Publications

• CRB2 Depletion Induces YAP Signaling and Disrupts Mechanosensing in Podocytes.Sun Y, Kronenberg NM, Sethi SK, Dash SN, Kovalik ME, Sempowski B, Strickland S, Raina R, Sperati CJ, Tian X, Ishibe S, Hall G, Gather MC. bioRxiv. 2024 Oct 26; 2024 Oct 26. PMID: 39484460.
• ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging.Jiang Q, Song G, He L, Li X, Jiang B, Wang Q, Wang S, Kim C, Barkestani MN, Lopez R, Fan M, Wanniarachchi K, Quaranta M, Tian X, Mani A, Gonzalez A, Goodwin JE, Sessa WC, Ishibe S, Jane-Wit D. Kidney Int. 2024 Sep; 2024 May 24. PMID: 38797325.
• Preventing MMP23-mediated cleavage of podocyte RARRES1: a novel strategy to halt chronic kidney disease progression?Medina Rangel PX, Ishibe S. Kidney Int. 2024 Jul. PMID: 38906649.
• Thrombotic Microangiopathy and Acute Tubular Injury After Diethylene Glycol Ingestion: A Kidney Biopsy Teaching Case.Malvar G, Gunasekaran D, Mehr NV, Ishibe S, Moeckel G. Kidney Med. 2024 Feb; 2023 Nov 29. PMID: 38304581.
• Profilin1 is required for prevention of mitotic catastrophe in murine and human glomerular diseases.Tian X, Pedigo CE, Li K, Ma X, Bunda P, Pell J, Lek A, Gu J, Zhang Y, Medina Rangel PX, Li W, Schwartze E, Nagata S, Lerner G, Perincheri S, Priyadarshini A, Zhao H, Lek M, Menon MC, Fu R, Ishibe S. J Clin Invest. 2023 Dec 15; 2023 Dec 15. PMID: 37847555.
• Cell Cycle and Senescence Regulation by Podocyte Histone Deacetylase 1 and 2.Medina Rangel PX, Cross E, Liu C, Pedigo CE, Tian X, Gutiérrez-Calabrés E, Nagata S, Priyadarshini A, Lerner G, Bunda P, Perincheri S, Gu J, Zhao H, Wang Y, Inoue K, Ishibe S. J Am Soc Nephrol. 2023 Mar 1; 2022 Nov 22. PMID: 36414418.
• PD-1, a New Player in Podocyte Age-Related Senescence.Medina Rangel PX, Ishibe S. Am J Kidney Dis. 2023 Mar; 2022 Nov 17. PMID: 36403888.
• Coronavirus Lung Infection Impairs Host Immunity against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction.Peng X, Kim J, Gupta G, Agaronyan K, Mankowski MC, Korde A, Takyar SS, Shin HJ, Habet V, Voth S, Audia JP, Chang D, Liu X, Wang L, Cai Y, Tian X, Ishibe S, Kang MJ, Compton S, Wilen CB, Dela Cruz CS, Sharma L. J Immunol. 2022 Oct 1; 2022 Sep 2. PMID: 36165196.
• Feeding the Kidney Researcher Pipeline through R25-NIDDK Funded Summer Undergraduate Research Fellowships: A Student Perspective.Wilson EM, Lipp SN, Brady CT, Ishibe S, Romero MF. Kidney360. 2022 Mar 31; 2021 Oct 22. PMID: 35582187.
• Podocyte Endocytosis in Regulating the Glomerular Filtration Barrier.Tian X, Bunda P, Ishibe S. Front Med (Lausanne). 2022; 2022 Feb 10. PMID: 35223901.
• Distinct Roles of Type I and Type III Interferons during a Native Murine β Coronavirus Lung Infection.Sharma L, Peng X, Qing H, Hilliard BK, Kim J, Swaminathan A, Tian J, Israni-Winger K, Zhang C, Habet V, Wang L, Gupta G, Tian X, Ma Y, Shin HJ, Kim SH, Kang MJ, Ishibe S, Young LH, Kotenko S, Compton S, Wilen CB, Wang A, Dela Cruz CS. J Virol. 2022 Jan 26; 2021 Oct 27. PMID: 34705554.
• Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes.Zhang Z, Sun Z, Fu J, Lin Q, Banu K, Chauhan K, Planoutene M, Wei C, Salem F, Yi Z, Liu R, Cravedi P, Cheng H, Hao K, O'Connell PJ, Ishibe S, Zhang W, Coca SG, Gibson IW, Colvin RB, He JC, Heeger PS, Murphy B, Menon MC. J Clin Invest. 2021 Nov 15. PMID: 34499625.
• AMPK mediates regulation of glomerular volume and podocyte survival.Banu K, Lin Q, Basgen JM, Planoutene M, Wei C, Reghuvaran AC, Tian X, Shi H, Garzon F, Garzia A, Chun N, Cumpelik A, Santeusanio AD, Zhang W, Das B, Salem F, Li L, Ishibe S, Cantley LG, Kaufman L, Lemley KV, Ni Z, He JC, Murphy B, Menon MC. JCI Insight. 2021 Oct 8; 2021 Oct 8. PMID: 34473647.
