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  • The Engelman Lab and colleagues are pursuing applications of the novel pH-responsive transmembrane peptides, pHLIPs, for translational and basic research applications in membrane biophysics and medicine.

  • Membrane protein folding and oligomerization often involve interactions between lipid solvated monomeric alpha-helices, and further associations of the helices into higher order states. The two states of the simplest example of this equilibrium, monomers and a homodimer, are cartooned below.

  • Ongoing work in the lab is focusing on multiple applications of the pHLIP delivery platform.

  • The Engelman Lab maintains interdisciplinary collaborations with several research groups both inside Yale and with groups around the US.