NC, Wan H, Szigeti-Buck K, Wang B, Montgomery RR, Eisenbarth SC, Williams A, Pyle AM, Iwasaki A, Horvath TL, Foxman EF, van Dijk D, Wilen CB. bioRxiv. 2020 May 7; 2020 May 7. PMID: 32511382.
Cutting Edge: The Use of Topical Aminoglycosides as an Effective Pull in "Prime and Pull" Vaccine Strategy.Gopinath S, Lu P, Iwasaki A. J Immunol. 2020 Apr 1; 2020 Mar 2. PMID: 32122994.
Antidote to toxic principal investigators.Iwasaki A. Nat Med. 2020 Apr. PMID: 32273601.
Coast-to-coast spread of SARS-CoV-2 in the United States revealed by genomic epidemiology.Fauver JR, Petrone ME, Hodcroft EB, Shioda K, Ehrlich HY, Watts AG, Vogels CBF, Brito AF, Alpert T, Muyombwe A, Razeq J, Downing R, Cheemarla NR, Wyllie AL, Kalinich CC, Ott I, Quick J, Loman NJ, Neugebauer KM, Greninger AL, Jerome KR, Roychoundhury P, Xie H, Shrestha L, Huang ML, Pitzer VE, Iwasaki A, Omer SB, Khan K, Bogoch I, Martinello RA, Foxman EF, Landry ML, Neher RA, Ko AI, Grubaugh ND. medRxiv. 2020 Mar 26; 2020 Mar 26. PMID: 32511630.
VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours.Song E, Mao T, Dong H, Boisserand LSB, Antila S, Bosenberg M, Alitalo K, Thomas JL, Iwasaki A. Nature. 2020 Jan; 2020 Jan 15. PMID: 31942068.

