Vinod H. Srihari, MD
Professor of PsychiatryCards
About
Research
Overview
Medical Research Interests
Biomarkers; Curriculum; Evidence-Based Medicine; Exosomes; Health Care Quality, Access, and Evaluation; Learning Health System; Mental Health Services; Mitochondrial Diseases; Oxidative Stress; Population Health; Psychotic Disorders; Public Health Informatics; Schizophrenia Spectrum and Other Psychotic Disorders
Public Health Interests
Capacity Building; Health Policy
Publications
2025
Deep multimodal representations and classification of first-episode psychosis via live face processing
Singh R, Zhang Y, Bhaskar D, Srihari V, Tek C, Zhang X, Noah J, Krishnaswamy S, Hirsch J. Deep multimodal representations and classification of first-episode psychosis via live face processing. Frontiers In Psychiatry 2025, 16: 1518762. PMID: 40134976, PMCID: PMC11934110, DOI: 10.3389/fpsyt.2025.1518762.Peer-Reviewed Original ResearchFirst-episode psychosisPositive and Negative Syndrome ScaleFunctional near-infrared spectroscopyGlobal Assessment of FunctioningEarly psychosisNeural correlates of social cognitionFirst-episode psychosis individualsNegative Syndrome ScaleBehavior recordsAssessment of FunctioningSevere psychiatric disordersSyndrome ScaleFace processingPsychosis symptomsNeural underpinningsSocial cognitionNeural correlatesPsychiatric disordersBrain activitySocial difficultiesNeurophysiological dysfunctionPsychosisNeural characteristicsMultimodal representationsAcquisition paradigmThe impact of Duration of Untreated Psychosis on functioning and quality of life over one year of Coordinated Specialty Care (CSC)
Hazan H, Tayfur S, Zhou B, Li F, Gibbs-Dean T, Karmani S, Kline E, Ferrara M, Corbera S, Riley S, Sykes L, Tek C, Keshavan M, Srihari V. The impact of Duration of Untreated Psychosis on functioning and quality of life over one year of Coordinated Specialty Care (CSC). PLOS ONE 2025, 20: e0312740. PMID: 39928579, PMCID: PMC11809850, DOI: 10.1371/journal.pone.0312740.Peer-Reviewed Original ResearchConceptsCoordinated specialty careQuality of lifeDuration of untreated psychosisDUP groupWorld Health OrganizationYear of coordinated specialty careGeneralized linear modelConfidence intervalsBinary outcomesGlobal functioningDuration of untreated psychosis groupSymptom severityUntreated psychosisSpecialty careCSC programsImpact of duration of untreated psychosisFunctional gainsModel repeated measuresMixed model repeated measuresOdds ratioNo significant differenceLogit link functionStatus improvementContinuous outcomesSocial functioningSex differences in clozapine prescription: results from an Italian 30-year health records registry
Ferrara M, Domenicano I, Bellagamba A, Zaffarami G, Benini L, Sorio C, Gentili E, Srihari V, Grassi L. Sex differences in clozapine prescription: results from an Italian 30-year health records registry. Journal Of Psychiatric Research 2025 DOI: 10.1016/j.jpsychires.2025.02.019.Peer-Reviewed Original ResearchAntipsychotics to clozapineSchizophrenia spectrum disordersDiagnosis of schizophreniaClozapine prescriptionPrescribed clozapineSpectrum disorderDiagnosis of schizophrenia spectrum disorderBarriers to clozapine useTreatment-resistant schizophreniaOutpatient psychiatric servicesGender-specific biasesClozapine useBackground ClozapineSchizophrenia diagnosisClozapineSchizophreniaSex differencesPrescribed to womenClinical confounding factorsDisordersFemale patientsHazard ratioAntipsychoticsAdequate treatmentPatientsMeasurement properties of instruments to assess insight in psychosis: A systematic review protocol
Hazan H, Funaro M, Srihari V. Measurement properties of instruments to assess insight in psychosis: A systematic review protocol. PLOS ONE 2025, 20: e0316447. PMID: 39854417, PMCID: PMC11759350, DOI: 10.1371/journal.pone.0316447.Peer-Reviewed Original ResearchConceptsMeasurement properties of instrumentsProperties of instrumentsSystematic reviewCOSMIN Risk of Bias checklistRisk of Bias checklistMeasurement propertiesMeasure methodological qualityMeta-Analysis ProtocolsSynthesize current evidenceSystematic review protocolPreferred Reporting ItemsClinical practicePeer-reviewed journalsStrength of evidenceSemi-structured interviewsBias checklistImprove careMental illnessMethodological qualityReporting ItemsPatient awarenessPRISMA-PReview protocolGRADE approachSelf-reportInsight and suicidality in first-episode psychosis: The mediating role of depression
