Publications

2021

The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study.Moledina DG, Simonov M, Yamamoto Y, Alausa J, Arora T, Biswas A, Cantley LG, Ghazi L, Greenberg JH, Hinchcliff M, Huang C, Mansour SG, Martin M, Peixoto A, Schulz W, Subair L, Testani JM, Ugwuowo U, Young P, Wilson FP. Am J Kidney Dis. 2021 Apr; 2021 Jan 8. PMID: 33422598.
Large-Scale Characterization of Systemic Sclerosis Serum Protein Profile: Comparison to Peripheral Blood Cell Transcriptome and Correlations With Skin/Lung Fibrosis.Bellocchi C, Ying J, Goldmuntz EA, Keyes-Elstein L, Varga J, Hinchcliff ME, Lyons MA, McSweeney P, Furst DE, Nash R, Crofford LJ, Welch B, Goldin JG, Pinckney A, Mayes MD, Sullivan KM, Assassi S. Arthritis Rheumatol. 2021 Apr; 2021 Feb 28. PMID: 33131208.
A Review and Roadmap of the Skin, Lung, and Gut Microbiota in Systemic Sclerosis.Teaw S, Hinchcliff M, Cheng M. Rheumatology (Oxford). 2021 Mar 17; 2021 Mar 17. PMID: 33734316.
Electronic health record alerts for acute kidney injury: multicenter, randomized clinical trial.Wilson FP, Martin M, Yamamoto Y, Partridge C, Moreira E, Arora T, Biswas A, Feldman H, Garg AX, Greenberg JH, Hinchcliff M, Latham S, Li F, Lin H, Mansour SG, Moledina DG, Palevsky PM, Parikh CR, Simonov M, Testani J, Ugwuowo U. BMJ. 2021 Jan 18; 2021 Jan 18. PMID: 33461986.
Computer vision applied to dual-energy computed tomography images for precise calcinosis cutis quantification in patients with systemic sclerosis.Chandrasekaran AC, Fu Z, Kraniski R, Wilson FP, Teaw S, Cheng M, Wang A, Ren S, Omar IM, Hinchcliff ME. Arthritis Res Ther. 2021 Jan 6; 2021 Jan 6. PMID: 33407814.

2020

Predictive Significance of Serum Interferon Inducible Protein Score for Response to Treatment in Systemic Sclerosis Related Interstitial Lung Disease.Assassi S, Li N, Volkmann ER, Mayes MD, Rünger D, Ying J, Roth MD, Hinchcliff M, Khanna D, Frech T, Clements PJ, Furst DE, Goldin J, Bernstein EJ, Castelino FV, Domsic RT, Gordon JK, Hant FN, Shah AA, Shanmugam VK, Steen VD, Elashoff RM, Tashkin DP. Arthritis Rheumatol. 2020 Dec 21; 2020 Dec 21. PMID: 33350170.
Performance Characteristics of Pulmonary Function Tests for the Detection of Interstitial Lung Disease in Adults With Early Diffuse Cutaneous Systemic Sclerosis.Bernstein EJ, Jaafar S, Assassi S, Domsic RT, Frech TM, Gordon JK, Broderick RJ, Hant FN, Hinchcliff ME, Shah AA, Shanmugam VK, Steen VD, Khanna D. Arthritis Rheumatol. 2020 Nov; 2020 Sep 22. PMID: 32583956.
Molecular "omic" signatures in systemic sclerosis.Mehta BK, Espinoza ME, Hinchcliff M, Whitfield ML. Eur J Rheumatol. 2020 Oct; 2020 Oct 1. PMID: 33164732.
Calcinosis is associated with ischemic manifestations and increased disability in patients with systemic sclerosis.Valenzuela A, Baron M, Rodriguez-Reyna TS, Proudman S, Khanna D, Young A, Hinchcliff M, Steen V, Gordon J, Hsu V, Castelino FV, Schoenfeld S, Li S, Wu JY, Fiorentino D, Chung L. Semin Arthritis Rheum. 2020 Oct; 2020 Jun 17. PMID: 32898758.
Regulator combinations identify systemic sclerosis patients with more severe disease.Wang Y, Franks JM, Yang M, Toledo DM, Wood TA, Hinchcliff M, Whitfield ML. JCI Insight. 2020 Sep 3; 2020 Sep 3. PMID: 32721949.
Lenabasum for Skin Disease in Patients With Diffuse Cutaneous Systemic Sclerosis.Hinchcliff M. Arthritis Rheumatol. 2020 Aug; 2020 Jul 4. PMID: 32368869.
Profibrotic Activation of Human Macrophages in Systemic Sclerosis.Bhandari R, Ball MS, Martyanov V, Popovich D, Schaafsma E, Han S, ElTanbouly M, Orzechowski NM, Carns M, Arroyo E, Aren K, Hinchcliff M, Whitfield ML, Pioli PA. Arthritis Rheumatol. 2020 Jul; 2020 May 31. PMID: 32134204.
Current and Potential New Targets in Systemic Sclerosis Therapy: a New Hope.Hinchcliff M, O'Reilly S. Curr Rheumatol Rep. 2020 Jun 19; 2020 Jun 19. PMID: 32562016.
High-throughput quantitative histology in systemic sclerosis skin disease using computer vision.Correia C, Mawe S, Lofgren S, Marangoni RG, Lee J, Saber R, Aren K, Cheng M, Teaw S, Hoffmann A, Goldberg I, Cowper SE, Khatri P, Hinchcliff M, Mahoney JM. Arthritis Res Ther. 2020 Mar 14; 2020 Mar 14. PMID: 32171325.
Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile.Skaug B, Khanna D, Swindell WR, Hinchcliff ME, Frech TM, Steen VD, Hant FN, Gordon JK, Shah AA, Zhu L, Zheng WJ, Browning JL, Barron AMS, Wu M, Visvanathan S, Baum P, Franks JM, Whitfield ML, Shanmugam VK, Domsic RT, Castelino FV, Bernstein EJ, Wareing N, Lyons MA, Ying J, Charles J, Mayes MD, Assassi S. Ann Rheum Dis. 2020 Mar; 2019 Nov 25. PMID: 31767698.

