Yale Study Shows Combined Liver–Cytokine Humanization Rescues Circulating Red Blood Cells for Testing of Novel Therapeutics
In a new study by the Yale Department of Immunobiology and Yale Cancer Center, researchers report combined liver and growth factor humanization enhances human red blood cell production and survival in circulation the immunodeficient murine host.
Suspect cells' 'neighbor' implicated in colorectal cancer
Cancer researchers have zeroed in on a tightly sequestered group of stem cells within the intestine as suspects in the development of colon cancer but have been unable to explain exactly how genetic mutations within those stem cells can cause tumors of the digestive track.
How T Cells Make Sure They Have Quiet Time
All cells, like all people, need “quiet” time to function properly, and this is particularly true of T cells, one of the immune system’s main weapons. They must be ready for activation at all times, and primed to divide more rapidly than almost any cell in the body.
Humanized Mice Lead to Breakthroughs in Blood Cancers
Humanized mice created at Yale are opening new avenues of research into cancers caused by disorders in the production of blood, such as acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS). Until recently, such research was hindered because human blood stem cells are difficult to grow in cell cultures or to engraft in mice.
Richard Flavell Is Named a Distinguished Fellow by the American Association of Immunologists
Richard A. Flavell, PhD, is one of 20 scientists who have been named Distinguished Fellows by the American Association of Immunologists, which recognizes members for distinguished careers and outstanding scientific contributions, as well as their service to AAI and the immunology community. It is one of the highest honors that AAI bestows.
Mechanical forces impact immune response in the lungs
Mechanical forces impact immune response in the lungs By Ziba Kashef August 21, 2019 Share this with Facebook Share this with Twitter Share this with LinkedIn Share this with Email Print this 3d rendered medically accurate illustration of a mans lung (© stock.adobe.com) When the body is fending off an infection, there are changes in temperature, pH balance, and metabolism. Yale researchers wondered if yet other factors might come into play, and in a recent study, confirmed that mechanical forces also influence the immune response.
Study Explores Role of Metabolism in Immune Cell Behavior
What makes healthy cells change and become dysfunctional to the point of causing disease? In addition to a disruption in genes that regulate cells, there is another factor in cell misbehavior that involves metabolism, say Yale researchers.
Yale scientists study genes misidentified as ‘non-protein coding’
The human genome contains regions that “code” for proteins, which means they have instructions to make protein molecules with specific functions in the body. But Yale researchers have discovered several protein-coding genes that were misidentified as non-protein-coding, and one in particular that plays a key role in the immune system.
Combination immunotherapy targets cancer resistance
Cancer immunotherapy drugs have had notable but limited success because in many cases, tumors develop resistance to treatment. But researchers at Yale and Stanford have identified an experimental antibody that overcomes this problem by targeting a wider range of immune cells linked to tumor grow
Could modifying gut microbes prevent or delay type 1 diabetes?
Autoimmune diseases such as type 1 diabetes are controlled by our genes. While researchers are eager to find out what other factors could contribute to this disease, a new study published by Yale researchers provides direct evidence that environmental factors, such as microbes that inhabit our intestines, may influence the incidence of the disease.
Study pinpoints protein key to fighting a common intestinal illness
Rotavirus is the most common cause of diarrhea in infants and young children worldwide. It is highly infectious and potentially deadly. The virus, which has evolved strategies to evade the immune system, is the focus of new research lead by immunologist Richard Flavell and published in Nature.
Study pinpoints protein that detects damage from radiation
High doses of radiation from cancer treatment can cause severe damage to cells and tissues, resulting in injury to bone marrow and the gastrointestinal tract. The consequences can be fatal. Yet researchers do not fully understand how exposure to radiation triggers this damage at the molecular level.
Yale researchers design new cancer research model
Yale researchers have designed the first mouse model that successfully mimics the growth of various stages of myeloma cancer in humans, opening a new door for myeloma research. The researchers, led by School of Medicine professors Richard Flavell and Madhav Dhodapkar, developed a robust in-vivo model to grow and investigate individual myeloma tumors. According to the investigators, this model — which simulates the environment of the human bone marrow in which the cancer develops — is crucial, as it can now be used to screen potential myeloma treatments to develop more effective therapeutic approaches.Source: Yale Daily News
Multiple Myeloma Studied in New Mouse Model Developed at Yale
Understanding how multiple myeloma develops and responds to therapies may be easier using a new mouse model developed at Yale University School of Medicine. The model supports the growth of cells derived from patients with multiple myeloma or the disease’s precursor states.Source: Myeloma Research News