Publications

• Artificial Intelligence-Enhanced Electrocardiogram Models for Detection of Left Ventricular Dysfunction: A Comparison Study.Croon PM, Boonstra MJ, Allaart CP, Arends BKO, Dhingra LS, Huang YC, Mast T, Khera R, Kuo CF, Kwon JM, Lee HS, Lee MS, van de Leur RR, Liu ZY, Oikonomou EK, Selder JL, Winter MM, Asselbergs FW. JACC Adv. 2026 Jan 20; 2026 Jan 20. PMID: 41564731.
• Using Machine Learning to Predict Adverse Events in Patients Undergoing Transcatheter Left Atrial Appendage Occlusion.Faridi KF, Mortazavi BJ, Huang S, Zimmerman S, Friedman DJ, Khera R, Krumholz HM, Curtis JP, Freeman JV. JACC Adv. 2026 Jan 20; 2026 Jan 20. PMID: 41564729.
• The OurHealth Study: A digital genomic cohort for cardiometabolic risk mechanisms in US South Asians.Ganesh S, Bhattacharya R, Bhatnagar A, Madnani R, Russo C, Haidermota S, Oruganty B, Bhavsar H, Shah P, Pitafi S, Uppal N, Sengupta N, Rice K, Conomos MP, Dave R, Khandelwal A, Patel AP, Paruchuri K, Levitsky Y, Parulkar SS, Khera R, Gulati M, Khera AV, Hornsby WE, Palaniappan L, Natarajan P. NPJ Digit Med. 2026 Jan 16; 2026 Jan 16. PMID: 41545632.
• DEVELOPMENT AND MULTINATIONAL VALIDATION OF ARTIFICIAL INTELLIGENCE-ENABLED ASCVD RISK STRATIFICATION USING ELECTROCARDIOGRAMS.Batinica B, Oikonomou EK, Pedroso AF, Aminorroaya A, Biswas D, Dhingra LS, Khera R. medRxiv. 2026 Jan 6; 2026 Jan 6. PMID: 41542668.
• Research Priorities and Future Directions in Cardio-Oncology.Mszar R, Ali A, Hull SC, Ferrucci LM, Baldassarre LA, Khera R, Irwin ML, Clasen SC. Curr Treat Options Oncol. 2026 Jan 4; 2026 Jan 4. PMID: 41484494.
• Artificial Intelligence Electrocardiogram Risk Tool-Reply.Dhingra LS, Aminorroaya A, Khera R. JAMA Cardiol. 2026 Jan 1. PMID: 41259010.
• Artificial Intelligence-Enabled Echocardiography as a Surrogate for Multimodality Aortic Stenosis Imaging: Post Hoc Analysis of a Clinical Trial.Oikonomou EK, Craig NJ, Holste G, Vasisht Shankar S, White A, Mahendran M, Newby DE, Dweck MR, Khera R. Circ Cardiovasc Imaging. 2025 Dec 31; 2025 Dec 31. PMID: 41473954.
• Evaluating the Accessibility of Transcatheter and Surgical Aortic Valve Replacement Across the US Via Driving-Times.Kapadia S, Shen M, Hanna J, Wheelock K, Pedroso AF, Vora A, Dhingra LS, Aminorroaya A, Khera R. Am J Cardiol. 2025 Dec 29; 2025 Dec 29. PMID: 41475454.
• Toward a Global Cardiovascular Mission Control: Reimagining Surveillance Through Artificial Intelligence and Digital Health.Khera R. J Am Coll Cardiol. 2025 Dec 2. PMID: 41298031.
• AI-Enabled Echocardiography Interpretation With Multitask Deep Learning-Reply.Holste G, Oikonomou EK, Khera R. JAMA. 2025 Dec 2. PMID: 41160035.
• Identifying Bias at Scale in Clinical Notes Using Large Language Models.Apakama DU, Nguyen KA, Hyppolite D, Soffer S, Mudrik A, Ling E, Moses A, Temnycky I, Glasser A, Anderson R, Parchure P, Woullard E, Edalati M, Chan L, Kronk C, Freeman R, Kia A, Timsina P, Levin MA, Khera R, Kovatch P, Charney AW, Carr BG, Richardson LD, Horowitz CR, Klang E, Nadkarni GN. Mayo Clin Proc Digit Health. 2025 Dec; 2025 Oct 14. PMID: 41334074.
• AI, Health, and Health Care Today and Tomorrow: The JAMA Summit Report on Artificial Intelligence.Angus DC, Khera R, Lieu T, Liu V, Ahmad FS, Anderson B, Bhavani SV, Bindman A, Brennan T, Celi LA, Chen F, Cohen IG, Denniston A, Desai S, Embí P, Faisal A, Ferryman K, Gerhart J, Gross M, Hernandez-Boussard T, Howell M, Johnson K, Lee K, Liu X, Lomis K, London AJ, Longhurst CA, Mandl KD, McGlynn E, Mello MM, Munoz F, Ohno-Machado L, Ouyang D, Perlis R, Phillips A, Rhew D, Ross JS, Saria S, Schwamm L, Seymour CW, Shah NH, Shah R, Singh K, Solomon M, Spates K, Spector-Bagdady K, Wang T, Gichoya JW, Weinstein J, Wiens J, Bibbins-Domingo K. JAMA. 2025 Nov 11. PMID: 41082366.