2019

Myeloablation followed by autologous stem cell transplantation normalises systemic sclerosis molecular signatures.Assassi S, Wang X, Chen G, Goldmuntz E, Keyes-Elstein L, Ying J, Wallace PK, Turner J, Zheng WJ, Pascual V, Varga J, Hinchcliff ME, Bellocchi C, McSweeney P, Furst DE, Nash RA, Crofford LJ, Welch B, Pinckney A, Mayes MD, Sullivan KM. Ann Rheum Dis. 2019 Oct; 2019 Aug 7. PMID: 31391177.
Connective Tissue Disease-Associated Interstitial Lung Disease: Evaluation and Management.Antin-Ozerkis D, Hinchcliff M. Clin Chest Med. 2019 Sep. PMID: 31376896.
Towards a new classification of systemic sclerosis.Hinchcliff M, Mahoney JM. Nat Rev Rheumatol. 2019 Aug. PMID: 31217541.
Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.Reyfman PA, Walter JM, Joshi N, Anekalla KR, McQuattie-Pimentel AC, Chiu S, Fernandez R, Akbarpour M, Chen CI, Ren Z, Verma R, Abdala-Valencia H, Nam K, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Watanabe S, Williams KJN, Flozak AS, Nicholson TT, Morgan VK, Winter DR, Hinchcliff M, Hrusch CL, Guzy RD, Bonham CA, Sperling AI, Bag R, Hamanaka RB, Mutlu GM, Yeldandi AV, Marshall SA, Shilatifard A, Amaral LAN, Perlman H, Sznajder JI, Argento AC, Gillespie CT, Dematte J, Jain M, Singer BD, Ridge KM, Lam AP, Bharat A, Bhorade SM, Gottardi CJ, Budinger GRS, Misharin AV. Am J Respir Crit Care Med. 2019 Jun 15. PMID: 30554520.
Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study.Scott MKD, Quinn K, Li Q, Carroll R, Warsinske H, Vallania F, Chen S, Carns MA, Aren K, Sun J, Koloms K, Lee J, Baral J, Kropski J, Zhao H, Herzog E, Martinez FJ, Moore BB, Hinchcliff M, Denny J, Kaminski N, Herazo-Maya JD, Shah NH, Khatri P. Lancet Respir Med. 2019 Jun; 2019 Mar 29. PMID: 30935881.
Normal Values of Esophageal Distensibility and Distension-Induced Contractility Measured by Functional Luminal Imaging Probe Panometry.Carlson DA, Kou W, Lin Z, Hinchcliff M, Thakrar A, Falmagne S, Prescott J, Dorian E, Kahrilas PJ, Pandolfino JE. Clin Gastroenterol Hepatol. 2019 Mar; 2018 Aug 3. PMID: 30081222.
The importance of technical skills assessment during an airway foreign body removal course.Hinchcliff M, Kao M, Johnson K. Int J Pediatr Otorhinolaryngol. 2019 Feb; 2018 Nov 9. PMID: 30579061.
Risk Factors for Mortality and Cardiopulmonary Hospitalization in Systemic Sclerosis Patients At Risk for Pulmonary Hypertension, in the PHAROS Registry.Hsu VM, Chung L, Hummers LK, Shah A, Simms R, Bolster M, Hant FN, Silver RM, Fischer A, Hinchcliff ME, Varga J, Goldberg AZ, Derk CT, Schiopu E, Khanna D, Shapiro LS, Domsic RT, Medsger T, Mayes MD, Furst D, Csuka ME, Molitor JA, Saketkoo LA, Salazar CR, Steen VD. J Rheumatol. 2019 Feb; 2018 Oct 1. PMID: 30275260.

