Follow Your Heart
Vagal neurons represent gatekeepers in the neural regulation of cardiovascular functions, yet their physiological roles in health and disease remain elusive. We use AAV-guided anatomical mapping, in vivo calcium imaging, and optogenetics to genetically define and characterize vagal neurons that interact with the cardiovascular system.
You and Me, Heart Connected
A molecular and cellular dissection of neural circuits for diverse cardiovascular reflexes is a first step towards understanding the neural mechanisms of cardiovascular regulation. We use state-of- the-art genetic tools to establish a complete circuit-wiring paradigm for cardiovascular reflexes.
Deep into Your Brain
Sensory neurons in the circumventricular organs (CVOs) that lack a normal blood-brain barrier are excellent candidates for receiving body vital signals like hormones, electrolytes, and metabolites from the bloodstream. We use genetic approaches to functionally dissect sensory CVO neurons, with a focus on neuron types that control cardiovascular physiology.