• Artificial Intelligence Across the JAMA Network: A Call for Submissions.Liu TYA, Hswen Y, Bonow RO, Carroll AE, Gross CP, Guterman EL, Khera R, Kibbe MR, Öngür D, Pirracchio R, Rotemberg V, Shew M, Shyr Y, Stuart EA, Bibbins-Domingo K, Perlis RH. JAMA. 2025 Nov 11. PMID: 41026475.
• Reliability of Artificial Intelligence-enhanced Electrocardiography.Dhingra LS, Croon PM, Batinica B, Aminorroaya A, Pedroso AF, Oikonomou EK, Khera R. medRxiv. 2025 Nov 6; 2025 Nov 6. PMID: 41282699.
• Phenotypic Selectivity of Artificial Intelligence-Enhanced Electrocardiography in Cardiovascular Diagnosis and Risk Prediction.Croon PM, Dhingra LS, Biswas D, Oikonomou EK, Khera R. Circulation. 2025 Nov 4; 2025 Sep 1. PMID: 40888124.
• Artificial Intelligence for Cardiovascular Care in Action: From Learning to Implementation in Health Systems.Biswas D, Thangaraj P, Pedroso AF, Ogunniyi MO, Maddox TM, Ahmad FS, Khera R. JACC Adv. 2025 Nov. PMID: 41350104.
• International Validation of Echocardiographic Artificial Intelligence Amyloid Detection Algorithm.Duffy G, Oikonomou EK, Easton N, Usuku H, Patel J, Katsumata Y, Yamasawa D, Stern L, Goto S, Tsujita K, Cheng P, Khera R, Ahmad FS, Ouyang D. JACC Adv. 2025 Nov; 2025 Sep 17. PMID: 40965401.
• TARGET-AI: a foundational approach for the targeted deployment of artificial intelligence electrocardiography in the electronic health record.Oikonomou EK, Batinica B, Dhingra LS, Aminorroaya A, Coppi A, Khera R. medRxiv. 2025 Oct 25; 2025 Oct 25. PMID: 40909833.
• Distributed Precision Stroke Care: Artificial Intelligence-Driven Stroke Management Using Multimodal Sensor Data.Pedroso AF, Schwamm LH, Khera R. Stroke. 2025 Oct 22; 2025 Oct 22. PMID: 41122835.
• AI in Adipose Imaging: Revolutionizing Visceral Adipose Tissue, Ectopic Fat, and Cardiovascular Risk Assessment.Kandi SR, Khera R, Rajagopalan S, Neeland IJ. Curr Atheroscler Rep. 2025 Oct 9; 2025 Oct 9. PMID: 41068345.
• National Patterns of Remote Patient Monitoring Service Availability at US Hospitals.Pedroso AF, Lin Z, Ross JS, Khera R. Circ Cardiovasc Qual Outcomes. 2025 Oct; 2025 Aug 19. PMID: 40827414.
• Scientific Writing in the Era of Large Language Models: A Computational Analysis of AI- Versus Human-Created Content.Khera R, Pedroso AF, Keloth VK, Xu H, Silva GS, Schwamm LH. Stroke. 2025 Oct; 2025 Aug 15. PMID: 40814778.
• Artificial intelligence-enabled electrocardiography and echocardiography to track preclinical progression of transthyretin amyloid cardiomyopathy.Oikonomou EK, Sangha V, Shankar SV, Coppi A, Krumholz HM, Nasir K, Miller EJ, Gallegos Kattan C, Al-Mallah MH, Al-Kindi S, Khera R. Eur Heart J. 2025 Oct 1. PMID: 40679604.
• Artificial Intelligence in the Management of Heart Failure.Cheema B, Hourmozdi J, Kline A, Ahmad F, Khera R. J Card Fail. 2025 Oct; 2025 May 7. PMID: 40345521.
• Evaluation of Care Quality for Atrial Fibrillation Across Non-Interoperable Electronic Health Record Data using a Retrieval-Augmented Generation-enabled Large Language Model.Adejumo P, Thangaraj PM, Dhingra LS, Biswas D, Aminorroaya A, Shankar SV, Pedroso AF, Croon PM, Khera R. medRxiv. 2025 Sep 24; 2025 Sep 24. PMID: 39371151.
• Access to electrophysiologic care for Medicare beneficiaries across the United States: Travel distance and time to nearest clinician, 2013-2020.Khaloo P, Wheelock KM, Hanna J, Kapadia S, Pedroso AF, Nabi W, Aminorroaya A, Freeman JV, Khera R. Heart Rhythm. 2025 Sep 9; 2025 Sep 9. PMID: 40935055.