2019

RIG-I Recognition of RNA Targets: The Influence of Terminal Base Pair Sequence and Overhangs on Affinity and Signaling.Ren X, Linehan MM, Iwasaki A, Pyle AM. Cell Rep. 2019 Dec 17. PMID: 31851914.
Universal Principled Review: A Community-Driven Method to Improve Peer Review.Krummel M, Blish C, Kuhns M, Cadwell K, Oberst A, Goldrath A, Ansel KM, Chi H, O'Connell R, Wherry EJ, Pepper M. Cell. 2019 Dec 12. PMID: 31835023.
Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses.Jiang X, Muthusamy V, Fedorova O, Kong Y, Kim DJ, Bosenberg M, Pyle AM, Iwasaki A. J Exp Med. 2019 Dec 2; 2019 Oct 10. PMID: 31601678.
Ketogenic diet activates protective γδ T cell responses against influenza virus infection.Goldberg EL, Molony RD, Kudo E, Sidorov S, Kong Y, Dixit VD, Iwasaki A. Sci Immunol. 2019 Nov 15. PMID: 31732517.
Murine Leukemia Virus Exploits Innate Sensing by Toll-Like Receptor 7 in B-1 Cells To Establish Infection and Locally Spread in Mice.Pi R, Iwasaki A, Sewald X, Mothes W, Uchil PD. J Virol. 2019 Nov 1; 2019 Oct 15. PMID: 31434732.
Human APOBEC3G Prevents Emergence of Infectious Endogenous Retrovirus in Mice.Treger RS, Tokuyama M, Dong H, Salas-Briceno K, Ross SR, Kong Y, Iwasaki A. J Virol. 2019 Oct 15; 2019 Sep 30. PMID: 31341050.
Why we need to increase diversity in the immunology research community.Iwasaki A. Nat Immunol. 2019 Sep. PMID: 31427777.
Effector T_H17 Cells Give Rise to Long-Lived T_RM Cells that Are Essential for an Immediate Response against Bacterial Infection.Amezcua Vesely MC, Pallis P, Bielecki P, Low JS, Zhao J, Harman CCD, Kroehling L, Jackson R, Bailis W, Licona-Limón P, Xu H, Iijima N, Pillai PS, Kaplan DH, Weaver CT, Kluger Y, Kowalczyk MS, Iwasaki A, Pereira JP, Esplugues E, Gagliani N, Flavell RA. Cell. 2019 Aug 22. PMID: 31442406.
Successful application of prime and pull strategy for a therapeutic HSV vaccine.Bernstein DI, Cardin RD, Bravo FJ, Awasthi S, Lu P, Pullum DA, Dixon DA, Iwasaki A, Friedman HM. NPJ Vaccines. 2019; 2019 Aug 1. PMID: 31396405.
Migrant memory B cells secrete luminal antibody in the vagina.Oh JE, Iijima N, Song E, Lu P, Klein J, Jiang R, Kleinstein SH, Iwasaki A. Nature. 2019 Jul; 2019 Jun 12. PMID: 31189952.
The Combination of MEK Inhibitor With Immunomodulatory Antibodies Targeting Programmed Death 1 and Programmed Death Ligand 1 Results in Prolonged Survival in Kras/p53-Driven Lung Cancer.Lee JW, Zhang Y, Eoh KJ, Sharma R, Sanmamed MF, Wu J, Choi J, Park HS, Iwasaki A, Kaftan E, Chen L, Papadimitrakopoulou V, Herbst RS, Koo JS. J Thorac Oncol. 2019 Jun; 2019 Feb 13. PMID: 30771521.
Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice.Uraki R, Hastings AK, Marin-Lopez A, Sumida T, Takahashi T, Grover JR, Iwasaki A, Hafler DA, Montgomery RR, Fikrig E. Nat Microbiol. 2019 Jun; 2019 Mar 11. PMID: 30858571.
Monocytes Inadequately Fill In for Meningeal Macrophages.Song E, Iwasaki A. Trends Immunol. 2019 Jun; 2019 May 6. PMID: 31072686.
Low ambient humidity impairs barrier function and innate resistance against influenza infection.Kudo E, Song E, Yockey LJ, Rakib T, Wong PW, Homer RJ, Iwasaki A. Proc Natl Acad Sci U S A. 2019 May 28; 2019 May 13. PMID: 31085641.
YTHDF1 Control of Dendritic Cell Cross-Priming as a Possible Target of Cancer Immunotherapy.Kim DJ, Iwasaki A. Biochemistry. 2019 Apr 16; 2019 Apr 3. PMID: 30943019.
RIG-I Selectively Discriminates against 5'-Monophosphate RNA.Ren X, Linehan MM, Iwasaki A, Pyle AM. Cell Rep. 2019 Feb 19. PMID: 30784585.
The Lupus Susceptibility Locus Sgp3 Encodes the Suppressor of Endogenous Retrovirus Expression SNERV.Treger RS, Pope SD, Kong Y, Tokuyama M, Taura M, Iwasaki A. Immunity. 2019 Feb 19; 2019 Jan 29. PMID: 30709743.
Apobec3A maintains HIV-1 latency through recruitment of epigenetic silencing machinery to the long terminal repeat.Taura M, Song E, Ho YC, Iwasaki A. Proc Natl Acad Sci U S A. 2019 Feb 5; 2019 Jan 22. PMID: 30670656.