2018

Performance of Forced Vital Capacity and Lung Diffusion Cutpoints for Associated Radiographic Interstitial Lung Disease in Systemic Sclerosis.Showalter K, Hoffmann A, Rouleau G, Aaby D, Lee J, Richardson C, Dematte J, Agrawal R, Chang RW, Hinchcliff M. J Rheumatol. 2018 Nov; 2018 Oct 1. PMID: 30275265.
The Scleroderma Patient-Centered Intervention Network Cohort: baseline clinical features and comparison with other large scleroderma cohorts.Dougherty DH, Kwakkenbos L, Carrier ME, Salazar G, Assassi S, Baron M, Bartlett SJ, Furst DE, Gottesman K, van den Hoogen F, Malcarne VL, Mouthon L, Nielson WR, Poiraudeau S, Sauvé M, Boire G, Bruns A, Chung L, Denton C, Dunne JV, Fortin P, Frech T, Gill A, Gordon J, Herrick AL, Hinchcliff M, Hudson M, Johnson SR, Jones N, Kafaja S, Larché M, Manning J, Pope J, Spiera R, Steen V, Sutton E, Thorne C, Wilcox P, Thombs BD, Mayes MD. Rheumatology (Oxford). 2018 Sep 1. PMID: 29868924.
The novel adipokine C1q-TNF related protein 9 (CTRP9) is elevated in systemic sclerosis-associated interstitial lung disease.Korman B, Alejo R, Sudhakar D, Hinchcliff M, Agrawal R, Varga J, Marangoni RG. Clin Exp Rheumatol. 2018 Jul-Aug; 2018 Aug 28. PMID: 30183591.
Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound-Guided Synovial Biopsies in Rheumatoid Arthritis.Mandelin AM 2nd, Homan PJ, Shaffer AM, Cuda CM, Dominguez ST, Bacalao E, Carns M, Hinchcliff M, Lee J, Aren K, Thakrar A, Montgomery AB, Bridges SL Jr, Bathon JM, Atkinson JP, Fox DA, Matteson EL, Buckley CD, Pitzalis C, Parks D, Hughes LB, Geraldino-Pardilla L, Ike R, Phillips K, Wright K, Filer A, Kelly S, Ruderman EM, Morgan V, Abdala-Valencia H, Misharin AV, Budinger GS, Bartom ET, Pope RM, Perlman H, Winter DR. Arthritis Rheumatol. 2018 Jun; 2018 May 3. PMID: 29439295.
Mycophenolate Mofetil Treatment of Systemic Sclerosis Reduces Myeloid Cell Numbers and Attenuates the Inflammatory Gene Signature in Skin.Hinchcliff M, Toledo DM, Taroni JN, Wood TA, Franks JM, Ball MS, Hoffmann A, Amin SM, Tan AU, Tom K, Nesbeth Y, Lee J, Ma M, Aren K, Carns MA, Pioli PA, Whitfield ML. J Invest Dermatol. 2018 Jun; 2018 Jan 31. PMID: 29391252.
Diffuse cardiac fibrosis quantification in early systemic sclerosis by magnetic resonance imaging and correlation with skin fibrosis.Lee DC, Hinchcliff ME, Sarnari R, Stark MM, Lee J, Koloms K, Hoffmann A, Carns M, Thakrar A, Aren K, Varga J, Aquino A, Carr JC, Benefield BC, Shah SJ. J Scleroderma Relat Disord. 2018 Jun; 2018 Apr 12. PMID: 29808171.
Abnormal esophageal acid exposure on high-dose proton pump inhibitor therapy is common in systemic sclerosis patients.Stern EK, Carlson DA, Falmagne S, Hoffmann AD, Carns M, Pandolfino JE, Hinchcliff M, Brenner DM. Neurogastroenterol Motil. 2018 Feb; 2017 Nov 6. PMID: 29110377.