• Transforming Population Health Screening for Atherosclerotic Cardiovascular Disease with AI-Enhanced ECG Analytics: Opportunities and Challenges.Biswas D, Aminorroaya A, Croon PM, Batinica B, Pedroso AF, Khera R. Curr Atheroscler Rep. 2025 Sep 1; 2025 Sep 1. PMID: 40888973.
• Update to the JACC Report Card: Excess Cardiovascular Mortality Among Black Americans, 2000-2023.Arun AS, Sawano M, Lu Y, Warner F, Caraballo C, Khera R, Echols MR, Yancy CW, Krumholz HM. J Am Coll Cardiol. 2025 Aug 26; 2025 Jun 19. PMID: 40835364.
• Phenotypic Selectivity of Artificial Intelligence-enhanced Electrocardiography in Cardiovascular Diagnosis and Risk Prediction.Croon PM, Dhingra LS, Biswas D, Oikonomou EK, Khera R. medRxiv. 2025 Aug 12; 2025 Aug 12. PMID: 40832396.
• Artificial intelligence-enhanced echocardiography in cardiovascular disease management.Myhre PL, Grenne B, Asch FM, Delgado V, Khera R, Lafitte S, Lang RM, Pellikka PA, Sengupta PP, Vemulapalli S, Lam CSP. Nat Rev Cardiol. 2025 Aug 5; 2025 Aug 5. PMID: 40764834.
• Changes in Cardiovascular Risk Factors and Health Care Expenditures Among Patients Prescribed Semaglutide.Lu Y, Liu Y, Totojani T, Kim C, Khera R, Xu H, Brush JE Jr, Krumholz HM, Abaluck J. JAMA Netw Open. 2025 Aug 1; 2025 Aug 1. PMID: 40779264.
• Artificial intelligence-guided point-of-care ultrasonography for cardiomyopathy detection - Authors' reply.Oikonomou EK, Khera R. Lancet Digit Health. 2025 Aug; 2025 Aug 6. PMID: 40769793.
• Identification of hypertrophic cardiomyopathy on electrocardiographic images with deep learning.Sangha V, Dhingra LS, Aminorroaya A, Croon PM, Sikand NV, Sen S, Martinez MW, Maron MS, Krumholz HM, Asselbergs FW, Oikonomou EK, Khera R. Nat Cardiovasc Res. 2025 Aug; 2025 Jul 22. PMID: 40696040.
• Risk of Thyroid Tumors With GLP-1 Receptor Agonists: A Retrospective Cohort Study.Morales DR, Bu F, Viernes B, DuVall SL, Matheny ME, Simon KR, Falconer T, Richter LR, Ostropolets A, Lau WCY, Man KKC, Chattopadhyay S, Mathioudakis N, Minty E, Nishimura A, Sun F, Yin C, Seager SL, Chai Y, Zhou JJ, Lu Y, Reyes C, Pistillo A, Duarte-Salles T, Blacketer C, Schuemie MJ, Ryan PB, Krumholz HM, Hripcsak G, Khera R, Suchard MA. Diabetes Care. 2025 Aug 1. PMID: 40465422.
• Nirmatrelvir-ritonavir versus placebo-ritonavir in individuals with long COVID in the USA (PAX LC): a double-blind, randomised, placebo-controlled, phase 2, decentralised trial.Sawano M, Bhattacharjee B, Caraballo C, Khera R, Li SX, Herrin J, Christian D, Coppi A, Warner F, Holub J, Henriquez Y, Johnson MA, Goddard TB, Rocco E, Hummel AC, Mouslmani MA, Hooper WB, Putrino DF, Carr KD, Charnas L, De Jesus M, Nepert D, Abreu P, Ziegler FW 3rd, Spertus JA, Iwasaki A, Krumholz HM. Lancet Infect Dis. 2025 Aug; 2025 Apr 3. PMID: 40188838.
• Complete AI-Enabled Echocardiography Interpretation With Multitask Deep Learning.Holste G, Oikonomou EK, Tokodi M, Kovács A, Wang Z, Khera R. JAMA. 2025 Jul 22. PMID: 40549400.
• Cardiac magnetic resonance markers of pre-clinical hypertrophic and dilated cardiomyopathy in genetic variant carriers.Croon PM, van Vugt M, Allaart CP, Ruijsink B, Elliott PM, Asselbergs FW, Khera R, Bezzina CR, Winter M, Schmidt AF. BMC Med. 2025 Jul 15; 2025 Jul 15. PMID: 40660250.
• Development and multinational validation of an ensemble deep learning algorithm for detecting and predicting structural heart disease using noisy single-lead electrocardiograms.Aminorroaya A, Dhingra LS, Pedroso AF, Shankar SV, Coppi A, Khunte A, Foppa M, Brant LCC, Barreto SM, Ribeiro ALP, Krumholz HM, Oikonomou EK, Khera R. Eur Heart J Digit Health. 2025 Jul; 2025 Apr 10. PMID: 40703117.
