Publications

Neural network analysis as a novel skin outcome in a trial of belumosudil in patients with systemic sclerosis.Gunes I, Bernstein EJ, Cowper SE, Panse G, Pradhan N, Camacho LD, Page N, Bundschuh E, Williams A, Carns M, Aren K, Fantus S, Volkmann ER, Bukiri H, Correia C, Kolachalama VB, Wilson FP, Mawe S, Mahoney JM, Hinchcliff M. Arthritis Res Ther. 2025 Apr 11; 2025 Apr 11. PMID: 40217251.
Gastroesophageal Intussusception Treated With Combined Transoral Incisionless Fundoplication in a Patient With Systemic Sclerosis.Memon A, Dugan N, Muniraj T, Hinchcliff ME, Masoud A. ACG Case Rep J. 2025 Apr; 2025 Apr 5. PMID: 40196291.
Publisher Correction: An international perspective on the future of systemic sclerosis research.Abraham DJ, Black CM, Denton CP, Distler JHW, Domsic R, Feghali-Bostwick C, Gourh P, Hinchcliff M, Kolling F 4th, Kuwana M, Lafyatis R, Landegren U, Mahoney JM, Martin J, Matucci-Cerinic M, McMahan ZH, Mora AL, Mouthon L, Rabinovitch M, Rojas M, Rubin K, Trojanowska M, Varga J, Whitfield ML, Gabrielli A, Krieg T. Nat Rev Rheumatol. 2025 Apr. PMID: 40032952.
Serum type I interferon score as a disease activity biomarker in patients with diffuse cutaneous systemic sclerosis: a retrospective cohort study.Hinchcliff M, Khanna D, De Lorenzis E, Di Donato S, Carriero A, Ross RL, Huang S, Aren KA, Bernstein EJ, Carns M, Castelino FV, Domsic RT, Frech TM, Gordon JK, Hant FN, Shah AA, Shanmugam VK, Steen VD, Assassi S, Del Galdo F. Lancet Rheumatol. 2025 Mar 31; 2025 Mar 31. PMID: 40179922.
An international perspective on the future of systemic sclerosis research.Abraham DJ, Black CM, Denton CP, Distler JHW, Domsic R, Feghali-Bostwick C, Gourh P, Hinchcliff M, Kolling F 4th, Kuwana M, Lafyatis R, Landegren U, Mahoney JM, Martin J, Matucci-Cerinic M, McMahan ZH, Mora AL, Mouthon L, Rabinovitch M, Rojas M, Rubin K, Trojanowska M, Varga J, Whitfield ML, Gabrielli A, Krieg T. Nat Rev Rheumatol. 2025 Mar; 2025 Feb 14. PMID: 39953141.
Acute Systemic Sclerosis-Associated Cardiomyopathy That Improved With Glucocorticoids and Cyclophosphamide.Gustafson AA, Trinh KV, Lomasney JW, Shah SJ, Hinchcliff ME. JACC Case Rep. 2025 Feb 19. PMID: 39972702.
A Nerve-Fibroblast Axis in Mammalian Lung Fibrosis.Ishikawa G, Peng X, Ghincea A, McGovern J, Zielonka J, Jeevanandam A, Shao S, Woo S, Okuno D, Yu S, Lee CJ, Liu A, Saber T, Hu B, Sun Y, Gao R, Al Jumaily K, Homer R, Hinchcliff M, Feghali-Bostwick C, Sumida TS, Sauler M, Gomez JL, Sun H, Ryu C, Herzog EL. bioRxiv. 2025 Feb 11; 2025 Feb 11. PMID: 39314391.
Atgl-Dependent Adipocyte Lipolysis Promotes Lipodystrophy and Restrains Fibrogenic Responses during Skin Fibrosis.Caves E, Jussila A, Forni MF, Benvie A, Lei V, King D, Edelman H, Hamdan M, Odell ID, Hinchcliff M, Atit R, Horsley V. J Invest Dermatol. 2025 Jan 28; 2025 Jan 28. PMID: 39884454.
Perioral hyaluronidase injection for the treatment of microstomia in systemic sclerosis patients: A retrospective cohort study.Elgash M, Kim SR, Swallow M, Hinchcliff M, Suozzi K. J Am Acad Dermatol. 2025 Jan; 2024 Sep 21. PMID: 39307355.
Systemic sclerosis: beyond skin and lung involvement.Hinchcliff M. Curr Opin Rheumatol. 2024 Nov 1; 2024 Oct 3. PMID: 39584403.
Gastrointestinal disease in systemic sclerosis: the neglected organ system?McMahan Z, Pandolfino J, Perlman H, Del Galdo F, Hinchcliff M. Curr Opin Rheumatol. 2024 Nov 1; 2024 Aug 28. PMID: 39193877.
Neural network analysis as a novel skin outcome in a trial of belumosudil in patients with systemic sclerosis.Gunes I, Bernstein E, Cowper SE, Panse G, Pradhan N, Camacho LD, Page N, Bundschuh E, Williams A, Carns M, Aren K, Fantus S, Volkmann ER, Bukiri H, Correia C, Wang R, Kolachalama V, Wilson FP, Mawe S, Mahoney JM, Hinchcliff M. Res Sq. 2024 Oct 15; 2024 Oct 15. PMID: 39483897.
cGAS Expression is Enhanced in Systemic Sclerosis Associated Interstitial Lung Disease and Stimulates Inflammatory Myofibroblast Activation.Yu S, Hu B, Sun Y, Peng XY, Lee CJ, Woo S, McGovern J, Zielonka J, Saber T, Ghincea A, Gandhi S, Walia A, Pivarnik T, Ishikawa G, Shuai S, Sun H, Gunes BI, Kujawski S, Perez S, Odell W, Hinchcliff M, Varga J, Bostwick CF, Sauler M, Gomez JL, Ryu C, Herzog EL. medRxiv. 2024 Aug 8; 2024 Aug 8. PMID: 39211872.