• Dynamin 1 is important for microtubule organization and stabilization in glomerular podocytes.La TM, Tachibana H, Li SA, Abe T, Seiriki S, Nagaoka H, Takashima E, Takeda T, Ogawa D, Makino SI, Asanuma K, Watanabe M, Tian X, Ishibe S, Sakane A, Sasaki T, Wada J, Takei K, Yamada H. FASEB J. 2020 Dec; 2020 Oct 17. PMID: 33070431.
• Murine Epsins Play an Integral Role in Podocyte Function.Wang Y, Pedigo CE, Inoue K, Tian X, Cross E, Ebenezer K, Li W, Wang Z, Shin JW, Schwartze E, Groener M, Ishibe S. J Am Soc Nephrol. 2020 Dec; 2020 Oct 13. PMID: 33051360.
• Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury.Tian X, Inoue K, Zhang Y, Wang Y, Sperati CJ, Pedigo CE, Zhao T, Yan M, Groener M, Moledina DG, Ebenezer K, Li W, Zhang Z, Liebermann DA, Greene L, Greer P, Parikh CR, Ishibe S. JCI Insight. 2020 Nov 19; 2020 Nov 19. PMID: 33208557.
• Identification of Podocyte Cargo Proteins by Proteomic Analysis of Clathrin-Coated Vesicles.Groener M, Wang Y, Cross E, Tian X, Ebenezer K, Baik E, Pedigo C, Schiffer M, Inoue K, Ishibe S. Kidney360. 2020 Jun 25; 2020 Apr 16. PMID: 35368594.
• Inhibition of Endocytosis of Clathrin-Mediated Angiotensin II Receptor Type 1 in Podocytes Augments Glomerular Injury.Inoue K, Tian X, Velazquez H, Soda K, Wang Z, Pedigo CE, Wang Y, Cross E, Groener M, Shin JW, Li W, Hassan H, Yamamoto K, Mundel P, Ishibe S. J Am Soc Nephrol. 2019 Dec; 2019 Sep 11. PMID: 31511362.
• The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery.Mansour SG, Zhang WR, Moledina DG, Coca SG, Jia Y, Thiessen-Philbrook H, McArthur E, Inoue K, Koyner JL, Shlipak MG, Wilson FP, Garg AX, Ishibe S, Parikh CR. Am J Kidney Dis. 2019 Jul; 2019 Apr 5. PMID: 30955944.
• Podocyte histone deacetylase activity regulates murine and human glomerular diseases.Inoue K, Gan G, Ciarleglio M, Zhang Y, Tian X, Pedigo CE, Cavanaugh C, Tate J, Wang Y, Cross E, Groener M, Chai N, Wang Z, Justice A, Zhang Z, Parikh CR, Wilson FP, Ishibe S. J Clin Invest. 2019 Mar 1; 2019 Feb 18. PMID: 30776024.
• Vinculin is required to maintain glomerular barrier integrity.Lausecker F, Tian X, Inoue K, Wang Z, Pedigo CE, Hassan H, Liu C, Zimmer M, Jinno S, Huckle AL, Hamidi H, Ross RS, Zent R, Ballestrem C, Lennon R, Ishibe S. Kidney Int. 2018 Mar; 2017 Dec 12. PMID: 29241625.
• Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development.Mathew S, Palamuttam RJ, Mernaugh G, Ramalingam H, Lu Z, Zhang MZ, Ishibe S, Critchley DR, Fässler R, Pozzi A, Sanders CR, Carroll TJ, Zent R. Development. 2017 Nov 15; 2017 Oct 9. PMID: 28993400.
• Loss of the podocyte glucocorticoid receptor exacerbates proteinuria after injury.Zhou H, Tian X, Tufro A, Moeckel G, Ishibe S, Goodwin J. Sci Rep. 2017 Aug 29; 2017 Aug 29. PMID: 28852159.
• Kidney Tubular Ablation of Ocrl/Inpp5b Phenocopies Lowe Syndrome Tubulopathy.Inoue K, Balkin DM, Liu L, Nandez R, Wu Y, Tian X, Wang T, Nussbaum R, De Camilli P, Ishibe S. J Am Soc Nephrol. 2017 May; 2016 Nov 28. PMID: 27895154.
• Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice.Beckerman P, Bi-Karchin J, Park AS, Qiu C, Dummer PD, Soomro I, Boustany-Kari CM, Pullen SS, Miner JH, Hu CA, Rohacs T, Inoue K, Ishibe S, Saleem MA, Palmer MB, Cuervo AM, Kopp JB, Susztak K. Nat Med. 2017 Apr; 2017 Feb 20. PMID: 28218918.