• Automated transformation of unstructured cardiovascular diagnostic reports into structured datasets using sequentially deployed large language models.Shankar SV, Dhingra LS, Aminorroaya A, Adejumo P, Nadkarni GN, Xu H, Brandt C, Oikonomou EK, Pedroso AF, Khera R. Eur Heart J Digit Health. 2025 Jul; 2025 Apr 2. PMID: 40703108.
• Towards a dynamic model to estimate evolving risk of major bleeding after percutaneous coronary intervention.Hurley NC, Desai N, Dhruva SS, Khera R, Schulz W, Huang C, Curtis J, Masoudi F, Rumsfeld J, Negahban S, Krumholz HM, Mortazavi BJ. PLOS Digit Health. 2025 Jun; 2025 Jun 25. PMID: 40560847.
• Wearable-Echo-FM: An ECG-echo foundation model for single lead electrocardiography.Knight E, Oikonomou EK, Aminorroaya A, Pedroso AF, Khera R. medRxiv. 2025 Jun 12; 2025 Jun 12. PMID: 40585148.
• The emerging role of AI in transforming cardiovascular care.Croon PM, Pedroso AF, Khera R. Future Cardiol. 2025 Jun; 2025 Apr 18. PMID: 40248957.
• Artificial Intelligence-Enabled Prediction of Heart Failure Risk From Single-Lead Electrocardiograms.Dhingra LS, Aminorroaya A, Pedroso AF, Khunte A, Sangha V, McIntyre D, Chow CK, Asselbergs FW, Brant LCC, Barreto SM, Ribeiro ALP, Krumholz HM, Oikonomou EK, Khera R. JAMA Cardiol. 2025 Jun 1. PMID: 40238120.
• Controversy in Hypertension: Pro-Side of the Argument Using Artificial Intelligence for Hypertension Diagnosis and Management.Armoundas AA, Ahmad FS, Attia ZI, Doudesis D, Khera R, Kyriakoulis KG, Stergiou GS, Tang WHW. Hypertension. 2025 Jun; 2025 Mar 17. PMID: 40091745.
• Internal Tremors and Vibrations in Long COVID: A Cross-Sectional Study.Zhou T, Sawano M, Arun AS, Caraballo C, Michelsen T, McAlpine LS, Bhattacharjee B, Lu Y, Khera R, Huang C, Warner F, Herrin J, Iwasaki A, Krumholz HM. Am J Med. 2025 Jun; 2024 Jul 26. PMID: 39069199.
• A Real-world Evaluation of Longitudinal Healthcare Expenses in a Health System Registry of Type-2 Diabetes Mellitus and Cardiovascular Disease Enabled by the 21st Century Cures Act.Dhingra LS, Pedroso AF, Aminorroaya A, Rajpura J, Mehanna S, Tonnu-Mihara I, Khera R. medRxiv. 2025 May 29; 2025 May 29. PMID: 40492070.
• Identification of Hypertrophic Cardiomyopathy on Electrocardiographic Images with Deep Learning.Sangha V, Dhingra LS, Aminorroaya A, Croon PM, Sikand NV, Sen S, Martinez MW, Maron MS, Krumholz HM, Asselbergs FW, Oikonomou EK, Khera R. medRxiv. 2025 May 28; 2025 May 28. PMID: 38234746.
• National Patterns of Remote Patient Monitoring Service Availability at US Hospitals.Pedroso AF, Lin Z, Ross JS, Khera R. medRxiv. 2025 May 27; 2025 May 27. PMID: 39484237.
• A Novel Sentence Transformer-based Natural Language Processing Approach for Schema Mapping of Electronic Health Records to the OMOP Common Data Model.Zhou X, Dhingra LS, Aminorroaya A, Adejumo P, Khera R. AMIA Annu Symp Proc. 2024; 2025 May 22. PMID: 40417570.
• Effects of Tirzepatide in Type 2 Diabetes: Individual Variation and Relationship to Cardiometabolic Outcomes.Aminorroaya A, Oikonomou EK, Biswas D, Jastreboff AM, Khera R. J Am Coll Cardiol. 2025 May 20; 2025 Mar 30. PMID: 40368575.
• Comparative Safety of Second-Line Antihyperglycemic Agents in Older Adults with Type 2 Diabetes: A Multinational Real-World Evidence From LEGEND-T2DM.Kim C, Bu F, Blacketer C, Ostropolets A, Duarte-Salles T, Viernes B, Falconer T, Pistillo A, Li J, Yin C, Van Zandt M, Nagy P, Nishimura A, Minty E, You SC, Sawano M, Sawano S, Jeon JY, Aminorroaya A, Dhingra LS, Pedroso AF, Thangraraj P, Dorr DA, Pratt N, Man KKC, Lau WCY, Morales DR, Khera R, Schuemie M, Ryan PB, Hripcsak G, Krumholz HM, Suchard MA, Lu Y. medRxiv. 2025 May 9; 2025 May 9. PMID: 40385382.