2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Treatment of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases.Johnson SR, Bernstein EJ, Bolster MB, Chung JH, Danoff SK, George MD, Khanna D, Guyatt G, Mirza RD, Aggarwal R, Allen A Jr, Assassi S, Buckley L, Chami HA, Corwin DS, Dellaripa PF, Domsic RT, Doyle TJ, Falardeau CM, Frech TM, Gibbons FK, Hinchcliff M, Johnson C, Kanne JP, Kim JS, Lim SY, Matson S, McMahan ZH, Merck SJ, Nesbitt K, Scholand MB, Shapiro L, Sharkey CD, Summer R, Varga J, Warrier A, Agarwal SK, Antin-Ozerkis D, Bemiss B, Chowdhary V, Dematte D'Amico JE, Hallowell R, Hinze AM, Injean PA, Jiwrajka N, Joerns EK, Lee JS, Makol A, McDermott GC, Natalini JG, Oldham JM, Saygin D, Lakin KS, Singh N, Solomon JJ, Sparks JA, Turgunbaev M, Vaseer S, Turner A, Uhl S, Ivlev I. Arthritis Rheumatol. 2024 Aug; 2024 Jul 8. PMID: 38978310.
2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Treatment of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases.Johnson SR, Bernstein EJ, Bolster MB, Chung JH, Danoff SK, George MD, Khanna D, Guyatt G, Mirza RD, Aggarwal R, Allen A Jr, Assassi S, Buckley L, Chami HA, Corwin DS, Dellaripa PF, Domsic RT, Doyle TJ, Falardeau CM, Frech TM, Gibbons FK, Hinchcliff M, Johnson C, Kanne JP, Kim JS, Lim SY, Matson S, McMahan ZH, Merck SJ, Nesbitt K, Scholand MB, Shapiro L, Sharkey CD, Summer R, Varga J, Warrier A, Agarwal SK, Antin-Ozerkis D, Bemiss B, Chowdhary V, Dematte D'Amico JE, Hallowell R, Hinze AM, Injean PA, Jiwrajka N, Joerns EK, Lee JS, Makol A, McDermott GC, Natalini JG, Oldham JM, Saygin D, Lakin KS, Singh N, Solomon JJ, Sparks JA, Turgunbaev M, Vaseer S, Turner A, Uhl S, Ivlev I. Arthritis Care Res (Hoboken). 2024 Aug; 2024 Jul 8. PMID: 38973731.
2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Screening and Monitoring of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases.Johnson SR, Bernstein EJ, Bolster MB, Chung JH, Danoff SK, George MD, Khanna D, Guyatt G, Mirza RD, Aggarwal R, Allen A Jr, Assassi S, Buckley L, Chami HA, Corwin DS, Dellaripa PF, Domsic RT, Doyle TJ, Falardeau CM, Frech TM, Gibbons FK, Hinchcliff M, Johnson C, Kanne JP, Kim JS, Lim SY, Matson S, McMahan ZH, Merck SJ, Nesbitt K, Scholand MB, Shapiro L, Sharkey CD, Summer R, Varga J, Warrier A, Agarwal SK, Antin-Ozerkis D, Bemiss B, Chowdhary V, Dematte D'Amico JE, Hallowell R, Hinze AM, Injean PA, Jiwrajka N, Joerns EK, Lee JS, Makol A, McDermott GC, Natalini JG, Oldham JM, Saygin D, Lakin KS, Singh N, Solomon JJ, Sparks JA, Turgunbaev M, Vaseer S, Turner A, Uhl S, Ivlev I. Arthritis Care Res (Hoboken). 2024 Aug; 2024 Jul 8. PMID: 38973729.
2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Screening and Monitoring of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases.Johnson SR, Bernstein EJ, Bolster MB, Chung JH, Danoff SK, George MD, Khanna D, Guyatt G, Mirza RD, Aggarwal R, Allen A Jr, Assassi S, Buckley L, Chami HA, Corwin DS, Dellaripa PF, Domsic RT, Doyle TJ, Falardeau CM, Frech TM, Gibbons FK, Hinchcliff M, Johnson C, Kanne JP, Kim JS, Lim SY, Matson S, McMahan ZH, Merck SJ, Nesbitt K, Scholand MB, Shapiro L, Sharkey CD, Summer R, Varga J, Warrier A, Agarwal SK, Antin-Ozerkis D, Bemiss B, Chowdhary V, Dematte D'Amico JE, Hallowell R, Hinze AM, Injean PA, Jiwrajka N, Joerns EK, Lee JS, Makol A, McDermott GC, Natalini JG, Oldham JM, Saygin D, Lakin KS, Singh N, Solomon JJ, Sparks JA, Turgunbaev M, Vaseer S, Turner A, Uhl S, Ivlev I. Arthritis Rheumatol. 2024 Aug; 2024 Jul 8. PMID: 38973714.
Hyaluronic acid filler for lip augmentation in patients with systemic sclerosis: A prospective cohort study.Swallow M, Elgash M, Kim SR, Hinchcliff M, Suozzi K. JAAD Case Rep. 2024 Jul; 2024 May 16. PMID: 38952859.
Gene expression meta-analysis reveals aging and cellular senescence signatures in scleroderma-associated interstitial lung disease.Yang MM, Lee S, Neely J, Hinchcliff M, Wolters PJ, Sirota M. Front Immunol. 2024; 2024 Jan 25. PMID: 38348044.