2017

Brief Report: Association of Elevated Adipsin Levels With Pulmonary Arterial Hypertension in Systemic Sclerosis.Korman BD, Marangoni RG, Hinchcliff M, Shah SJ, Carns M, Hoffmann A, Ramsey-Goldman R, Varga J. Arthritis Rheumatol. 2017 Oct. PMID: 28651038.
Utility of B-type natriuretic peptides in the assessment of patients with systemic sclerosis-associated pulmonary hypertension in the PHAROS registry.Chung L, Fairchild RM, Furst DE, Li S, Alkassab F, Bolster MB, Csuka ME, Derk CT, Domsic RT, Fischer A, Frech TM, Gomberg-Maitland M, Gordon JK, Hinchcliff M, Hsu V, Hummers LK, Khanna D, Medsger TAJ, Molitor JA, Preston IR, Schiopu E, Shapiro L, Hant F, Silver R, Simms R, Varga J, Steen VD, Zamanian RT. Clin Exp Rheumatol. 2017 Sep-Oct; 2016 Nov 10. PMID: 27908301.
Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H. J Exp Med. 2017 Aug 7; 2017 Jul 10. PMID: 28694385.
Reliability and Validity of the Tender and Swollen Joint Counts and the Modified Rodnan Skin Score in Early Diffuse Cutaneous Systemic Sclerosis: Analysis from the Prospective Registry of Early Systemic Sclerosis Cohort.Gordon JK, Girish G, Berrocal VJ, Zhang M, Hatzis C, Assassi S, Bernstein EJ, Domsic RT, Hant FN, Hinchcliff M, Schiopu E, Steen VD, Frech TM, Khanna D. J Rheumatol. 2017 Jun; 2017 Mar 15. PMID: 28298560.
A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis.Taroni JN, Greene CS, Martyanov V, Wood TA, Christmann RB, Farber HW, Lafyatis RA, Denton CP, Hinchcliff ME, Pioli PA, Mahoney JM, Whitfield ML. Genome Med. 2017 Mar 23; 2017 Mar 23. PMID: 28330499.

2016

Integrated, multicohort analysis of systemic sclerosis identifies robust transcriptional signature of disease severity.Lofgren S, Hinchcliff M, Carns M, Wood T, Aren K, Arroyo E, Cheung P, Kuo A, Valenzuela A, Haemel A, Wolters PJ, Gordon J, Spiera R, Assassi S, Boin F, Chung L, Fiorentino D, Utz PJ, Whitfield ML, Khatri P. JCI Insight. 2016 Dec 22; 2016 Dec 22. PMID: 28018971.
Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: A Scleroderma Clinical Trials Consortium study.Valenzuela A, Baron M, Herrick AL, Proudman S, Stevens W, Rodriguez-Reyna TS, Vacca A, Medsger TA Jr, Hinchcliff M, Hsu V, Wu JY, Fiorentino D, Chung L. Semin Arthritis Rheum. 2016 Dec; 2016 Jun 2. PMID: 27371996.
Loss of Peristaltic Reserve, Determined by Multiple Rapid Swallows, Is the Most Frequent Esophageal Motility Abnormality in Patients With Systemic Sclerosis.Carlson DA, Crowell MD, Kimmel JN, Patel A, Gyawali CP, Hinchcliff M, Griffing WL, Pandolfino JE, Vela MF. Clin Gastroenterol Hepatol. 2016 Oct; 2016 Apr 5. PMID: 27062902.
Fulminant capillary leak syndrome in a patient with systemic sclerosis treated with imatinib mesylate.Hinchcliff ME, Lomasney J, Johnson JA, Varga J. Rheumatology (Oxford). 2016 Oct; 2016 Jun 23. PMID: 27338086.
Comment on "Esophageal dilatation and interstitial lung disease in systemic sclerosis: A cross-sectional study".Hoffmann A, Lee J, Ma M, Agrawal R, Chang RW, Richardson C, Hinchcliff M, Showalter K. Semin Arthritis Rheum. 2016 Oct; 2016 May 6. PMID: 27312382.
Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial.Tashkin DP, Roth MD, Clements PJ, Furst DE, Khanna D, Kleerup EC, Goldin J, Arriola E, Volkmann ER, Kafaja S, Silver R, Steen V, Strange C, Wise R, Wigley F, Mayes M, Riley DJ, Hussain S, Assassi S, Hsu VM, Patel B, Phillips K, Martinez F, Golden J, Connolly MK, Varga J, Dematte J, Hinchcliff ME, Fischer A, Swigris J, Meehan R, Theodore A, Simms R, Volkov S, Schraufnagel DE, Scholand MB, Frech T, Molitor JA, Highland K, Read CA, Fritzler MJ, Kim GHJ, Tseng CH, Elashoff RM. Lancet Respir Med. 2016 Sep; 2016 Jul 25. PMID: 27469583.
The association between systemic sclerosis disease manifestations and esophageal high-resolution manometry parameters.Kimmel JN, Carlson DA, Hinchcliff M, Carns MA, Aren KA, Lee J, Pandolfino JE. Neurogastroenterol Motil. 2016 Aug; 2016 Feb 27. PMID: 26921101.
Esophageal dilatation and interstitial lung disease in systemic sclerosis: A cross-sectional study.Richardson C, Agrawal R, Lee J, Almagor O, Nelson R, Varga J, Cuttica MJ, Dematte JD, Chang RW, Hinchcliff ME. Semin Arthritis Rheum. 2016 Aug; 2016 Feb 26. PMID: 27033049.
Tenascin-C drives persistence of organ fibrosis.Bhattacharyya S, Wang W, Morales-Nebreda L, Feng G, Wu M, Zhou X, Lafyatis R, Lee J, Hinchcliff M, Feghali-Bostwick C, Lakota K, Budinger GR, Raparia K, Tamaki Z, Varga J. Nat Commun. 2016 Jun 3; 2016 Jun 3. PMID: 27256716.
The relationship between skin symptoms and the scleroderma modification of the health assessment questionnaire, the modified Rodnan skin score, and skin pathology in patients with systemic sclerosis.Ziemek J, Man A, Hinchcliff M, Varga J, Simms RW, Lafyatis R. Rheumatology (Oxford). 2016 May; 2016 Feb 15. PMID: 26880832.
Genetic susceptibility loci of idiopathic interstitial pneumonia do not represent risk for systemic sclerosis: a case control study in Caucasian patients.Wu M, Assassi S, Salazar GA, Pedroza C, Gorlova OY, Chen WV, Charles J, Taing ML, Liao K, Wigley FM, Hummers LK, Shah AA, Hinchcliff M, Khanna D, Schiopu E, Phillips K, Furst DE, Steen V, Baron M, Hudson M, Zhou X, Pope J, Jones N, Docherty P, Khalidi NA, Robinson D, Simms RW, Silver RM, Frech TM, Fessler BJ, Fritzler MJ, Molitor JA, Segal BM, Movahedian M, Martín J, Varga J, Mayes MD. Arthritis Res Ther. 2016 Jan 20; 2016 Jan 20. PMID: 26792595.