• From Pixels to Patterns: Radiomic Subphenotyping of Left Ventricular Hypertrophy on Echocardiography.Oikonomou EK, Khera R. Circ Cardiovasc Imaging. 2025 May; 2025 May 6. PMID: 40326361.
• Computational Phenomapping of Randomized Clinical Trial Participants to Enable Assessment of Their Real-World Representativeness and Personalized Inference.Thangaraj PM, Oikonomou EK, Dhingra LS, Aminorroaya A, Jayaram RH, Suchard MA, Khera R. Circ Cardiovasc Qual Outcomes. 2025 May; 2025 Apr 22. PMID: 40261065.
• Assessment of health conditions from patient electronic health record portals vs self-reported questionnaires: an analysis of the INSPIRE study.Khera R, Sawano M, Warner F, Coppi A, Pedroso AF, Spatz ES, Yu H, Gottlieb M, Saydah S, Stephens KA, Rising KL, Elmore JG, Hill MJ, Idris AH, Montoy JCC, O'Laughlin KN, Weinstein RA, Venkatesh A. J Am Med Inform Assoc. 2025 May 1. PMID: 40036551.
• The PAX LC Trial: A Decentralized, Phase 2, Randomized, Double-Blind Study of Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir for Long COVID.Krumholz HM, Sawano M, Bhattacharjee B, Caraballo C, Khera R, Li SX, Herrin J, Coppi A, Holub J, Henriquez Y, Johnson MA, Goddard TB, Rocco E, Hummel AC, Al Mouslmani M, Putrino DF, Carr KD, Carvajal-Gonzalez S, Charnas L, De Jesus M, Ziegler FW 3rd, Iwasaki A. Am J Med. 2025 May; 2024 May 10. PMID: 38735354.
• Artificial Intelligence-Based Automated Interpretation of Images of Electrocardiograms: Development and Multinational Validation of ECG-GPT.Khunte A, Sangha V, Oikonomou EK, Dhingra LS, Aminorroaya A, Coppi A, Shankar SV, Rockers E, Mortazavi BJ, Bhatt DL, Krumholz HM, Al-Kindi S, Nadkarni GN, Vaid A, Khera R. medRxiv. 2025 Apr 22; 2025 Apr 22. PMID: 38405776.
• PanEcho: Complete AI-enabled echocardiography interpretation with multi-task deep learning.Holste G, Oikonomou EK, Tokodi M, Kovács A, Wang Z, Khera R. medRxiv. 2025 Apr 16; 2025 Apr 16. PMID: 40321248.
• Use of Artificial Intelligence Applied to Electrocardiogram for Diagnosis of Left Ventricular Systolic Dysfunction.Santana Júnior WB, Pinto Filho MM, Barreto SM, Foppa M, Giatti L, Khera R, Ribeiro ALP. Arq Bras Cardiol. 2025 Apr. PMID: 40396866.
• Ensemble Deep Learning Algorithm for Structural Heart Disease Screening Using Electrocardiographic Images: PRESENT SHD.Dhingra LS, Aminorroaya A, Sangha V, Pedroso AF, Shankar SV, Coppi A, Foppa M, Brant LCC, Barreto SM, Ribeiro ALP, Krumholz HM, Oikonomou EK, Khera R. J Am Coll Cardiol. 2025 Apr 1. PMID: 40139886.
• Artificial Intelligence to Enhance Precision Medicine in Cardio-Oncology: A Scientific Statement From the American Heart Association.Khera R, Asnani AH, Krive J, Addison D, Zhu H, Vasbinder A, Fleming MR, Arnaout R, Razavi P, Okwuosa TM. Circ Genom Precis Med. 2025 Apr; 2025 Feb 24. PMID: 39989357.
• Predictors of Right Ventricular Pacing in Patients Undergoing Implantable Defibrillator Placement.Hummel JP, Lan Z, Jones PW, Khera R, Stein K, Curtis JP, Akar JG. J Cardiovasc Electrophysiol. 2025 Apr; 2025 Feb 10. PMID: 39930894.
• Artificial intelligence-enabled echocardiography as a surrogate for multi-modality aortic stenosis imaging: post-hoc analysis of a clinical trial.Oikonomou EK, Craig NJ, Holste G, Shankar SV, White A, Mahendran M, Newby DE, Dweck MR, Khera R. medRxiv. 2025 Mar 27; 2025 Mar 27. PMID: 40196287.
• Harnessing Artificial Intelligence for Innovation in Interventional Cardiovascular Care.Aminorroaya A, Biswas D, Pedroso AF, Khera R. J Soc Cardiovasc Angiogr Interv. 2025 Mar; 2025 Mar 18. PMID: 40230673.
