The Engelman Lab and colleagues are pursuing applications of the novel pH-responsive transmembrane peptides, pHLIPs, for translational and basic research applications in membrane biophysics and medicine.
Membrane protein folding and oligomerization often involve interactions between lipid solvated monomeric alpha-helices, and further associations of the helices into higher order states. The two states of the simplest example of this equilibrium, monomers and a homodimer, are cartooned below.
Ongoing work in the lab is focusing on multiple applications of the pHLIP delivery platform.
The Engelman Lab maintains interdisciplinary collaborations with several research groups both inside Yale and with groups around the US.