Tayfur S, Song Z, Li F, Hazan H, Gibbs-Dean T, Purushothaman D, Karmani S, Terashima J, Tek C, Srihari V. Insight and suicidality in first-episode psychosis: The mediating role of depression. Schizophrenia Research 2025, 275: 189-195. PMID: 39754935, DOI: 10.1016/j.schres.2024.12.013.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisPredictors of suicideCoordinated specialty careTreatment of depressionPersistence of depressionEffects of depressionSuicide attemptsMediation analysisPrevent suicideDepressionSuicideImpact suicidePsychosisTargeted interventionsLongitudinal cohort studyEarly treatment stageParticipantsSignificant predictorsImproving clinical outcomesRegression analysisSpecialty careClinical outcomesCohort studyRelationshipMonths
2024
The Academic Community Early Psychosis Intervention Network: Toward building a novel learning health system across six US states
Vohs J, Srihari V, Vinson A, Lapidos A, Cahill J, Taylor S, Heckers S, Weiss A, Chaudhry S, Silverstein S, Tso I, Breitborde N, Breier A. The Academic Community Early Psychosis Intervention Network: Toward building a novel learning health system across six US states. Learning Health Systems 2024 DOI: 10.1002/lrh2.10471.Peer-Reviewed Original ResearchEarly Psychosis Intervention NetworkIntervention NetworkFirst-episode psychosisRegional clinical networksLearning health systemQuality improvement projectQuality improvement effortsCulture of continuous learningData elementsPrimary diagnosis of schizophreniaConsecutive 6-month intervalsFirst-episode psychosis clinicUsual careSuperior patient outcomesSpecialty servicesHealth systemClinical teamImplementation meetingsQuality assurance effortsImprovement projectClinical networksHealthcare systemPractice-based researchImprovement effortsQuality improvementThe anomalous effect of COVID-19 pandemic restrictions on the duration of untreated psychosis
Nicholls-Mindlin J, Hazan H, Zhou B, Li F, Ferrara M, Levine N, Riley S, Karmani S, Mathis W, Keshavan M, Srihari V. The anomalous effect of COVID-19 pandemic restrictions on the duration of untreated psychosis. BJPsych Open 2024, 10: e216. PMID: 39628123, PMCID: PMC11698182, DOI: 10.1192/bjo.2024.813.Peer-Reviewed Original ResearchTimelinePTC: Development of a unified interface for pathways to care collection, visualization, and collaboration in first episode psychosis
Mathis W, Ferrara M, Cahill J, Karmani S, Tayfur S, Srihari V. TimelinePTC: Development of a unified interface for pathways to care collection, visualization, and collaboration in first episode psychosis. PLOS ONE 2024, 19: e0302116. PMID: 39028697, PMCID: PMC11259254, DOI: 10.1371/journal.pone.0302116.Peer-Reviewed Original ResearchConceptsPathways to CareDuration of untreated psychosisManual transcription errorsDevelopment of targeted interventionsReduce duration of untreated psychosisHealthcare accessibility researchReal-time data entryImprove patient outcomesEpisode psychosisCare pathwaysPatient journeyHealthcare contextPatient outcomesPaper-basedConversion of collected dataFEP treatmentData collection processNew HavenData collection methodsData entryTranscription errorsUntreated psychosisOpen-source codebaseData collectionWeb-based toolThe Italian adaptation of the Mini‐SIPS, a tool for early detection of individuals at clinical high risk and first episode of psychosis: A preliminary study of implementation in an Italian FEP program