2015

Survival in systemic sclerosis-pulmonary arterial hypertension by serum autoantibody status in the Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma (PHAROS) Registry.Hinchcliff M, Khanna S, Hsu VM, Lee J, Almagor O, Chang RW, Steen V, Chung L. Semin Arthritis Rheum. 2015 Dec; 2015 Jun 19. PMID: 26210782.
Molecular characterization of systemic sclerosis esophageal pathology identifies inflammatory and proliferative signatures.Taroni JN, Martyanov V, Huang CC, Mahoney JM, Hirano I, Shetuni B, Yang GY, Brenner D, Jung B, Wood TA, Bhattacharyya S, Almagor O, Lee J, Sirajuddin A, Varga J, Chang RW, Whitfield ML, Hinchcliff M. Arthritis Res Ther. 2015 Jul 29; 2015 Jul 29. PMID: 26220546.
Cardiac metabolomics and autopsy in a patient with early diffuse systemic sclerosis presenting with dyspnea: a case report.Frech TM, Revelo MP, Ryan JJ, Shah AA, Gordon J, Domsic R, Hant F, Assassi S, Shanmugam VK, Hinchcliff M, Steen V, Khanna D, Bernstein EJ, Cox J, Luem N, Drakos S. J Med Case Rep. 2015 Jun 10; 2015 Jun 10. PMID: 26055398.
Antinuclear antibody-negative systemic sclerosis.Salazar GA, Assassi S, Wigley F, Hummers L, Varga J, Hinchcliff M, Khanna D, Schiopu E, Phillips K, Furst DE, Steen V, Baron M, Hudson M, Taillefer SS, Pope J, Jones N, Docherty P, Khalidi NA, Robinson D, Simms RW, Silver RM, Frech TM, Fessler BJ, Molitor JA, Fritzler MJ, Segal BM, Al-Kassab F, Perry M, Yang J, Zamanian S, Reveille JD, Arnett FC, Pedroza C, Mayes MD. Semin Arthritis Rheum. 2015 Jun; 2014 Nov 28. PMID: 25578738.
A candidate gene study reveals association between a variant of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) gene and systemic sclerosis.Marangoni RG, Korman BD, Allanore Y, Dieude P, Armstrong LL, Rzhetskaya M, Hinchcliff M, Carns M, Podlusky S, Shah SJ, Ruiz B, Hachulla E, Tiev K, Cracowski JL, Varga J, Hayes MG. Arthritis Res Ther. 2015 May 19; 2015 May 19. PMID: 25986483.
The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling.Wei J, Ghosh AK, Chu H, Fang F, Hinchcliff ME, Wang J, Marangoni RG, Varga J. Arthritis Rheumatol. 2015 May. PMID: 25707573.
Serum amyloid A is a marker for pulmonary involvement in systemic sclerosis.Lakota K, Carns M, Podlusky S, Mrak-Poljsak K, Hinchcliff M, Lee J, Tomsic M, Sodin-Semrl S, Varga J. PLoS One. 2015; 2015 Jan 28. PMID: 25629975.
Experimentally-derived fibroblast gene signatures identify molecular pathways associated with distinct subsets of systemic sclerosis patients in three independent cohorts.Johnson ME, Mahoney JM, Taroni J, Sargent JL, Marmarelis E, Wu MR, Varga J, Hinchcliff ME, Whitfield ML. PLoS One. 2015; 2015 Jan 21. PMID: 25607805.
Systems level analysis of systemic sclerosis shows a network of immune and profibrotic pathways connected with genetic polymorphisms.Mahoney JM, Taroni J, Martyanov V, Wood TA, Greene CS, Pioli PA, Hinchcliff ME, Whitfield ML. PLoS Comput Biol. 2015 Jan; 2015 Jan 8. PMID: 25569146.
Advances in the evaluation and management of esophageal disease of systemic sclerosis.Carlson DA, Hinchcliff M, Pandolfino JE. Curr Rheumatol Rep. 2015 Jan. PMID: 25475597.
Longitudinal evaluation of PROMIS-29 and FACIT-dyspnea short forms in systemic sclerosis.Hinchcliff ME, Beaumont JL, Carns MA, Podlusky S, Thavarajah K, Varga J, Cella D, Chang RW. J Rheumatol. 2015 Jan; 2014 Nov 1. PMID: 25362656.