Gene Expression Meta-Analysis Reveals Aging and Cellular Senescence Signatures in Scleroderma-associated Interstitial Lung Disease.Yang MM, Lee S, Neely J, Hinchcliff M, Wolters PJ, Sirota M. bioRxiv. 2023 Nov 7; 2023 Nov 7. PMID: 37986995.
IL-6 trans-signaling in a humanized mouse model of scleroderma.Odell ID, Agrawal K, Sefik E, Odell AV, Caves E, Kirkiles-Smith NC, Horsley V, Hinchcliff M, Pober JS, Kluger Y, Flavell RA. Proc Natl Acad Sci U S A. 2023 Sep 12; 2023 Sep 5. PMID: 37669366.
Correction: Learnings from clinical trials in patients with connective tissue disease‑associated interstitial lung disease.Higuero Sevilla JP, Memon A, Hinchcliff M. Arthritis Res Ther. 2023 Jul 27; 2023 Jul 27. PMID: 37501068.
Learnings from clinical trials in patients with connective tissue disease-associated interstitial lung disease.Higuero Sevilla JP, Memon A, Hinchcliff M. Arthritis Res Ther. 2023 Jul 8; 2023 Jul 8. PMID: 37422652.
Clinical Phenotypes of Patients With Systemic Sclerosis With Distinct Molecular Signatures in Skin.Yang M, Goh V, Lee J, Espinoza M, Yuan Y, Carns M, Aren K, Chung L, Khanna D, McMahan ZH, Agrawal R, Nelson LB, Shah SJ, Whitfield ML, Hinchcliff M. Arthritis Care Res (Hoboken). 2023 Jul; 2023 Mar 13. PMID: 35997480.
Impaired left-ventricular global longitudinal strain by feature-tracking cardiac MRI predicts mortality in systemic sclerosis.Feher A, Miller EJ, Peters DC, Mojibian HR, Sinusas AJ, Hinchcliff M, Baldassarre LA. Rheumatol Int. 2023 May; 2023 Mar 10. PMID: 36894756.
Three Distinct Transcriptional Profiles of Monocytes Associate with Disease Activity in Scleroderma Patients.Makinde HM, Dunn JLM, Gadhvi G, Carns M, Aren K, Chung AH, Muhammad LN, Song J, Cuda CM, Dominguez S, Pandolfino JE, Dematte D'Amico JE, Budinger GS, Assassi S, Frech TM, Khanna D, Shaeffer A, Perlman H, Hinchcliff M, Winter DR. Arthritis Rheumatol. 2023 Apr; 2023 Feb 1. PMID: 36281773.
Human dermal fibroblast-derived exosomes induce macrophage activation in systemic sclerosis.Bhandari R, Yang H, Kosarek NN, Smith AE, Garlick JA, Hinchcliff M, Whitfield ML, Pioli PA. Rheumatology (Oxford). 2023 Feb 6. PMID: 35946522.
Differences in symptom experience among patients with systemic sclerosis: a cluster analytic approach to identifying subgroups.Murphy SL, Chen YT, Lee YC, Carns M, Aren K, Korman B, Hinchcliff M, Varga J. Rheumatology (Oxford). 2023 Feb 6. PMID: 35920770.
A Novel MIP-1-Expressing Macrophage Subtype in BAL Fluid from Healthy Volunteers.Reyfman PA, Malsin ES, Khuder B, Joshi N, Gadhvi G, Flozak AS, Carns MA, Aren K, Goldberg IA, Kim S, Alexander M, Sporn PHS, Misharin AV, Budinger GRS, Lam AP, Hinchcliff M, Gottardi CJ, Winter DR. Am J Respir Cell Mol Biol. 2023 Feb. PMID: 36174229.
Hyperspectral imaging in systemic sclerosis-associated Raynaud phenomenon.Teaw S, Gupta A, Williams A, Wilson FP, Sumpio BJ, Sumpio BE, Hinchcliff M. Arthritis Res Ther. 2023 Jan 20; 2023 Jan 20. PMID: 36670487.
Clinical and Autoantibody Associations in Antinuclear Antibody-Positive Systemic Sclerosis Lacking Prototypic Autoantibodies.Kruzer K, Goncalves Marangoni R, Heckler I, Elhage A, Varga J, Hinchcliff M, Carns M, Aren K, Wielgosz A, Nuzzo M, Venkataraman I, Korman B. J Clin Rheumatol. 2023 Jan 1; 2022 Jun 28. PMID: 35767831.
Circulating CTRP9 Is Associated With Severity of Systemic Sclerosis-Associated Interstitial Lung Disease.Yang MM, Balmert LC, Marangoni RG, Carns M, Hinchcliff M, Korman BD, Varga J. Arthritis Care Res (Hoboken). 2023 Jan; 2022 Aug 24. PMID: 34251759.
A genomic meta-analysis of clinical variables and their association with intrinsic molecular subsets in systemic sclerosis.Franks JM, Toledo DM, Martyanov V, Wang Y, Huang S, Wood TA, Spino C, Chung L, Denton CP, Derrett-Smith E, Gordon JK, Spiera R, Domsic R, Hinchcliff M, Khanna D, Whitfield ML. Rheumatology (Oxford). 2022 Dec 23. PMID: 35751592.
Epiregulin is a dendritic cell-derived EGFR ligand that maintains skin and lung fibrosis.Odell ID, Steach H, Gauld SB, Reinke-Breen L, Karman J, Carr TL, Wetter JB, Phillips L, Hinchcliff M, Flavell RA. Sci Immunol. 2022 Dec 16; 2022 Dec 9. PMID: 36490328.