• Heart failure risk stratification using artificial intelligence applied to electrocardiogram images: a multinational study.Dhingra LS, Aminorroaya A, Sangha V, Pedroso AF, Asselbergs FW, Brant LCC, Barreto SM, Ribeiro ALP, Krumholz HM, Oikonomou EK, Khera R. Eur Heart J. 2025 Mar 13. PMID: 39804243.
• Expanding artificial intelligence to understudied populations: congenital heart disease as the next frontier.Oikonomou EK, Khera R. Eur Heart J. 2025 Mar 3. PMID: 39523016.
• Significance of Coronary Artery Calcifications and Ischemic Electrocardiographic Changes Among Patients Undergoing Myocardial Perfusion Imaging.Kokkinidis DG, Kyriakoulis I, Chui PW, Agarwal R, Liu YH, Khera R, Sinusas AJ, Velazquez EJ, Miller EJ, Feher A. JACC Adv. 2025 Mar; 2025 Feb 20. PMID: 39983619.
• Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort study.Janetzki JL, Kim JH, Minty E, Lee JA, Morales DR, Khera R, Kim C, Alshammari TM, DuVall SL, Matheny ME, Falconer T, Kim S, Phan TP, Nguyen PA, Hsu MH, Hsu JC, Park RW, Man KKC, Seager S, Van Zandt M, Gilbert JP, Ryan PB, Schuemie MJ, Suchard MA, Hripcsak G, Pratt N, Chan You S. EClinicalMedicine. 2025 Mar; 2025 Feb 1. PMID: 39975698.
• Tracking the Preclinical Progression of Transthyretin Amyloid Cardiomyopathy Using Artificial Intelligence-Enabled Electrocardiography and Echocardiography.Oikonomou EK, Sangha V, Vasisht Shankar S, Coppi A, Krumholz HM, Nasir K, Miller EJ, Gallegos-Kattan C, Al-Mallah MH, Al-Kindi S, Khera R. medRxiv. 2025 Feb 24; 2025 Feb 24. PMID: 39252891.
• A Multicenter Evaluation of the Impact of Therapies on Deep Learning-Based Electrocardiographic Hypertrophic Cardiomyopathy Markers.Dhingra LS, Sangha V, Aminorroaya A, Bryde R, Gaballa A, Ali AH, Mehra N, Krumholz HM, Sen S, Kramer CM, Martinez MW, Desai MY, Oikonomou EK, Khera R. Am J Cardiol. 2025 Feb 15; 2024 Nov 23. PMID: 39581517.
• Artificial intelligence-guided detection of under-recognised cardiomyopathies on point-of-care cardiac ultrasonography: a multicentre study.Oikonomou EK, Vaid A, Holste G, Coppi A, McNamara RL, Baloescu C, Krumholz HM, Wang Z, Apakama DJ, Nadkarni GN, Khera R. Lancet Digit Health. 2025 Feb. PMID: 39890242.
• Evaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems.Aminorroaya A, Dhingra LS, Oikonomou EK, Khera R. Circ Genom Precis Med. 2025 Feb; 2025 Jan 23. PMID: 39846171.
• Validating International Classification of Diseases Code 10th Revision algorithms for accurate identification of pulmonary embolism.Bikdeli B, Khairani CD, Bejjani A, Lo YC, Mahajan S, Caraballo C, Jimenez JV, Krishnathasan D, Zarghami M, Rashedi S, Jimenez D, Barco S, Secemsky EA, Klok FA, Hunsaker AR, Aghayev A, Muriel A, Hussain MA, Appah-Sampong A, Lu Y, Lin Z, Mojibian H, Aneja S, Khera R, Konstantinides S, Goldhaber SZ, Wang L, Zhou L, Monreal M, Piazza G, Krumholz HM. J Thromb Haemost. 2025 Feb; 2024 Nov 4. PMID: 39505153.
• Computational Phenomapping of Randomized Clinical Trials to Enable Assessment of their Real-world Representativeness and Personalized Inference.Thangaraj PM, Oikonomou EK, Dhingra LS, Aminorroaya A, Jayaram R, Suchard MA, Khera R. medRxiv. 2025 Jan 24; 2025 Jan 24. PMID: 38798457.
• Leveraging AI-enhanced digital health with consumer devices for scalable cardiovascular screening, prediction, and monitoring.Pedroso AF, Khera R. NPJ Cardiovasc Health. 2025; 2025 Jul 2. PMID: 40620667.
• Automated Identification of Heart Failure With Reduced Ejection Fraction Using Deep Learning-Based Natural Language Processing.Nargesi AA, Adejumo P, Dhingra LS, Rosand B, Hengartner A, Coppi A, Benigeri S, Sen S, Ahmad T, Nadkarni GN, Lin Z, Ahmad FS, Krumholz HM, Khera R. JACC Heart Fail. 2025 Jan; 2024 Oct 23. PMID: 39453355.