2014

Pulmonary hypertension and interstitial lung disease within PHAROS: impact of extent of fibrosis and pulmonary physiology on cardiac haemodynamic parameters.Fischer A, Swigris JJ, Bolster MB, Chung L, Csuka ME, Domsic R, Frech T, Hinchcliff M, Hsu V, Hummers LK, Gomberg-Maitland M, Mathai SC, Simms R, Steen VD. Clin Exp Rheumatol. 2014 Nov-Dec; 2014 Nov 4. PMID: 25372796.
Development of pulmonary hypertension in a high-risk population with systemic sclerosis in the Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma (PHAROS) cohort study.Hsu VM, Chung L, Hummers LK, Wigley F, Simms R, Bolster M, Silver R, Fischer A, Hinchcliff ME, Varga J, Goldberg AZ, Derk CT, Schiopu E, Khanna D, Shapiro LS, Domsic RT, Medsger T, Mayes MD, Furst D, Csuka ME, Molitor JA, Alkassab F, Steen VD. Semin Arthritis Rheum. 2014 Aug; 2014 Mar 5. PMID: 24709277.
FibronectinEDA promotes chronic cutaneous fibrosis through Toll-like receptor signaling.Bhattacharyya S, Tamaki Z, Wang W, Hinchcliff M, Hoover P, Getsios S, White ES, Varga J. Sci Transl Med. 2014 Apr 16. PMID: 24739758.
Connective tissue diseases: systemic sclerosis: beyond limited and diffuse subsets?Varga J, Hinchcliff M. Nat Rev Rheumatol. 2014 Apr; 2014 Feb 18. PMID: 24535544.
Survival and predictors of mortality in systemic sclerosis-associated pulmonary arterial hypertension: outcomes from the pulmonary hypertension assessment and recognition of outcomes in scleroderma registry.Chung L, Domsic RT, Lingala B, Alkassab F, Bolster M, Csuka ME, Derk C, Fischer A, Frech T, Furst DE, Gomberg-Maitland M, Hinchcliff M, Hsu V, Hummers LK, Khanna D, Medsger TA Jr, Molitor JA, Preston IR, Schiopu E, Shapiro L, Silver R, Simms R, Varga J, Gordon JK, Steen VD. Arthritis Care Res (Hoboken). 2014 Mar. PMID: 23983198.
A synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-γ-independent suppression of fibrotic responses.Wei J, Zhu H, Komura K, Lord G, Tomcik M, Wang W, Doniparthi S, Tamaki Z, Hinchcliff M, Distler JH, Varga J. Ann Rheum Dis. 2014 Feb; 2013 Mar 20. PMID: 23515440.
Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis.Mayes MD, Bossini-Castillo L, Gorlova O, Martin JE, Zhou X, Chen WV, Assassi S, Ying J, Tan FK, Arnett FC, Reveille JD, Guerra S, Teruel M, Carmona FD, Gregersen PK, Lee AT, López-Isac E, Ochoa E, Carreira P, Simeón CP, Castellví I, González-Gay MÁ, Zhernakova A, Padyukov L, Alarcón-Riquelme M, Wijmenga C, Brown M, Beretta L, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Distler JH, Voskuyl AE, Schuerwegh AJ, Hesselstrand R, Nordin A, Airó P, Lunardi C, Shiels P, van Laar JM, Herrick A, Worthington J, Denton C, Wigley FM, Hummers LK, Varga J, Hinchcliff ME, Baron M, Hudson M, Pope JE, Furst DE, Khanna D, Phillips K, Schiopu E, Segal BM, Molitor JA, Silver RM, Steen VD, Simms RW, Lafyatis RA, Fessler BJ, Frech TM, Alkassab F, Docherty P, Kaminska E, Khalidi N, Jones HN, Markland J, Robinson D, Broen J, Radstake TR, Fonseca C, Koeleman BP, Martin J. Am J Hum Genet. 2014 Jan 2. PMID: 24387989.