Quantitative Evaluation of Aerosol Generation During In-Office Flexible Laryngoscopy.Bastien AJ, Wiredu K, Lee AY, Rees C, Hinchcliff MT, Paydarfar JA. JAMA Otolaryngol Head Neck Surg. 2022 Dec 1. PMID: 36301539.
FDG PET vascular imaging in IgG4-RD: Potential and challenges.Pucar D, Hinchcliff M. J Nucl Cardiol. 2022 Dec; 2021 Dec 28. PMID: 34964084.
Heterogeneity of primary and secondary peristalsis in systemic sclerosis: A new model of "scleroderma esophagus".Carlson DA, Prescott JE, Germond E, Brenner D, Carns M, Correia CS, Tetreault MP, McMahan ZH, Hinchcliff M, Kou W, Kahrilas PJ, Perlman HR, Pandolfino JE. Neurogastroenterol Motil. 2022 Jul; 2021 Oct 28. PMID: 34709690.
Lung Injury Induces Alveolar Type 2 Cell Hypertrophy and Polyploidy with Implications for Repair and Regeneration.Weng A, Maciel Herrerias M, Watanabe S, Welch LC, Flozak AS, Grant RA, Aillon RP, Dada LA, Han SH, Hinchcliff M, Misharin AV, Budinger GRS, Gottardi CJ. Am J Respir Cell Mol Biol. 2022 May. PMID: 35202558.
High-throughput identification of autoantibodies that target the human exoproteome.Wang EY, Dai Y, Rosen CE, Schmitt MM, Dong MX, Ferré EMN, Liu F, Yang Y, González-Hernández JA, Meffre E, Hinchcliff M, Koumpouras F, Lionakis MS, Ring AM. Cell Rep Methods. 2022 Feb 28; 2022 Feb 17. PMID: 35360706.
Cellular and Molecular Diversity in Scleroderma.Hinchcliff M, Garcia-Milian R, Di Donato S, Dill K, Bundschuh E, Galdo FD. Semin Immunol. 2021 Dec; 2022 Aug 6. PMID: 35940960.
Esophageal Dilation and Other Clinical Factors Associated With Pulmonary Function Decline in Patients With Systemic Sclerosis.Showalter K, Hoffmann A, Richardson C, Aaby D, Lee J, Dematte J, Agrawal R, Savas H, Wu X, Chang RW, Hinchcliff M. J Rheumatol. 2021 Dec; 2021 Jul 15. PMID: 34266985.
A review and roadmap of the skin, lung and gut microbiota in systemic sclerosis.Teaw S, Hinchcliff M, Cheng M. Rheumatology (Oxford). 2021 Dec 1. PMID: 33734316.
Impaired Myocardial Flow Reserve on (82)Rubidium Positron Emission Tomography/Computed Tomography in Patients With Systemic Sclerosis.Feher A, Boutagy NE, Oikonomou EK, Thorn S, Liu YH, Miller EJ, Sinusas AJ, Hinchcliff M. J Rheumatol. 2021 Oct; 2021 Jul 15. PMID: 34266986.
Association Between Impaired Myocardial Flow Reserve on (82)Rubidium Positron Emission Tomography Imaging and Adverse Events in Patients With Autoimmune Rheumatic Disease.Feher A, Boutagy NE, Oikonomou EK, Liu YH, Miller EJ, Sinusas AJ, Hinchcliff M. Circ Cardiovasc Imaging. 2021 Sep; 2021 Sep 10. PMID: 34503339.
Clinical characteristics, visceral involvement, and mortality in at-risk or early diffuse systemic sclerosis: a longitudinal analysis of an observational prospective multicenter US cohort.Jaafar S, Lescoat A, Huang S, Gordon J, Hinchcliff M, Shah AA, Assassi S, Domsic R, Bernstein EJ, Steen V, Elliott S, Hant F, Castelino FV, Shanmugam VK, Correia C, Varga J, Nagaraja V, Roofeh D, Frech T, Khanna D. Arthritis Res Ther. 2021 Jun 14; 2021 Jun 14. PMID: 34127049.
Predictive Significance of Serum Interferon-Inducible Protein Score for Response to Treatment in Systemic Sclerosis-Related Interstitial Lung Disease.Assassi S, Li N, Volkmann ER, Mayes MD, Rünger D, Ying J, Roth MD, Hinchcliff M, Khanna D, Frech T, Clements PJ, Furst DE, Goldin J, Bernstein EJ, Castelino FV, Domsic RT, Gordon JK, Hant FN, Shah AA, Shanmugam VK, Steen VD, Elashoff RM, Tashkin DP. Arthritis Rheumatol. 2021 Jun; 2021 Apr 20. PMID: 33350170.
The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study.Moledina DG, Simonov M, Yamamoto Y, Alausa J, Arora T, Biswas A, Cantley LG, Ghazi L, Greenberg JH, Hinchcliff M, Huang C, Mansour SG, Martin M, Peixoto A, Schulz W, Subair L, Testani JM, Ugwuowo U, Young P, Wilson FP. Am J Kidney Dis. 2021 Apr; 2021 Jan 8. PMID: 33422598.
Large-Scale Characterization of Systemic Sclerosis Serum Protein Profile: Comparison to Peripheral Blood Cell Transcriptome and Correlations With Skin/Lung Fibrosis.Bellocchi C, Ying J, Goldmuntz EA, Keyes-Elstein L, Varga J, Hinchcliff ME, Lyons MA, McSweeney P, Furst DE, Nash R, Crofford LJ, Welch B, Goldin JG, Pinckney A, Mayes MD, Sullivan KM, Assassi S. Arthritis Rheumatol. 2021 Apr; 2021 Feb 28. PMID: 33131208.
