Amber Howell
About
Research
Publications
2026
The Organization for Human Brain Mapping online Satellite meeting 2025: Enhancing accessibility and sustainability
Kalc P, Rae C, Tansey R, Wang M, Nieto N, Komeyer V, Patil K, Behler A, Breakspear M, Ren J, Okyere P, Li Z, Violante I, Liu H, Corsi M, Sorrentino P, Depannemaecker D, Duma G, Chen G, Cai Z, Vigotsky A, Abdallah C, Christensen E, Wheelock M, Kent J, Howell A, Michel L, Souter N, Hinault T. The Organization for Human Brain Mapping online Satellite meeting 2025: Enhancing accessibility and sustainability. Aperture Neuro 2026, 6 DOI: 10.52294/001c.158634.Peer-Reviewed Original Research
2025
Inferring intrinsic neural timescales using optimal control theory
Kim J, Betzel R, Beyh A, Howell A, Kuceyeski A, Larsen B, Seguin C, Zhang X, Holmes A, Parkes L. Inferring intrinsic neural timescales using optimal control theory. Nature Communications 2025, 16: 11639. PMID: 41298426, PMCID: PMC12748979, DOI: 10.1038/s41467-025-66542-w.Peer-Reviewed Original ResearchIntrinsic neural timescalesNetwork control theoryNeural timescalesNeurobiological measuresTemporal evolutionBrain regionsWhole-brain activityMeasures of cognitionFunctional neuroimaging dataBrain connectivityBrain structuresNeuroimaging dataIntrinsic dynamicsBrain statesTimescalesBrainBiophysical realismOptimal control theoryTheoryMeasurement of gene expressionDynamicsConnectomeNeurobiologyCognitionRegion124. Dynamic Structure-Function Coupling Across Intrinsic Brain States Reveals Links to Individual Cognitive and Behavioral Outcomes
Howell A, Cho Y, Murray J, Anticevic A, Lee K. 124. Dynamic Structure-Function Coupling Across Intrinsic Brain States Reveals Links to Individual Cognitive and Behavioral Outcomes. Biological Psychiatry 2025, 97: s146. DOI: 10.1016/j.biopsych.2025.02.361.Peer-Reviewed Original Research
2024
Functional Connectivity Biomarkers in Schizophrenia
Howell A, Anticevic A. Functional Connectivity Biomarkers in Schizophrenia. Advances In Neurobiology 2024, 40: 237-283. PMID: 39562448, DOI: 10.1007/978-3-031-69491-2_10.Peer-Reviewed Original ResearchConceptsFunctional connectivityResponse to antipsychotic medicationDebilitating neuropsychiatric disorderAbnormal brain functionFood and Drug AdministrationFunctional connectivity biomarkersAntipsychotic medicationNeural alterationsNeural changesPsychiatric conditionsNeuropsychiatric disordersNeural mechanismsBrain regionsSchizophreniaFC biomarkersNational Institutes of HealthConnectivity biomarkersBrain functionMagnetic resonance imaging (MRI)-based studyUS Food and Drug AdministrationFC metricsTreatment responseFDA-approved biomarkersPublic health problemPatient subgroupsOn the stability of canonical correlation analysis and partial least squares with application to brain-behavior associations
Helmer M, Warrington S, Mohammadi-Nejad A, Ji J, Howell A, Rosand B, Anticevic A, Sotiropoulos S, Murray J. On the stability of canonical correlation analysis and partial least squares with application to brain-behavior associations. Communications Biology 2024, 7: 217. PMID: 38383808, PMCID: PMC11245620, DOI: 10.1038/s42003-024-05869-4.Peer-Reviewed Original Research
2021
Schizophrenia and bipolar disorder are associated with opposite brain reward anticipation-associated response
Smucny J, Tully L, Howell A, Lesh T, Johnson S, OʼReilly R, Minzenberg M, Ursu S, Yoon J, Niendam T, Ragland J, Carter C. Schizophrenia and bipolar disorder are associated with opposite brain reward anticipation-associated response. Neuropsychopharmacology 2021, 46: 1152-1160. PMID: 33452432, PMCID: PMC8115687, DOI: 10.1038/s41386-020-00940-0.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum disordersBipolar disorderReward anticipationFeatures of schizophrenia spectrum disordersCore featuresHealthy controlsResponse to rewardNeurobiology of rewardNo effect of groupVentral striatal regionsType I BDFunctional correlatesEffect of groupReward processingAnterior insulaStriatal regionsRight insulaReward feedbackI BDT fMRISpectrum disorderInsulaRewardEngaging taskDisorders
2019
Extracellular free water and glutathione in first-episode psychosis—a multimodal investigation of an inflammatory model for psychosis
Lesh T, Maddock R, Howell A, Wang H, Tanase C, Daniel Ragland J, Niendam T, Carter C. Extracellular free water and glutathione in first-episode psychosis—a multimodal investigation of an inflammatory model for psychosis. Molecular Psychiatry 2019, 26: 761-771. PMID: 31138893, PMCID: PMC6881530, DOI: 10.1038/s41380-019-0428-y.Peer-Reviewed Original ResearchConceptsHealthy controlsMagnetic resonance imagingExtracellular free waterEtiology of psychotic disordersFirst-episode schizophreniaWhole brain greySiemens 3T scannerDiffusion MRI scansNo significant differenceVisual cortexBiomarkers of neuroinflammationPsychotic disordersInflammatory processBrain levelsSchizophreniaMRI scansInflammatory modelNeuroinflammatory biomarkersElevated FWPharmacological interventionsWhole-brainResonance imagingWhite matterSignificant differenceDiffusion magnetic resonance imaging
2017
Functional network changes and cognitive control in schizophrenia
Ray K, Lesh T, Howell A, Salo T, Ragland J, MacDonald A, Gold J, Silverstein S, Barch D, Carter C. Functional network changes and cognitive control in schizophrenia. NeuroImage Clinical 2017, 15: 161-170. PMID: 28529872, PMCID: PMC5429248, DOI: 10.1016/j.nicl.2017.05.001.Peer-Reviewed Original ResearchConceptsFrontal-parietal networkCognitive controlFunctional connectivityCognitive control deficitsEpisodic memory tasksHigher cognitive deficitsAssociated with diagnostic statusNetwork functional connectivityFunctional connectivity networksSchizophrenia patientsMemory taskFunctional network changesDiagnostic statusConnectivity deficitsCognitive deficitsParietal networkCognitive domainsBrain circuitryControl deficitsTask demandsNeural mechanismsBrain networksSchizophreniaNBS analysisAuditory network