2018

ERVmap analysis reveals genome-wide transcription of human endogenous retroviruses.Tokuyama M, Kong Y, Song E, Jayewickreme T, Kang I, Iwasaki A. Proc Natl Acad Sci U S A. 2018 Dec 11; 2018 Nov 19. PMID: 30455304.
Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development.Yockey LJ, Iwasaki A. Immunity. 2018 Sep 18. PMID: 30231982.
Regional Differences in Airway Epithelial Cells Reveal Tradeoff between Defense against Oxidative Stress and Defense against Rhinovirus.Mihaylova VT, Kong Y, Fedorova O, Sharma L, Dela Cruz CS, Pyle AM, Iwasaki A, Foxman EF. Cell Rep. 2018 Sep 11. PMID: 30208323.
An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication.Orzalli MH, Smith A, Jurado KA, Iwasaki A, Garlick JA, Kagan JC. Mol Cell. 2018 Sep 6; 2018 Aug 9. PMID: 30100266.
Critical role of CD4⁺ T cells and IFNγ signaling in antibody-mediated resistance to Zika virus infection.Lucas CGO, Kitoko JZ, Ferreira FM, Suzart VG, Papa MP, Coelho SVA, Cavazzoni CB, Paula-Neto HA, Olsen PC, Iwasaki A, Pereira RM, Pimentel-Coelho PM, Vale AM, de Arruda LB, Bozza MT. Nat Commun. 2018 Aug 7; 2018 Aug 7. PMID: 30087337.
KDM5 histone demethylases repress immune response via suppression of STING.Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall MD, Cheng X, Shadel GS, Yan Q. PLoS Biol. 2018 Aug; 2018 Aug 6. PMID: 30080846.
Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner.Gopinath S, Kim MV, Rakib T, Wong PW, van Zandt M, Barry NA, Kaisho T, Goodman AL, Iwasaki A. Nat Microbiol. 2018 May; 2018 Apr 9. PMID: 29632368.
The interaction between IKKα and LC3 promotes type I interferon production through the TLR9-containing LAPosome.Hayashi K, Taura M, Iwasaki A. Sci Signal. 2018 May 1; 2018 May 1. PMID: 29717061.
A minimal RNA ligand for potent RIG-I activation in living mice.Linehan MM, Dickey TH, Molinari ES, Fitzgerald ME, Potapova O, Iwasaki A, Pyle AM. Sci Adv. 2018 Feb; 2018 Feb 21. PMID: 29492454.
Antiviral CD8 T cells induce Zika-virus-associated paralysis in mice.Jurado KA, Yockey LJ, Wong PW, Lee S, Huttner AJ, Iwasaki A. Nat Microbiol. 2018 Feb; 2017 Nov 20. PMID: 29158604.
Type I interferons instigate fetal demise after Zika virus infection.Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y, Horvath TL, Weatherbee S, Kliman HJ, Coyne CB, Iwasaki A. Sci Immunol. 2018 Jan 5. PMID: 29305462.

2017

Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes.Molony RD, Nguyen JT, Kong Y, Montgomery RR, Shaw AC, Iwasaki A. Sci Signal. 2017 Dec 12; 2017 Dec 12. PMID: 29233916.
The cellular endosomal protein stannin inhibits intracellular trafficking of human papillomavirus during virus entry.Lipovsky A, Erden A, Kanaya E, Zhang W, Crite M, Bradfield C, MacMicking J, DiMaio D, Schoggins JW, Iwasaki A. J Gen Virol. 2017 Nov; 2017 Oct 23. PMID: 29058661.
Zika virus targets blood monocytes.Jurado KA, Iwasaki A. Nat Microbiol. 2017 Nov. PMID: 29070824.
B cells require Type 1 interferon to produce alloantibodies to transfused KEL-expressing red blood cells in mice.Gibb DR, Liu J, Santhanakrishnan M, Natarajan P, Madrid DJ, Patel S, Eisenbarth SC, Tormey CA, Stowell SR, Iwasaki A, Hendrickson JE. Transfusion. 2017 Nov; 2017 Aug 23. PMID: 28836263.
Type I IFN Is Necessary and Sufficient for Inflammation-Induced Red Blood Cell Alloimmunization in Mice.Gibb DR, Liu J, Natarajan P, Santhanakrishnan M, Madrid DJ, Eisenbarth SC, Zimring JC, Iwasaki A, Hendrickson JE. J Immunol. 2017 Aug 1; 2017 Jun 19. PMID: 28630094.
Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.Sasai M, Sakaguchi N, Ma JS, Nakamura S, Kawabata T, Bando H, Lee Y, Saitoh T, Akira S, Iwasaki A, Standley DM, Yoshimori T, Yamamoto M. Nat Immunol. 2017 Aug; 2017 Jun 12. PMID: 28604719.
Sensing Self and Foreign Circular RNAs by Intron Identity.Chen YG, Kim MV, Chen X, Batista PJ, Aoyama S, Wilusz JE, Iwasaki A, Chang HY. Mol Cell. 2017 Jul 20; 2017 Jun 15. PMID: 28625551.
RAB15 empowers dendritic cells to drive antiviral immunity.Wong P, Iwasaki A. Sci Immunol. 2017 Jul 7. PMID: 28783705.
IRE1α promotes viral infection by conferring resistance to apoptosis.Fink SL, Jayewickreme TR, Molony RD, Iwawaki T, Landis CS, Lindenbach BD, Iwasaki A. Sci Signal. 2017 Jun 6; 2017 Jun 6. PMID: 28588082.
Fetal Growth Restriction Caused by Sexual Transmission of Zika Virus in Mice.Uraki R, Jurado KA, Hwang J, Szigeti-Buck K, Horvath TL, Iwasaki A, Fikrig E. J Infect Dis. 2017 Jun 1. PMID: 28472297.
TAM Receptors Are Not Required for Zika Virus Infection in Mice.Hastings AK, Yockey LJ, Jagger BW, Hwang J, Uraki R, Gaitsch HF, Parnell LA, Cao B, Mysorekar IU, Rothlin CV, Fikrig E, Diamond MS, Iwasaki A. Cell Rep. 2017 Apr 18. PMID: 28423319.
Immune Regulation of Antibody Access to Neuronal Tissues.Iwasaki A. Trends Mol Med. 2017 Mar; 2017 Feb 7. PMID: 28185790.
β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares.Goldberg EL, Asher JL, Molony RD, Shaw AC, Zeiss CJ, Wang C, Morozova-Roche LA, Herzog RI, Iwasaki A, Dixit VD. Cell Rep. 2017 Feb 28. PMID: 28249154.
Zika virus causes testicular atrophy.Uraki R, Hwang J, Jurado KA, Householder S, Yockey LJ, Hastings AK, Homer RJ, Iwasaki A, Fikrig E. Sci Adv. 2017 Feb; 2017 Feb 22. PMID: 28261663.
Early local immune defences in the respiratory tract.Iwasaki A, Foxman EF, Molony RD. Nat Rev Immunol. 2017 Jan; 2016 Nov 28. PMID: 27890913.