Mast Cell Activation in the Systemic Sclerosis Esophagus.Tom K, Mehta BK, Hoffmann A, Aren K, Carns M, Lee J, Martyanov V, Popovich D, Kosarek N, Wood T, Brenner D, Carlson DA, Ostilla L, Willcocks E, Bryce P, Wechsler JB, Whitfield ML, Hinchcliff M. J Scleroderma Relat Disord. 2021 Feb; 2020 Jul 27. PMID: 34179507.
Electronic health record alerts for acute kidney injury: multicenter, randomized clinical trial.Wilson FP, Martin M, Yamamoto Y, Partridge C, Moreira E, Arora T, Biswas A, Feldman H, Garg AX, Greenberg JH, Hinchcliff M, Latham S, Li F, Lin H, Mansour SG, Moledina DG, Palevsky PM, Parikh CR, Simonov M, Testani J, Ugwuowo U. BMJ. 2021 Jan 18; 2021 Jan 18. PMID: 33461986.
Computer vision applied to dual-energy computed tomography images for precise calcinosis cutis quantification in patients with systemic sclerosis.Chandrasekaran AC, Fu Z, Kraniski R, Wilson FP, Teaw S, Cheng M, Wang A, Ren S, Omar IM, Hinchcliff ME. Arthritis Res Ther. 2021 Jan 6; 2021 Jan 6. PMID: 33407814.
Performance Characteristics of Pulmonary Function Tests for the Detection of Interstitial Lung Disease in Adults With Early Diffuse Cutaneous Systemic Sclerosis.Bernstein EJ, Jaafar S, Assassi S, Domsic RT, Frech TM, Gordon JK, Broderick RJ, Hant FN, Hinchcliff ME, Shah AA, Shanmugam VK, Steen VD, Khanna D. Arthritis Rheumatol. 2020 Nov; 2020 Sep 22. PMID: 32583956.
Molecular "omic" signatures in systemic sclerosis.Mehta BK, Espinoza ME, Hinchcliff M, Whitfield ML. Eur J Rheumatol. 2020 Oct; 2020 Oct 1. PMID: 33164732.
Calcinosis is associated with ischemic manifestations and increased disability in patients with systemic sclerosis.Valenzuela A, Baron M, Rodriguez-Reyna TS, Proudman S, Khanna D, Young A, Hinchcliff M, Steen V, Gordon J, Hsu V, Castelino FV, Schoenfeld S, Li S, Wu JY, Fiorentino D, Chung L. Semin Arthritis Rheum. 2020 Oct; 2020 Jun 17. PMID: 32898758.
Regulator combinations identify systemic sclerosis patients with more severe disease.Wang Y, Franks JM, Yang M, Toledo DM, Wood TA, Hinchcliff M, Whitfield ML. JCI Insight. 2020 Sep 3; 2020 Sep 3. PMID: 32721949.
Lenabasum for Skin Disease in Patients With Diffuse Cutaneous Systemic Sclerosis.Hinchcliff M. Arthritis Rheumatol. 2020 Aug; 2020 Jul 4. PMID: 32368869.
Profibrotic Activation of Human Macrophages in Systemic Sclerosis.Bhandari R, Ball MS, Martyanov V, Popovich D, Schaafsma E, Han S, ElTanbouly M, Orzechowski NM, Carns M, Arroyo E, Aren K, Hinchcliff M, Whitfield ML, Pioli PA. Arthritis Rheumatol. 2020 Jul; 2020 May 31. PMID: 32134204.
Current and Potential New Targets in Systemic Sclerosis Therapy: a New Hope.Hinchcliff M, O'Reilly S. Curr Rheumatol Rep. 2020 Jun 19; 2020 Jun 19. PMID: 32562016.
High-throughput quantitative histology in systemic sclerosis skin disease using computer vision.Correia C, Mawe S, Lofgren S, Marangoni RG, Lee J, Saber R, Aren K, Cheng M, Teaw S, Hoffmann A, Goldberg I, Cowper SE, Khatri P, Hinchcliff M, Mahoney JM. Arthritis Res Ther. 2020 Mar 14; 2020 Mar 14. PMID: 32171325.
Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile.Skaug B, Khanna D, Swindell WR, Hinchcliff ME, Frech TM, Steen VD, Hant FN, Gordon JK, Shah AA, Zhu L, Zheng WJ, Browning JL, Barron AMS, Wu M, Visvanathan S, Baum P, Franks JM, Whitfield ML, Shanmugam VK, Domsic RT, Castelino FV, Bernstein EJ, Wareing N, Lyons MA, Ying J, Charles J, Mayes MD, Assassi S. Ann Rheum Dis. 2020 Mar; 2019 Nov 25. PMID: 31767698.
Complementary therapies for patients with systemic sclerosis.Showalter K, Hoffmann A, DeCredico N, Thakrar A, Arroyo E, Goldberg I, Hinchcliff M. J Scleroderma Relat Disord. 2019 Oct; 2019 Mar 29. PMID: 35382503.
Myeloablation followed by autologous stem cell transplantation normalises systemic sclerosis molecular signatures.Assassi S, Wang X, Chen G, Goldmuntz E, Keyes-Elstein L, Ying J, Wallace PK, Turner J, Zheng WJ, Pascual V, Varga J, Hinchcliff ME, Bellocchi C, McSweeney P, Furst DE, Nash RA, Crofford LJ, Welch B, Pinckney A, Mayes MD, Sullivan KM. Ann Rheum Dis. 2019 Oct; 2019 Aug 7. PMID: 31391177.
Connective Tissue Disease-Associated Interstitial Lung Disease: Evaluation and Management.Antin-Ozerkis D, Hinchcliff M. Clin Chest Med. 2019 Sep. PMID: 31376896.
