Selected Publications

  1. Saddouk FZ, Ntokou A, Greif DM.  Invited chapter: Specialized smooth muscle cell progenitors in pulmonary hypertension. In: T.Naknishi, H. Baldwin, J Fineman, and H Yamagishi, ediotrs. Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension.  Springer Nature, 2018. In press.
  2. Ntokou, A, Greif, DM. (2018). Vagal nerve stimulation for pulmonary hypertension: some promise, some skepticism. Journal of the American College of Cardiology: Basic to Translational Science, 3:672.
  3. Dubrac A, Kunzel, SE, Kunzel, SH, Li, J, Chandran, RR, Martin, K, Greif, DM, Adams, R, Eichmann, A.  (2018) Nck-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy. Nature Communications, 9:3463.
  4. Misra, A, Feng, Z, Chandran, RR, Kabir, I, Rotllan, N, Aryal, B, Sheikh, AQ, Ding, L, Qin, L, Fernandez-Hernando, C, Tellides, G, Greif, DM. (2018). Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells. Nature Communications, 9:2073. doi:10.1038/s41467.018.04447.7
  5. Sheikh, AQ, Saddouk, FZ, Ntokou, A., Mazurek, R, Greif, DM.  (2018) Cell autonomous and non-cell autonomous regulation of SMC progenitors in pulmonary hypertension.  Cell Reports, 23:1152. doi:10.1016/j.celrep.2018.03.043
  6. Ntokou, A, Kabir, I, Saddouk, FZ, Greif, DM.  Invited chapter: Vascular embryology and angiogenesis.  In: Vascular Medicine, A Companion to Braunwald's Heart Disease, 3rd edition. M. Creager, J. Beckham, J. Loscalzo, editors.  Philadelphia, PA: Elsevier Inc., 2018, in press.
  7. Dave, JM, Mirabella, T, Greif, DM. (2018) ALK5/TIMP3 axis is pericytes contributes to endothelial morphogenesis in the developing brain. Developmental Cell, 44: 665-678. doi:10.1016/j/devcel.2018.01.018
  8. Greif, DM*, Eichmann, A*. (2017). Where do new endothelial cells come from in the injured heart?  Nature Reviews. Cardiology, 14:507. (*Co-corresponding authors).  doi:10.1038/nrcardio.2017.121 
  9. Misra, A, Feng, Z, Zhang, J, Lou, Z, Greif, DM. (2017). Using in vivo and tissue cell explant approaches to study morphogenesis and pathogenesis of the embryonic and perinatal aorta. Journal of Visualized Experiments, 127, e56039.  doi:10.3791/56039 
  10. Jiao, Y, Li, G, Li, Q, Ali, R, Qin, L, Li, W, Qyang, Y, Greif, DM, Geirsson, A,  Humphrey, JD and Tellides, G. (2017). mTOR inhibition decreases mechanosignaling, collagen accumulation, and stiffening of the aorta in elastin-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 37:1657-1666.  http://doi.org/10.1161/ATVBAHA.117.309653
  11. Mazurek, R, Dave, JM, Chandran, RR, Misra, A, Sheikh, AQ, Greif, DM. Invited chapter: Vascular cells in blood vessel development and disease. In: Raouf A. Khalil, editor. Vascular Pharmacology, Vol 78, APHA, UK: Academic Press, 2017, pp. 323-350 doi.org/10.1016/bs.apha.2016.08.001    
  12. Misra A, Sheikh AQ, Ding L, Kumar A, Hinton RB, Smoot L, Kaplan P, Urban Z, Qyang Y, Tellides G, Greif DM. Integrin beta3 inhibition is a therapeutic strategy for supravalvular aortic stenosis. Journal of Experimental Medicine. 2016, 213:451-463. doi:10.1084/jem.20150688
  13. Sheikh AQ, Misra A, Rosas IO, Adams RH, Greif DM. Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension. Science Translational Medicine. 2015, 7:308ra159. doi:10.1126/scitranslmed.aaa9712
