Welcome to Greif Lab
Cardiovascular disease and lung disease are major causes of death globally. My laboratory utilizes multi-disciplinary approaches to investigate how blood vessels initially form, are maintained and go awry in disease. In addition, we study the role of alveolar myofibroblasts in lung development and fibrotic disease. Our research spans from cultured cells to mouse models to human samples. We aim to gain critical insights into pathogenesis of diverse cardiovascular and pulmonary pathologies and leverage these insights into novel therapeutics for human disease.
Current Research Projects:
- Excess smooth muscle in pulmonary hypertension: cell autonomous and non-cell autonomous regulation.
- Aortic wall development and disease (atherosclerosis, supravalvular aortic stenosis): progenitor cell specification, migration and differentiation.
- Mural cell signaling and blood brain barrier formation: implications for intracerebral hemorrhage.
- Alveolar myofibroblasts in lung development and fibrotic disease.