Towards a new classification of systemic sclerosis.Hinchcliff M, Mahoney JM. Nat Rev Rheumatol. 2019 Aug. PMID: 31217541.
Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.Reyfman PA, Walter JM, Joshi N, Anekalla KR, McQuattie-Pimentel AC, Chiu S, Fernandez R, Akbarpour M, Chen CI, Ren Z, Verma R, Abdala-Valencia H, Nam K, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Watanabe S, Williams KJN, Flozak AS, Nicholson TT, Morgan VK, Winter DR, Hinchcliff M, Hrusch CL, Guzy RD, Bonham CA, Sperling AI, Bag R, Hamanaka RB, Mutlu GM, Yeldandi AV, Marshall SA, Shilatifard A, Amaral LAN, Perlman H, Sznajder JI, Argento AC, Gillespie CT, Dematte J, Jain M, Singer BD, Ridge KM, Lam AP, Bharat A, Bhorade SM, Gottardi CJ, Budinger GRS, Misharin AV. Am J Respir Crit Care Med. 2019 Jun 15. PMID: 30554520.
Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study.Scott MKD, Quinn K, Li Q, Carroll R, Warsinske H, Vallania F, Chen S, Carns MA, Aren K, Sun J, Koloms K, Lee J, Baral J, Kropski J, Zhao H, Herzog E, Martinez FJ, Moore BB, Hinchcliff M, Denny J, Kaminski N, Herazo-Maya JD, Shah NH, Khatri P. Lancet Respir Med. 2019 Jun; 2019 Mar 29. PMID: 30935881.
Normal Values of Esophageal Distensibility and Distension-Induced Contractility Measured by Functional Luminal Imaging Probe Panometry.Carlson DA, Kou W, Lin Z, Hinchcliff M, Thakrar A, Falmagne S, Prescott J, Dorian E, Kahrilas PJ, Pandolfino JE. Clin Gastroenterol Hepatol. 2019 Mar; 2018 Aug 3. PMID: 30081222.
The importance of technical skills assessment during an airway foreign body removal course.Hinchcliff M, Kao M, Johnson K. Int J Pediatr Otorhinolaryngol. 2019 Feb; 2018 Nov 9. PMID: 30579061.
Risk Factors for Mortality and Cardiopulmonary Hospitalization in Systemic Sclerosis Patients At Risk for Pulmonary Hypertension, in the PHAROS Registry.Hsu VM, Chung L, Hummers LK, Shah A, Simms R, Bolster M, Hant FN, Silver RM, Fischer A, Hinchcliff ME, Varga J, Goldberg AZ, Derk CT, Schiopu E, Khanna D, Shapiro LS, Domsic RT, Medsger T, Mayes MD, Furst D, Csuka ME, Molitor JA, Saketkoo LA, Salazar CR, Steen VD. J Rheumatol. 2019 Feb; 2018 Oct 1. PMID: 30275260.
Performance of Forced Vital Capacity and Lung Diffusion Cutpoints for Associated Radiographic Interstitial Lung Disease in Systemic Sclerosis.Showalter K, Hoffmann A, Rouleau G, Aaby D, Lee J, Richardson C, Dematte J, Agrawal R, Chang RW, Hinchcliff M. J Rheumatol. 2018 Nov; 2018 Oct 1. PMID: 30275265.
The Scleroderma Patient-Centered Intervention Network Cohort: baseline clinical features and comparison with other large scleroderma cohorts.Dougherty DH, Kwakkenbos L, Carrier ME, Salazar G, Assassi S, Baron M, Bartlett SJ, Furst DE, Gottesman K, van den Hoogen F, Malcarne VL, Mouthon L, Nielson WR, Poiraudeau S, Sauvé M, Boire G, Bruns A, Chung L, Denton C, Dunne JV, Fortin P, Frech T, Gill A, Gordon J, Herrick AL, Hinchcliff M, Hudson M, Johnson SR, Jones N, Kafaja S, Larché M, Manning J, Pope J, Spiera R, Steen V, Sutton E, Thorne C, Wilcox P, Thombs BD, Mayes MD. Rheumatology (Oxford). 2018 Sep 1. PMID: 29868924.
The novel adipokine C1q-TNF related protein 9 (CTRP9) is elevated in systemic sclerosis-associated interstitial lung disease.Korman B, Alejo R, Sudhakar D, Hinchcliff M, Agrawal R, Varga J, Marangoni RG. Clin Exp Rheumatol. 2018 Jul-Aug; 2018 Aug 28. PMID: 30183591.
Diffuse cardiac fibrosis quantification in early systemic sclerosis by magnetic resonance imaging and correlation with skin fibrosis.Lee DC, Hinchcliff ME, Sarnari R, Stark MM, Lee J, Koloms K, Hoffmann A, Carns M, Thakrar A, Aren K, Varga J, Aquino A, Carr JC, Benefield BC, Shah SJ. J Scleroderma Relat Disord. 2018 Jun; 2018 Apr 12. PMID: 29808171.
Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound-Guided Synovial Biopsies in Rheumatoid Arthritis.Mandelin AM 2nd, Homan PJ, Shaffer AM, Cuda CM, Dominguez ST, Bacalao E, Carns M, Hinchcliff M, Lee J, Aren K, Thakrar A, Montgomery AB, Bridges SL Jr, Bathon JM, Atkinson JP, Fox DA, Matteson EL, Buckley CD, Pitzalis C, Parks D, Hughes LB, Geraldino-Pardilla L, Ike R, Phillips K, Wright K, Filer A, Kelly S, Ruderman EM, Morgan V, Abdala-Valencia H, Misharin AV, Budinger GS, Bartom ET, Pope RM, Perlman H, Winter DR. Arthritis Rheumatol. 2018 Jun; 2018 May 3. PMID: 29439295.
