2017
β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares
Goldberg EL, Asher JL, Molony RD, Shaw AC, Zeiss CJ, Wang C, Morozova-Roche LA, Herzog RI, Iwasaki A, Dixit VD. β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares. Cell Reports 2017, 18: 2077-2087. PMID: 28249154, PMCID: PMC5527297, DOI: 10.1016/j.celrep.2017.02.004.Peer-Reviewed Original ResearchConceptsKetogenic dietGouty flaresΒ-hydroxybutyrateMajor risk factorAnti-inflammatory moleculesNLRP3-dependent mannerAlternate metabolic fuelsGout flaresJoint destructionIL-1βIntense painInterleukin-1βNLRP3 inflammasomeRisk factorsInflammatory neutrophilsBacterial infectionsNeutrophilsNLRP3Immune defenseGoutMetabolic fuelsBHBS100A9 fibrilsDietPain
2010
Inflammasomes as mediators of immunity against influenza virus
Pang IK, Iwasaki A. Inflammasomes as mediators of immunity against influenza virus. Trends In Immunology 2010, 32: 34-41. PMID: 21147034, PMCID: PMC3017631, DOI: 10.1016/j.it.2010.11.004.Peer-Reviewed Original ResearchConceptsToll-like receptor 7Influenza virusMediators of immunityInfluenza virus infectionHuman respiratory infectionsRetinoic acid-inducible gene IAcid-inducible gene IInducible gene IInnate immune systemAdaptive immune defenseEndosomal recognitionInnate detectionRespiratory infectionsReceptor 7Virus infectionCytosolic recognitionInflammasome activationLike receptorsImmune systemImmune defenseMajor causeGene IVirusSuch activationMultiple mechanisms
2008
Dendritic cells and macrophages in the genitourinary tract
Iijima N, Thompson J, Iwasaki A. Dendritic cells and macrophages in the genitourinary tract. Mucosal Immunology 2008, 1: 451-459. PMID: 19079212, PMCID: PMC2684461, DOI: 10.1038/mi.2008.57.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsDendritic cellsGenitourinary tractGU tractUnderstanding of DCsSubsets of DCsImmune defenseFemale genital mucosaInnate immune defenseGenital mucosaMaternal toleranceSex hormonesAdaptive immunityReproductive functionMacrophagesTractNumerous agentsSTIsImportant reproductive functionsCellsDivergent rolesMucosaFetusesInfectionHormone