Ferrara M, Basaldella M, Vacca F, Woods S, Walsh B, Cannon T, Srihari V, Grassi L. The Italian adaptation of the Mini‐SIPS, a tool for early detection of individuals at clinical high risk and first episode of psychosis: A preliminary study of implementation in an Italian FEP program. Early Intervention In Psychiatry 2024, 18: 1040-1046. PMID: 38769052, PMCID: PMC11625525, DOI: 10.1111/eip.13548.Peer-Reviewed Original ResearchClinical high riskFirst-episode psychosisDSM-5-Attenuated Psychosis SyndromeItalian adaptationPsychosis syndromeDSM-5FEP programsEarly stages of psychosisItalian versionFirst-episode psychosis servicesFull-blown psychosisStages of psychosisEpisode of psychosisClinical structured interviewEpisode psychosisEstablished psychosisTrained psychologistsPsychiatric historyPsychosisPsychosis servicesHigh riskStructured interviewsClinical settingEarly detection of individualsAssess validityAntipsychotic drugs in first-episode psychosis: a target trial emulation in the FEP-CAUSAL Collaboration
Szmulewicz A, Martínez-Alés G, Logan R, Ferrara M, Kelly C, Fredrikson D, Gago J, Conderino S, Díaz-Caneja C, Galvañ J, Thorpe L, Srihari V, Yatham L, Sarpal D, Shinn A, Arango C, Öngür D, Hernán M, Collaboration O. Antipsychotic drugs in first-episode psychosis: a target trial emulation in the FEP-CAUSAL Collaboration. American Journal Of Epidemiology 2024, 193: 1081-1087. PMID: 38576166, DOI: 10.1093/aje/kwae029.Peer-Reviewed Original ResearchFirst-episode psychosisFirst-generation agentsAntipsychotic therapyAntipsychotic drugsPsychosis onsetPsychotic disordersEpisode psychosisAripiprazolePaliperidoneRisk of hospitalizationPsychosisTarget trialsRisperidoneOlanzapineFirst-line therapyTreatment discontinuationEUFESTObservational cohortAntipsychoticsQuetiapineRandomized trialsPrimary outcomeAbsolute riskRisk differenceClinical questions
Clinical Trials
Current Trials
Study of Brain Function Across the Lifespan
HIC ID2000020891RoleSub InvestigatorPrimary Completion Date07/31/2022Recruiting ParticipantsGenderBothAge18 years - 65 years
Academic Achievements & Community Involvement
Clinical Care
Overview
Vinod H. Srihari, MD, is a psychiatrist dedicated to improving the outcomes of early course schizophrenia spectrum disorders. His clinical focus involves treating recent onset or 'first-episode' psychosis, often using a combination of medication management and psychosocial interventions designed to stabilize symptoms and promote long-term recovery.
Dr. Srihari also serves as director of the program for Specialized Treatment Early in Psychosis (STEP) at Yale. STEP includes a comprehensive early intervention service and hosts a statewide learning health system that aims to improve access and care for all individuals with recent onset schizophrenia spectrum disorders.
In addition to his clinical work, Dr. Srihari is an active researcher and professor of psychiatry at Yale School of Medicine. His research spans from studies of the causes and mechanisms of schizophrenia to innovative clinical interventions and service-level improvements aimed at enhancing patient outcomes. He is particularly interested in developing tools to help predict how a patient's condition might progress and how to choose the best treatments. He also works on interventions to prevent decline and promote recovery in early psychosis patients.
Dr. Srihari has been instrumental in developing and implementing an evidence-based medicine approach in psychiatric training. This approach enables psychiatrists in training to ask, access, appraise, and apply the best available scientific evidence to their practice, thereby improving patient care and population health.
Dr. Srihari received his medical training from the University of Rochester and completed his residency in psychiatry and a fellowship at Yale School of Medicine.
Clinical Specialties
Psychiatry
Fact Sheets
Schizophrenia
Learn More on Yale Medicine
Yale Medicine News
News & Links
Media
News
- March 19, 2025
Srihari Honored with SIRS 2025 Outstanding Clinical and Community Research Award
- February 11, 2025
Srihari Named Recipient of APA's Gralnick Award for Research in Schizophrenia
- February 13, 2024Source: WNPR
Mindmap 2.0 on Connecticut Public Radio
- February 13, 2024
Mindmap Launches Statewide Campaign to Support Early Detection of First-episode Psychosis in Teens and Young Adults
Get In Touch
Contacts
Mailing Address
Psychiatry
34 Park Street
New Haven, CT 06519
United States
Locations
The STEP Program
Lab
Connecticut Mental Health Center
34 Park Street
New Haven, CT 06519