Mycophenolate Mofetil Treatment of Systemic Sclerosis Reduces Myeloid Cell Numbers and Attenuates the Inflammatory Gene Signature in Skin.Hinchcliff M, Toledo DM, Taroni JN, Wood TA, Franks JM, Ball MS, Hoffmann A, Amin SM, Tan AU, Tom K, Nesbeth Y, Lee J, Ma M, Aren K, Carns MA, Pioli PA, Whitfield ML. J Invest Dermatol. 2018 Jun; 2018 Jan 31. PMID: 29391252.
Abnormal esophageal acid exposure on high-dose proton pump inhibitor therapy is common in systemic sclerosis patients.Stern EK, Carlson DA, Falmagne S, Hoffmann AD, Carns M, Pandolfino JE, Hinchcliff M, Brenner DM. Neurogastroenterol Motil. 2018 Feb; 2017 Nov 6. PMID: 29110377.
Brief Report: Association of Elevated Adipsin Levels With Pulmonary Arterial Hypertension in Systemic Sclerosis.Korman BD, Marangoni RG, Hinchcliff M, Shah SJ, Carns M, Hoffmann A, Ramsey-Goldman R, Varga J. Arthritis Rheumatol. 2017 Oct. PMID: 28651038.
Utility of B-type natriuretic peptides in the assessment of patients with systemic sclerosis-associated pulmonary hypertension in the PHAROS registry.Chung L, Fairchild RM, Furst DE, Li S, Alkassab F, Bolster MB, Csuka ME, Derk CT, Domsic RT, Fischer A, Frech TM, Gomberg-Maitland M, Gordon JK, Hinchcliff M, Hsu V, Hummers LK, Khanna D, Medsger TAJ, Molitor JA, Preston IR, Schiopu E, Shapiro L, Hant F, Silver R, Simms R, Varga J, Steen VD, Zamanian RT. Clin Exp Rheumatol. 2017 Sep-Oct; 2016 Nov 10. PMID: 27908301.
Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H. J Exp Med. 2017 Aug 7; 2017 Jul 10. PMID: 28694385.
Reliability and Validity of the Tender and Swollen Joint Counts and the Modified Rodnan Skin Score in Early Diffuse Cutaneous Systemic Sclerosis: Analysis from the Prospective Registry of Early Systemic Sclerosis Cohort.Gordon JK, Girish G, Berrocal VJ, Zhang M, Hatzis C, Assassi S, Bernstein EJ, Domsic RT, Hant FN, Hinchcliff M, Schiopu E, Steen VD, Frech TM, Khanna D. J Rheumatol. 2017 Jun; 2017 Mar 15. PMID: 28298560.
A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis.Taroni JN, Greene CS, Martyanov V, Wood TA, Christmann RB, Farber HW, Lafyatis RA, Denton CP, Hinchcliff ME, Pioli PA, Mahoney JM, Whitfield ML. Genome Med. 2017 Mar 23; 2017 Mar 23. PMID: 28330499.
Integrated, multicohort analysis of systemic sclerosis identifies robust transcriptional signature of disease severity.Lofgren S, Hinchcliff M, Carns M, Wood T, Aren K, Arroyo E, Cheung P, Kuo A, Valenzuela A, Haemel A, Wolters PJ, Gordon J, Spiera R, Assassi S, Boin F, Chung L, Fiorentino D, Utz PJ, Whitfield ML, Khatri P. JCI Insight. 2016 Dec 22; 2016 Dec 22. PMID: 28018971.
Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: A Scleroderma Clinical Trials Consortium study.Valenzuela A, Baron M, Herrick AL, Proudman S, Stevens W, Rodriguez-Reyna TS, Vacca A, Medsger TA Jr, Hinchcliff M, Hsu V, Wu JY, Fiorentino D, Chung L. Semin Arthritis Rheum. 2016 Dec; 2016 Jun 2. PMID: 27371996.
Fulminant capillary leak syndrome in a patient with systemic sclerosis treated with imatinib mesylate.Hinchcliff ME, Lomasney J, Johnson JA, Varga J. Rheumatology (Oxford). 2016 Oct; 2016 Jun 23. PMID: 27338086.
Comment on "Esophageal dilatation and interstitial lung disease in systemic sclerosis: A cross-sectional study".Hoffmann A, Lee J, Ma M, Agrawal R, Chang RW, Richardson C, Hinchcliff M, Showalter K. Semin Arthritis Rheum. 2016 Oct; 2016 May 6. PMID: 27312382.
Loss of Peristaltic Reserve, Determined by Multiple Rapid Swallows, Is the Most Frequent Esophageal Motility Abnormality in Patients With Systemic Sclerosis.Carlson DA, Crowell MD, Kimmel JN, Patel A, Gyawali CP, Hinchcliff M, Griffing WL, Pandolfino JE, Vela MF. Clin Gastroenterol Hepatol. 2016 Oct; 2016 Apr 5. PMID: 27062902.
Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial.Tashkin DP, Roth MD, Clements PJ, Furst DE, Khanna D, Kleerup EC, Goldin J, Arriola E, Volkmann ER, Kafaja S, Silver R, Steen V, Strange C, Wise R, Wigley F, Mayes M, Riley DJ, Hussain S, Assassi S, Hsu VM, Patel B, Phillips K, Martinez F, Golden J, Connolly MK, Varga J, Dematte J, Hinchcliff ME, Fischer A, Swigris J, Meehan R, Theodore A, Simms R, Volkov S, Schraufnagel DE, Scholand MB, Frech T, Molitor JA, Highland K, Read CA, Fritzler MJ, Kim GHJ, Tseng CH, Elashoff RM. Lancet Respir Med. 2016 Sep; 2016 Jul 25. PMID: 27469583.
