The American Heart Association has awarded to Daniel Greif, MD a grant to study the mechanisms of reverse vascular remodeling in pulmonary hypertension.
- May 25, 2018
In a new study, Yale researchers investigate how plaque cells develop at the molecular level, and their findings could help produce targeted treatments for the disease.
- April 24, 2018
Pulmonary hypertension is a type of high blood pressure that affects blood vessels in the lungs. Once diagnosed, patients have limited treatment options, and many do not live beyond seven years. In a new study, scientists in the Yale Cardiovascular Research Center have gained new insight into the development of the disease that could lead to new therapies.
- March 12, 2018
One in five very low-birth-weight, premature infants suffers a life-threatening brain hemorrhage, often originating in a vital region known as the germinal matrix. In a recently published study in the journal Developmental Cell, Yale researchers identified a protein that lessens the hemorrhaging in embryonic mice, and they say could potentially serve as a therapy in affected humans.
- February 21, 2018
Drs. Daniel Greif, Cary Gross, Chirag Parikh, and Joseph Ross of Yale School of Medicine have been elected to the American Society for Clinical Investigation (ASCI). One of the nation’s oldest and most prestigious medical honor societies, ASCI supports the work of top physician-scientists whose research improves human health.
- January 01, 2016
Smooth Move: In the mouse lung, hardening of a blood vessel can result from just a single progenitor cell forming new smooth muscle.
Previous research in mice from Yale University’s Daniel Greif and colleagues found that oxygen deprivation (hypoxia), which can cause PH in humans and animal models, leads smooth muscle cells (SMCs) in the proximal and middle arteriole to dedifferentiate, migrate distally, and redifferentiate to form new muscle.
- October 07, 2015
Cardiovascular diseases are the leading cause of death worldwide. As a prime example, pulmonary hypertension is especially lethal, with one-half of patients dying within three years of being diagnosed. Yale researchers have uncovered a novel cell type that is essential to the development of pulmonary hypertension and promises to lead to improved therapies.
- February 27, 2014
Most of us draw roughly 25,000 breaths a day without any thought. But for patients with pulmonary hypertension, a life-threatening increase in blood pressure in the lungs, even the smallest task can leave them gasping for air. A new study by researchers at Yale School of Medicine offers insight into the function of cells linked to this incurable and often fatal illness.
- September 12, 2012
Some of the most serious diseases involve altered size and structure of the arterial wall. Elucidating how arterial walls are built could aid understanding of these diseases, but little is known about how concentric layers of muscle cells and the outer adventitial layer are assembled and patterned around endothelial tubes. Using histochemical, clonal, and genetic analysis in mice, here we show that the pulmonary artery wall is constructed radially, from the inside out, by two separate but coordinated processes. One is sequential induction of successive cell layers from surrounding mesenchyme. The other is controlled invasion of outer layers by inner layer cells through developmentally regulated cell reorientation and radial migration. We propose that a radial signal gradient controls these processes and provide evidence that PDGF-B and at least one other signal contribute.