• New Insights into Diabetic Kidney Disease: The Potential Pathogenesis and Therapeutic Targets.Liu WJ, Reiser J, Park TS, Liu Z, Ishibe S. J Diabetes Res. 2017; 2017 Nov 8. PMID: 29250556.
• Targeting the podocyte cytoskeleton: from pathogenesis to therapy in proteinuric kidney disease.Tian X, Ishibe S. Nephrol Dial Transplant. 2016 Oct; 2016 Mar 10. PMID: 26968197.
• Essential Role of X-Box Binding Protein-1 during Endoplasmic Reticulum Stress in Podocytes.Hassan H, Tian X, Inoue K, Chai N, Liu C, Soda K, Moeckel G, Tufro A, Lee AH, Somlo S, Fedeles S, Ishibe S. J Am Soc Nephrol. 2016 Apr; 2015 Aug 24. PMID: 26303067.
• Podocyte endocytosis in the regulation of the glomerular filtration barrier.Inoue K, Ishibe S. Am J Physiol Renal Physiol. 2015 Sep 1; 2015 Jun 17. PMID: 26084928.
• The function of endocytosis in podocytes.Soda K, Ishibe S. Curr Opin Nephrol Hypertens. 2013 Jul. PMID: 23703394.
• Role of dynamin, synaptojanin, and endophilin in podocyte foot processes.Soda K, Balkin DM, Ferguson SM, Paradise S, Milosevic I, Giovedi S, Volpicelli-Daley L, Tian X, Wu Y, Ma H, Son SH, Zheng R, Moeckel G, Cremona O, Holzman LB, De Camilli P, Ishibe S. J Clin Invest. 2012 Dec; 2012 Nov 26. PMID: 23187129.
• Hepatocyte Growth Factor stimulated cell scattering requires ERK and Cdc42-dependent tight junction disassembly.Togawa A, Sfakianos J, Ishibe S, Suzuki S, Fujigaki Y, Kitagawa M, Mellman I, Cantley LG. Biochem Biophys Res Commun. 2010 Sep 17; 2010 Aug 20. PMID: 20728428.
• Inhibition of podocyte FAK protects against proteinuria and foot process effacement.Ma H, Togawa A, Soda K, Zhang J, Lee S, Ma M, Yu Z, Ardito T, Czyzyk J, Diggs L, Joly D, Hatakeyama S, Kawahara E, Holzman L, Guan JL, Ishibe S. J Am Soc Nephrol. 2010 Jul; 2010 Jun 3. PMID: 20522532.
• Deletion of the Met receptor in the collecting duct decreases renal repair following ureteral obstruction.Ma H, Saenko M, Opuko A, Togawa A, Soda K, Marlier A, Moeckel GW, Cantley LG, Ishibe S. Kidney Int. 2009 Oct; 2009 Aug 12. PMID: 19675527.
• Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology.Ishibe S, Karihaloo A, Ma H, Zhang J, Marlier A, Mitobe M, Togawa A, Schmitt R, Czyczk J, Kashgarian M, Geller DS, Thorgeirsson SS, Cantley LG. Development. 2009 Jan. PMID: 19103805.
• Epithelial-mesenchymal-epithelial cycling in kidney repair.Ishibe S, Cantley LG. Curr Opin Nephrol Hypertens. 2008 Jul. PMID: 18660674.
• Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.Shibazaki S, Yu Z, Nishio S, Tian X, Thomson RB, Mitobe M, Louvi A, Velazquez H, Ishibe S, Cantley LG, Igarashi P, Somlo S. Hum Mol Genet. 2008 Jun 1; 2008 Feb 7. PMID: 18263604.
• Cell confluence regulates hepatocyte growth factor-stimulated cell morphogenesis in a beta-catenin-dependent manner.Ishibe S, Haydu JE, Togawa A, Marlier A, Cantley LG. Mol Cell Biol. 2006 Dec; 2006 Oct 9. PMID: 17030602.
• Expression of neutrophil gelatinase-associated lipocalin regulates epithelial morphogenesis in vitro.Gwira JA, Wei F, Ishibe S, Ueland JM, Barasch J, Cantley LG. J Biol Chem. 2005 Mar 4; 2005 Jan 6. PMID: 15637066.
• Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis.Ishibe S, Joly D, Liu ZX, Cantley LG. Mol Cell. 2004 Oct 22. PMID: 15494312.
• Methods of assessment of volume status and intercompartmental fluid shifts in hemodialysis patients: implications in clinical practice.Ishibe S, Peixoto AJ. Semin Dial. 2004 Jan-Feb. PMID: 14717810.
• Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis.Ishibe S, Joly D, Zhu X, Cantley LG. Mol Cell. 2003 Nov. PMID: 14636584.
• Nephrogenic fibrosing dermopathy: an unusual skin condition associated with kidney disease.Perazella MA, Ishibe S, Perazella MA, Reilly RF. Semin Dial. 2003 May-Jun. PMID: 12753692.