• Artificial Intelligence-Enhanced Risk Stratification of Cancer Therapeutics-Related Cardiac Dysfunction Using Electrocardiographic Images.Oikonomou EK, Sangha V, Dhingra LS, Aminorroaya A, Coppi A, Krumholz HM, Baldassarre LA, Khera R. Circ Cardiovasc Qual Outcomes. 2025 Jan; 2024 Sep 2. PMID: 39221857.
• Designing medical artificial intelligence systems for global use: focus on interoperability, scalability, and accessibility.Oikonomou EK, Khera R. Hellenic J Cardiol. 2025 Jan-Feb; 2024 Jul 16. PMID: 39025234.
• Transforming Hypertension Diagnosis and Management in The Era of Artificial Intelligence: A 2023 National Heart, Lung, and Blood Institute (NHLBI) Workshop Report.Shimbo D, Shah RU, Abdalla M, Agarwal R, Ahmad FS, Anaya G, Attia ZI, Bull S, Chang AR, Commodore-Mensah Y, Ferdinand K, Kawamoto K, Khera R, Leopold J, Luo J, Makhni S, Mortazavi BJ, Oh YS, Savage LC, Spatz ES, Stergiou G, Turakhia MP, Whelton PK, Yancy CW, Iturriaga E. Hypertension. 2025 Jan; 2024 Jul 16. PMID: 39011653.
• An Ensemble Deep Learning Algorithm for Structural Heart Disease Screening Using Electrocardiographic Images: PRESENT SHD.Dhingra LS, Aminorroaya A, Sangha V, Pedroso AF, Shankar SV, Coppi A, Foppa M, Brant LC, Barreto SM, Ribeiro ALP, Krumholz HM, Oikonomou EK, Khera R. medRxiv. 2024 Dec 27; 2024 Dec 27. PMID: 39417095.
• Artificial Intelligence Enabled Prediction of Heart Failure Risk from Single-lead Electrocardiograms.Dhingra LS, Aminorroaya A, Pedroso AF, Khunte A, Sangha V, McIntyre D, Chow CK, Asselbergs FW, Brant LC, Barreto SM, Ribeiro ALP, Krumholz HM, Oikonomou EK, Khera R. medRxiv. 2024 Dec 21; 2024 Dec 21. PMID: 38854022.
• International Validation of Echocardiographic AI Amyloid Detection Algorithm.Duffy G, Oikonomou E, Hourmozdi J, Usuku H, Patel J, Stern L, Goto S, Tsujita K, Khera R, Ahmad FS, Ouyang D. medRxiv. 2024 Dec 16; 2024 Dec 16. PMID: 39763545.
• Artificial Intelligence Applications for Electrocardiography to Define New Digital Biomarkers of Cardiovascular Risk.Sangha V, Khera R. Circ Cardiovasc Qual Outcomes. 2024 Dec; 2024 Nov 14. PMID: 39540286.
• Cardiovascular care with digital twin technology in the era of generative artificial intelligence.Thangaraj PM, Benson SH, Oikonomou EK, Asselbergs FW, Khera R. Eur Heart J. 2024 Dec 1. PMID: 39322420.
• Cardiac magnetic resonance markers of pre-clinical hypertrophic and dilated cardiomyopathy in genetic variant carriers.Croon PM, van Vugt M, Allaart CP, Ruijsink B, Elliott PM, Asselbergs FW, Khera R, Bezzina CR, Winter M, Schmidt AF. medRxiv. 2024 Nov 18; 2024 Nov 18. PMID: 39606349.
• Impact of the COVID-19 pandemic on hospital-based heart failure care in New South Wales, Australia: a linked data cohort study.McIntyre D, Quintans D, Kazi S, Min H, He WQ, Marschner S, Khera R, Nassar N, Chow CK. BMC Health Serv Res. 2024 Nov 8; 2024 Nov 8. PMID: 39516863.
• Natural Language Processing of Clinical Documentation to Assess Functional Status in Patients With Heart Failure.Adejumo P, Thangaraj PM, Dhingra LS, Aminorroaya A, Zhou X, Brandt C, Xu H, Krumholz HM, Khera R. JAMA Netw Open. 2024 Nov 4; 2024 Nov 4. PMID: 39509128.
• Development and Multinational Validation of an Ensemble Deep Learning Algorithm for Detecting and Predicting Structural Heart Disease Using Noisy Single-lead Electrocardiograms.Aminorroaya A, Dhingra LS, Pedroso Camargos A, Vasisht Shankar S, Coppi A, Khunte A, Foppa M, Brant LC, Barreto SM, Ribeiro ALP, Krumholz HM, Oikonomou EK, Khera R. medRxiv. 2024 Oct 8; 2024 Oct 8. PMID: 39417103.
• Automated Transformation of Unstructured Cardiovascular Diagnostic Reports into Structured Datasets Using Sequentially Deployed Large Language Models.Shankar SV, Dhingra LS, Aminorroaya A, Adejumo P, Nadkarni GN, Xu H, Brandt C, Oikonomou EK, Pedroso AF, Khera R. medRxiv. 2024 Oct 8; 2024 Oct 8. PMID: 39417094.