2013

Early growth response 3 (Egr-3) is induced by transforming growth factor-β and regulates fibrogenic responses.Fang F, Shangguan AJ, Kelly K, Wei J, Gruner K, Ye B, Wang W, Bhattacharyya S, Hinchcliff ME, Tourtellotte WG, Varga J. Am J Pathol. 2013 Oct; 2013 Jul 30. PMID: 23906810.
Molecular signatures in skin associated with clinical improvement during mycophenolate treatment in systemic sclerosis.Hinchcliff M, Huang CC, Wood TA, Matthew Mahoney J, Martyanov V, Bhattacharyya S, Tamaki Z, Lee J, Carns M, Podlusky S, Sirajuddin A, Shah SJ, Chang RW, Lafyatis R, Varga J, Whitfield ML. J Invest Dermatol. 2013 Aug; 2013 Mar 14. PMID: 23677167.
Treatment of early diffuse systemic sclerosis skin disease.Frech TM, Shanmugam VK, Shah AA, Assassi S, Gordon JK, Hant FN, Hinchcliff ME, Steen V, Khanna D, Kayser C, Domsic RT. Clin Exp Rheumatol. 2013 Mar-Apr; 2013 Jul 23. PMID: 23910619.

2012

The pulmonary fibrosis-associated MUC5B promoter polymorphism does not influence the development of interstitial pneumonia in systemic sclerosis.Peljto AL, Steele MP, Fingerlin TE, Hinchcliff ME, Murphy E, Podlusky S, Carns M, Schwarz M, Varga J, Schwartz DA. Chest. 2012 Dec. PMID: 22576636.
Text data extraction for a prospective, research-focused data mart: implementation and validation.Hinchcliff M, Just E, Podlusky S, Varga J, Chang RW, Kibbe WA. BMC Med Inform Decis Mak. 2012 Sep 13; 2012 Sep 13. PMID: 22970696.
Baseline characteristics and follow-up in patients with normal haemodynamics versus borderline mean pulmonary arterial pressure in systemic sclerosis: results from the PHAROS registry.Bae S, Saggar R, Bolster MB, Chung L, Csuka ME, Derk C, Domsic R, Fischer A, Frech T, Goldberg A, Hinchcliff M, Hsu V, Hummers L, Schiopu E, Mayes MD, McLaughlin V, Molitor J, Naz N, Furst DE, Maranian P, Steen V, Khanna D. Ann Rheum Dis. 2012 Aug; 2012 Feb 2. PMID: 22307943.
Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells.Wei J, Fang F, Lam AP, Sargent JL, Hamburg E, Hinchcliff ME, Gottardi CJ, Atit R, Whitfield ML, Varga J. Arthritis Rheum. 2012 Aug. PMID: 22328118.
Fibrosis in systemic sclerosis: common and unique pathobiology.Bhattacharyya S, Wei J, Tourtellotte WG, Hinchcliff M, Gottardi CG, Varga J. Fibrogenesis Tissue Repair. 2012; 2012 Jun 6. PMID: 23259815.
Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker?Lakota K, Wei J, Carns M, Hinchcliff M, Lee J, Whitfield ML, Sodin-Semrl S, Varga J. Arthritis Res Ther. 2012 May 1; 2012 May 1. PMID: 22548780.
Imatinib mesylate causes genome-wide transcriptional changes in systemic sclerosis fibroblasts in vitro.Hinchcliff M, Huang CC, Ishida W, Fang F, Lee J, Jafari N, Wilkes M, Bhattacharyya S, Leof E, Varga J. Clin Exp Rheumatol. 2012 Mar-Apr; 2012 May 29. PMID: 22691216.
Prevalence, prognosis, and factors associated with left ventricular diastolic dysfunction in systemic sclerosis.Hinchcliff M, Desai CS, Varga J, Shah SJ. Clin Exp Rheumatol. 2012 Mar-Apr; 2012 May 29. PMID: 22338601.

