Comparison of Outcomes with Midodrine and Fludrocortisone for Objective Recurrence in Treating Syncope (COMFORTS trial): Rationale and design for a multi-center randomized controlled trial
Aminorroaya A, Tavolinejad H, Sadeghian S, Jalali A, Alaeddini F, Emkanjoo Z, Mollazadeh R, Bozorgi A, Oraii S, Kiarsi M, Shahabi J, Akbarzadeh M, Rahimi B, Joharimoghadam A, Mohsenizade A, Mohammadi R, Oraii A, Ariannejad H, Apakuppakul S, Ngarmukos T, Tajdini M. Comparison of Outcomes with Midodrine and Fludrocortisone for Objective Recurrence in Treating Syncope (COMFORTS trial): Rationale and design for a multi-center randomized controlled trial. American Heart Journal 2021, 237: 5-12. PMID: 33689731, DOI: 10.1016/j.ahj.2021.03.002.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-1 Receptor AgonistsAnti-Inflammatory AgentsDrug Therapy, CombinationFludrocortisoneHumansMidodrineQuality of LifeRecurrenceSurveys and QuestionnairesSyncope, VasovagalTreatment OutcomeConceptsLifestyle modificationMulti-center randomized controlled trialQuality of lifeRandomized controlled trialsVasovagal syncopeCounter-pressure maneuversImprove QoLComparison of outcomesSecondary outcomesSyncopal episodesControlled trialsPrimary outcomeQoLRecurrence of vasovagal syncopeTrial backgroundAdverse drug reactionsSurvey questionnaireTreatment of vasovagal syncopeMinor adverse drug reactionsBackground of lifestyle modificationFollow-upCOMFORT trialsTreat syncopeMedicationOutcomes