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  • Crosstalk between cells plays role in pulmonary hypertension

    Pulmonary hypertension is a type of high blood pressure that affects blood vessels in the lungs. Once diagnosed, patients have limited treatment options, and many do not live beyond seven years. In a new study, scientists in the Yale Cardiovascular Research Center have gained new insight into the development of the disease that could lead to new therapies.

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  • Study identifies potential therapy for disease affecting preemies

    One in five very low-birth-weight, premature infants suffers a life-threatening brain hemorrhage, often originating in a vital region known as the germinal matrix. In a recently published study in the journal Developmental Cell, Yale researchers identified a protein that lessens the hemorrhaging in embryonic mice, and they say could potentially serve as a therapy in affected humans.

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  • Medical faculty elected to the American Society for Clinical Investigation

    Drs. Daniel Greif, Cary Gross, Chirag Parikh, and Joseph Ross of Yale School of Medicine have been elected to the American Society for Clinical Investigation (ASCI). One of the nation’s oldest and most prestigious medical honor societies, ASCI supports the work of top physician-scientists whose research improves human health.

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  • Yale study provides a breath of hope for pulmonary hypertension patients

    Most of us draw roughly 25,000 breaths a day without any thought. But for patients with pulmonary hypertension, a life-threatening increase in blood pressure in the lungs, even the smallest task can leave them gasping for air. A new study by researchers at Yale School of Medicine offers insight into the function of cells linked to this incurable and often fatal illness.

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  • Radial Construction of an Arterial Wall

    Some of the most serious diseases involve altered size and structure of the arterial wall. Elucidating how arterial walls are built could aid understanding of these diseases, but little is known about how concentric layers of muscle cells and the outer adventitial layer are assembled and patterned around endothelial tubes. Using histochemical, clonal, and genetic analysis in mice, here we show that the pulmonary artery wall is constructed radially, from the inside out, by two separate but coordinated processes. One is sequential induction of successive cell layers from surrounding mesenchyme. The other is controlled invasion of outer layers by inner layer cells through developmentally regulated cell reorientation and radial migration. We propose that a radial signal gradient controls these processes and provide evidence that PDGF-B and at least one other signal contribute.

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