• Racial and Ethnic Disparities in Age-Specific All-Cause Mortality During the COVID-19 Pandemic.Faust JS, Renton B, Bongiovanni T, Chen AJ, Sheares KD, Du C, Essien UR, Fuentes-Afflick E, Haywood T, Khera R, King T, Li SX, Lin Z, Lu Y, Marshall ADA, Ndumele CD, Opara I, Loarte-Rodriguez T, Sawano M, Taparra K, Taylor HA, Watson KE, Yancy CW, Krumholz HM. JAMA Netw Open. 2024 Oct 1; 2024 Oct 1. PMID: 39392630.
• Reviewer Experience Detecting and Judging Human Versus Artificial Intelligence Content: The Stroke Journal Essay Contest.Silva GS, Khera R, Schwamm LH. Stroke. 2024 Oct; 2024 Sep 3. PMID: 39224979.
• Artificial intelligence-enhanced patient evaluation: bridging art and science.Oikonomou EK, Khera R. Eur Heart J. 2024 Sep 14. PMID: 38976371.
• A Novel Digital Twin Strategy to Examine the Implications of Randomized Clinical Trials for Real-World Populations.Thangaraj PM, Shankar SV, Huang S, Nadkarni GN, Mortazavi BJ, Oikonomou EK, Khera R. medRxiv. 2024 Sep 6; 2024 Sep 6. PMID: 38585929.
• Cause-Specific Mortality Rates Among the US Black Population.Arun AS, Caraballo C, Sawano M, Lu Y, Khera R, Yancy CW, Krumholz HM. JAMA Netw Open. 2024 Sep 3; 2024 Sep 3. PMID: 39348122.
• Comparative Effectiveness of Second-Line Antihyperglycemic Agents for Cardiovascular Outcomes: A Multinational, Federated Analysis of LEGEND-T2DM.Khera R, Aminorroaya A, Dhingra LS, Thangaraj PM, Pedroso Camargos A, Bu F, Ding X, Nishimura A, Anand TV, Arshad F, Blacketer C, Chai Y, Chattopadhyay S, Cook M, Dorr DA, Duarte-Salles T, DuVall SL, Falconer T, French TE, Hanchrow EE, Kaur G, Lau WCY, Li J, Li K, Liu Y, Lu Y, Man KKC, Matheny ME, Mathioudakis N, McLeggon JA, McLemore MF, Minty E, Morales DR, Nagy P, Ostropolets A, Pistillo A, Phan TP, Pratt N, Reyes C, Richter L, Ross JS, Ruan E, Seager SL, Simon KR, Viernes B, Yang J, Yin C, You SC, Zhou JJ, Ryan PB, Schuemie MJ, Krumholz HM, Hripcsak G, Suchard MA. J Am Coll Cardiol. 2024 Sep 3. PMID: 39197980.
• Correlation between hospital rates of survival to discharge and long-term survival for in-hospital cardiac arrest: Insights from Get With The Guidelines®-Resuscitation registry.Khera R, Aminorroaya A, Kennedy KF, Chan PS. Resuscitation. 2024 Sep; 2024 Jul 18. PMID: 39029583.
• Local large language models for privacy-preserving accelerated review of historic echocardiogram reports.Vaid A, Duong SQ, Lampert J, Kovatch P, Freeman R, Argulian E, Croft L, Lerakis S, Goldman M, Khera R, Nadkarni GN. J Am Med Inform Assoc. 2024 Sep 1. PMID: 38687616.
• Multimodal fusion learning for long QT syndrome pathogenic genotypes in a racially diverse population.Jiang J, Thi Vy HM, Charney A, Kovatch P, Reddy V, Jayaraman P, Do R, Khera R, Chugh S, Bhatt DL, Vaid A, Lampert J, Nadkarni GN. NPJ Digit Med. 2024 Aug 24; 2024 Aug 24. PMID: 39181999.
• AI-enabled diagnosis from an electrocardiogram image: the next frontier of innovation in a century-old technology.Khera R. Heart. 2024 Aug 14; 2024 Aug 14. PMID: 39048290.
• Excess Cardiovascular Mortality Among Black Americans 2000-2022.Arun AS, Sawano M, Lu Y, Warner F, Caraballo C, Khera R, Echols MR, Yancy CW, Krumholz HM. J Am Coll Cardiol. 2024 Aug 6; 2024 Jun 18. PMID: 38901531.
• Video-Based Kinematic Analysis of Movement Quality in a Phase 3 Clinical Trial of Troriluzole in Adults with Spinocerebellar Ataxia: A Post Hoc Analysis.L'Italien GJ, Oikonomou EK, Khera R, Potashman MH, Beiner MW, Maclaine GDH, Schmahmann JD, Perlman S, Coric V. Neurol Ther. 2024 Aug; 2024 May 30. PMID: 38814532.