2016

CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2.Shin H, Kumamoto Y, Gopinath S, Iwasaki A. Nat Commun. 2016 Nov 9; 2016 Nov 9. PMID: 27827367.
CD301b⁺ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens.Kumamoto Y, Hirai T, Wong PW, Kaplan DH, Iwasaki A. Elife. 2016 Sep 22; 2016 Sep 22. PMID: 27657168.
CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha.Kumamoto Y, Camporez JPG, Jurczak MJ, Shanabrough M, Horvath T, Shulman GI, Iwasaki A. Immunity. 2016 Sep 20; 2016 Aug 23. PMID: 27566941.
CD301b+ Macrophages Are Essential for Effective Skin Wound Healing.Shook B, Xiao E, Kumamoto Y, Iwasaki A, Horsley V. J Invest Dermatol. 2016 Sep; 2016 Jun 7. PMID: 27287183.
Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection.Yockey LJ, Varela L, Rakib T, Khoury-Hanold W, Fink SL, Stutz B, Szigeti-Buck K, Van den Pol A, Lindenbach BD, Horvath TL, Iwasaki A. Cell. 2016 Aug 25. PMID: 27565347.
Two interferon-independent double-stranded RNA-induced host defense strategies suppress the common cold virus at warm temperature.Foxman EF, Storer JA, Vanaja K, Levchenko A, Iwasaki A. Proc Natl Acad Sci U S A. 2016 Jul 26; 2016 Jul 11. PMID: 27402752.
AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity.Schmid ET, Pang IK, Carrera Silva EA, Bosurgi L, Miner JJ, Diamond MS, Iwasaki A, Rothlin CV. Elife. 2016 Jun 28; 2016 Jun 28. PMID: 27350258.
Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality.Khoury-Hanold W, Yordy B, Kong P, Kong Y, Ge W, Szigeti-Buck K, Ralevski A, Horvath TL, Iwasaki A. Cell Host Microbe. 2016 Jun 8. PMID: 27281569.
Antiviral responses of inbred mice.Iwasaki A. Nat Rev Immunol. 2016 Jun; 2016 Apr 25. PMID: 27108522.
Access of protective antiviral antibody to neuronal tissues requires CD4 T-cell help.Iijima N, Iwasaki A. Nature. 2016 May 26; 2016 May 18. PMID: 27225131.
Exploiting Mucosal Immunity for Antiviral Vaccines.Iwasaki A. Annu Rev Immunol. 2016 May 20. PMID: 27168245.
Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease.Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, Staeheli P, Iwasaki A. Science. 2016 Apr 22. PMID: 27102485.
O-linked sugars sound the alarm.Gopinath S, Kumamoto Y, Iwasaki A. Nat Immunol. 2016 Feb. PMID: 26784258.