2011

Evidence for intranasal antinuclear autoantibodies in patients with chronic rhinosinusitis with nasal polyps.Tan BK, Li QZ, Suh L, Kato A, Conley DB, Chandra RK, Zhou J, Norton J, Carter R, Hinchcliff M, Harris K, Peters A, Grammer LC, Kern RC, Mohan C, Schleimer RP. J Allergy Clin Immunol. 2011 Dec; 2011 Oct 13. PMID: 21996343.
Validity of two new patient-reported outcome measures in systemic sclerosis: Patient-Reported Outcomes Measurement Information System 29-item Health Profile and Functional Assessment of Chronic Illness Therapy-Dyspnea short form.Hinchcliff M, Beaumont JL, Thavarajah K, Varga J, Chung A, Podlusky S, Carns M, Chang RW, Cella D. Arthritis Care Res (Hoboken). 2011 Nov. PMID: 22034123.
Post-epidemic eosinophilia-myalgia syndrome associated with L-tryptophan.Allen JA, Peterson A, Sufit R, Hinchcliff ME, Mahoney JM, Wood TA, Miller FW, Whitfield ML, Varga J. Arthritis Rheum. 2011 Nov. PMID: 21702023.
Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma (PHAROS): baseline characteristics and description of study population.Hinchcliff M, Fischer A, Schiopu E, Steen VD. J Rheumatol. 2011 Oct; 2011 Aug 15. PMID: 21844142.
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.Gorlova O, Martin JE, Rueda B, Koeleman BP, Ying J, Teruel M, Diaz-Gallo LM, Broen JC, Vonk MC, Simeon CP, Alizadeh BZ, Coenen MJ, Voskuyl AE, Schuerwegh AJ, van Riel PL, Vanthuyne M, van 't Slot R, Italiaander A, Ophoff RA, Hunzelmann N, Fonollosa V, Ortego-Centeno N, González-Gay MA, García-Hernández FJ, González-Escribano MF, Airo P, van Laar J, Worthington J, Hesselstrand R, Smith V, de Keyser F, Houssiau F, Chee MM, Madhok R, Shiels PG, Westhovens R, Kreuter A, de Baere E, Witte T, Padyukov L, Nordin A, Scorza R, Lunardi C, Lie BA, Hoffmann-Vold AM, Palm O, García de la Peña P, Carreira P, Varga J, Hinchcliff M, Lee AT, Gourh P, Amos CI, Wigley FM, Hummers LK, Nelson JL, Riemekasten G, Herrick A, Beretta L, Fonseca C, Denton CP, Gregersen PK, Agarwal S, Assassi S, Tan FK, Arnett FC, Radstake TR, Mayes MD, Martin J. PLoS Genet. 2011 Jul; 2011 Jul 14. PMID: 21779181.
Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma?Wei J, Melichian D, Komura K, Hinchcliff M, Lam AP, Lafyatis R, Gottardi CJ, MacDougald OA, Varga J. Arthritis Rheum. 2011 Jun. PMID: 21370225.

2010

Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.Radstake TR, Gorlova O, Rueda B, Martin JE, Alizadeh BZ, Palomino-Morales R, Coenen MJ, Vonk MC, Voskuyl AE, Schuerwegh AJ, Broen JC, van Riel PL, van 't Slot R, Italiaander A, Ophoff RA, Riemekasten G, Hunzelmann N, Simeon CP, Ortego-Centeno N, González-Gay MA, González-Escribano MF, Airo P, van Laar J, Herrick A, Worthington J, Hesselstrand R, Smith V, de Keyser F, Houssiau F, Chee MM, Madhok R, Shiels P, Westhovens R, Kreuter A, Kiener H, de Baere E, Witte T, Padykov L, Klareskog L, Beretta L, Scorza R, Lie BA, Hoffmann-Vold AM, Carreira P, Varga J, Hinchcliff M, Gregersen PK, Lee AT, Ying J, Han Y, Weng SF, Amos CI, Wigley FM, Hummers L, Nelson JL, Agarwal SK, Assassi S, Gourh P, Tan FK, Koeleman BP, Arnett FC, Martin J, Mayes MD. Nat Genet. 2010 May; 2010 Apr 11. PMID: 20383147.

2009

A non-Smad mechanism of fibroblast activation by transforming growth factor-beta via c-Abl and Egr-1: selective modulation by imatinib mesylate.Bhattacharyya S, Ishida W, Wu M, Wilkes M, Mori Y, Hinchcliff M, Leof E, Varga J. Oncogene. 2009 Mar 12; 2009 Jan 19. PMID: 19151753.

2008

Systemic sclerosis/scleroderma: a treatable multisystem disease.Hinchcliff M, Varga J. Am Fam Physician. 2008 Oct 15. PMID: 18953973.
Connective tissue growth factor/CCN2-null mouse embryonic fibroblasts retain intact transforming growth factor-beta responsiveness.Mori Y, Hinchcliff M, Wu M, Warner-Blankenship M, M Lyons K, Varga J. Exp Cell Res. 2008 Mar 10; 2007 Dec 23. PMID: 18201696.

2007

Novel paradigm for treating vasculopathy in systemic sclerosis: vascular progenitor cells and statins.Hinchcliff M, Varga J. Curr Rheumatol Rep. 2007 Apr. PMID: 17437659.
Obliterative vasculopathy in systemic sclerosis: endothelial precursor cells as novel targets for therapy.Hinchcliff M, Varga J. Expert Rev Clin Immunol. 2007 Jan. PMID: 20476946.
Severe reversible left ventricular dysfunction associated with multiple cardiac myxomata.Kuźniar TJ, Hinchcliff M, Zunamon A, Balagani R, Enzler M, Mandzij R. Wiad Lek. 2007. PMID: 17966897.