  14. Sheikh AQ, Lighthouse JK, Greif DM. Recapitulation of developing artery muscularization in pulmonary hypertension. Cell Reports. 2014, 6:809-17.  doi:10.1016/j.celrep.2014.01.04
  15. Seidelman S, Lighthouse JK, Greif DM.  Development and pathologies of the arterial vascular wall. Cellular and Molecular Life Sciences. 2014, 71:1977-99.  doi: 10.1007/s00018-013-1478-y
  16. Greif DM*, Eichmann A*. Vascular biology:brain vessels squeezed to death. Nature. 2014, 508:50-1. (*Co-corresponding authors). doi:10.1038/nature13217
  17. Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, McLean DL, Park H, Comhair SA, Greif DM, Erzurum SC, Chun HJ.  A novel endothelial Apelin-FGF link mediated by MicroRNAs 424 and 503 is disrupted in pulmonary arterial hypertension. Nature Medicine. 2013, 19:74-82. PMC3540168
  18. Greif DM.  Invited chapter: Vascular embryology and angiogenesis.  In: Vascular Medicine, A Companion to Braunwald's Heart Disease, 2nd edition. M. Creager, J. Beckman, J. Loscalzo, editors. Philadelphia, PA: Elsevier Inc., 2012, p. 1-13. doi:10.1016/B978-1-4377-2930-6.00001-X
  19. Greif DM*, Kumar M, Lighthouse JK, Hum J, An A, Ding L, Red-horse K, Espinoza FH, Olson L, Offermanns S, Krasnow, MA*.  Radial construction of an arterial wall. Developmental Cell. 2012, 23:482-93. (*Co-corresponding authors). PMC3500096
  20. London NR, Zhu W, Bozza FA, Smith MC, Greif DM, Sorensen LK, Chen L, Kaminoh Y, Chan AC, Passi SF, Day CW, Barnard DL, Zimmerman GA, Krasnow MA, Li DY.  Targeting Robo4-dependent slit signaling to survive the cytokine storm in sepsis and influenza. Science Translational Medicine. 2010, 23ra19. PMC2875996
  21. Dudzinski DM, Igarashi J, Greif DM, Michel T.  The regulation and pharmacology of endothelial nitric oxide synthase. Annual Review of Pharmacology and Toxicology. 2006, 46:235-76. doi:10.1146/annurev.pharmtox.44.101802.121844
  22. SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Garcia-Cardena G, Gimbrone MA, Jain MK.  KLF2 is a novel transcriptional regulator of proinflammatory activation. The Journal of Experimental Medicine. 2004, 199:1305-15. PMC2211816
  23. Greif DM, Sacks DB, Michel T.  Calmodulin phosphorylation and modulation of endothelial nitric oxide synthase catalysis. Proceedings of the National Academy of Sciences. 2004, 101:1165-1170. PMC337024
  24. Greif DM, Kou R, Michel T.  Regulation of eNOS dephosphorylation by protein phosphatase 2A: evidence for crosstalk between phosphorylation sites. Biochemistry. 2002, 41:15845-53. doi:10.1021/bio26732g
  25. Kou R, Greif D, Michel, T. Dephosphorylation of endothelial nitric-oxide synthase by vascular endothelial growth factor. Implications for the vascular responses to cyclosporin A. Journal of Biological Chemistry. 2002, 277:29669-73. doi: 10.1074/jbc.M204519200
  26. Goetz DJ, Greif DM, Shen J, Luscinskas FW.  Cell-cell adhesive interactions in an in vitro fluid flow assay. Methods in Molecular Biology. 1999, 96:137-145. doi:10.1385/1-59259-258-9:137 
  27. Greif DM+, Goetz DJ+, Ding H, Camphausen RT, Howes S, Comess KM, Snapp KR, Kansas GS, Luscinskas FW.  Isolated PSGL-1 dynamic adhesion to P- and E-selectin. Journal of Cell Biology. 1997, 137:509-519. (+These authors contributed equally and are listed alphabetically on publication). PMC2139768 
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Muscularized pulmonary vasculature in pulmonary hypertension