Esophageal dilatation and interstitial lung disease in systemic sclerosis: A cross-sectional study.Richardson C, Agrawal R, Lee J, Almagor O, Nelson R, Varga J, Cuttica MJ, Dematte JD, Chang RW, Hinchcliff ME. Semin Arthritis Rheum. 2016 Aug; 2016 Feb 26. PMID: 27033049.
The association between systemic sclerosis disease manifestations and esophageal high-resolution manometry parameters.Kimmel JN, Carlson DA, Hinchcliff M, Carns MA, Aren KA, Lee J, Pandolfino JE. Neurogastroenterol Motil. 2016 Aug; 2016 Feb 27. PMID: 26921101.
Tenascin-C drives persistence of organ fibrosis.Bhattacharyya S, Wang W, Morales-Nebreda L, Feng G, Wu M, Zhou X, Lafyatis R, Lee J, Hinchcliff M, Feghali-Bostwick C, Lakota K, Budinger GR, Raparia K, Tamaki Z, Varga J. Nat Commun. 2016 Jun 3; 2016 Jun 3. PMID: 27256716.
The relationship between skin symptoms and the scleroderma modification of the health assessment questionnaire, the modified Rodnan skin score, and skin pathology in patients with systemic sclerosis.Ziemek J, Man A, Hinchcliff M, Varga J, Simms RW, Lafyatis R. Rheumatology (Oxford). 2016 May; 2016 Feb 15. PMID: 26880832.
Genetic susceptibility loci of idiopathic interstitial pneumonia do not represent risk for systemic sclerosis: a case control study in Caucasian patients.Wu M, Assassi S, Salazar GA, Pedroza C, Gorlova OY, Chen WV, Charles J, Taing ML, Liao K, Wigley FM, Hummers LK, Shah AA, Hinchcliff M, Khanna D, Schiopu E, Phillips K, Furst DE, Steen V, Baron M, Hudson M, Zhou X, Pope J, Jones N, Docherty P, Khalidi NA, Robinson D, Simms RW, Silver RM, Frech TM, Fessler BJ, Fritzler MJ, Molitor JA, Segal BM, Movahedian M, Martín J, Varga J, Mayes MD. Arthritis Res Ther. 2016 Jan 20; 2016 Jan 20. PMID: 26792595.
Survival in systemic sclerosis-pulmonary arterial hypertension by serum autoantibody status in the Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma (PHAROS) Registry.Hinchcliff M, Khanna S, Hsu VM, Lee J, Almagor O, Chang RW, Steen V, Chung L. Semin Arthritis Rheum. 2015 Dec; 2015 Jun 19. PMID: 26210782.
Molecular characterization of systemic sclerosis esophageal pathology identifies inflammatory and proliferative signatures.Taroni JN, Martyanov V, Huang CC, Mahoney JM, Hirano I, Shetuni B, Yang GY, Brenner D, Jung B, Wood TA, Bhattacharyya S, Almagor O, Lee J, Sirajuddin A, Varga J, Chang RW, Whitfield ML, Hinchcliff M. Arthritis Res Ther. 2015 Jul 29; 2015 Jul 29. PMID: 26220546.
Cardiac metabolomics and autopsy in a patient with early diffuse systemic sclerosis presenting with dyspnea: a case report.Frech TM, Revelo MP, Ryan JJ, Shah AA, Gordon J, Domsic R, Hant F, Assassi S, Shanmugam VK, Hinchcliff M, Steen V, Khanna D, Bernstein EJ, Cox J, Luem N, Drakos S. J Med Case Rep. 2015 Jun 10; 2015 Jun 10. PMID: 26055398.
Antinuclear antibody-negative systemic sclerosis.Salazar GA, Assassi S, Wigley F, Hummers L, Varga J, Hinchcliff M, Khanna D, Schiopu E, Phillips K, Furst DE, Steen V, Baron M, Hudson M, Taillefer SS, Pope J, Jones N, Docherty P, Khalidi NA, Robinson D, Simms RW, Silver RM, Frech TM, Fessler BJ, Molitor JA, Fritzler MJ, Segal BM, Al-Kassab F, Perry M, Yang J, Zamanian S, Reveille JD, Arnett FC, Pedroza C, Mayes MD. Semin Arthritis Rheum. 2015 Jun; 2014 Nov 28. PMID: 25578738.
A candidate gene study reveals association between a variant of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) gene and systemic sclerosis.Marangoni RG, Korman BD, Allanore Y, Dieude P, Armstrong LL, Rzhetskaya M, Hinchcliff M, Carns M, Podlusky S, Shah SJ, Ruiz B, Hachulla E, Tiev K, Cracowski JL, Varga J, Hayes MG. Arthritis Res Ther. 2015 May 19; 2015 May 19. PMID: 25986483.
The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling.Wei J, Ghosh AK, Chu H, Fang F, Hinchcliff ME, Wang J, Marangoni RG, Varga J. Arthritis Rheumatol. 2015 May. PMID: 25707573.
Serum amyloid A is a marker for pulmonary involvement in systemic sclerosis.Lakota K, Carns M, Podlusky S, Mrak-Poljsak K, Hinchcliff M, Lee J, Tomsic M, Sodin-Semrl S, Varga J. PLoS One. 2015; 2015 Jan 28. PMID: 25629975.
Experimentally-derived fibroblast gene signatures identify molecular pathways associated with distinct subsets of systemic sclerosis patients in three independent cohorts.Johnson ME, Mahoney JM, Taroni J, Sargent JL, Marmarelis E, Wu MR, Varga J, Hinchcliff ME, Whitfield ML. PLoS One. 2015; 2015 Jan 21. PMID: 25607805.