2022
Clinical Associations of Injuries Caused by Vasovagal Syncope: A Cohort Study From a Tertiary Syncope Unit
Tajdini M, Tavolinejad H, Aminorroaya A, Aryan Z, Jalali A, Alaeddini F, Sadeghian S, Yadangi S, Vasheghani‐Farahani A, Kalhor P, Bozorgi A. Clinical Associations of Injuries Caused by Vasovagal Syncope: A Cohort Study From a Tertiary Syncope Unit. Journal Of The American Heart Association 2022, 12: e027272. PMID: 36565190, PMCID: PMC9973565, DOI: 10.1161/jaha.122.027272.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesFemaleHumansMaleMiddle AgedProspective StudiesSyncopeSyncope, VasovagalTilt-Table TestConceptsAssociation of injuryIncidence of injuryAssociated with injuryVasovagal syncopeClinical associationsRate of injuryAssociated with lower riskRisk of injuryAt-risk individualsAbsence of prodromesRecurrent vasovagal syncopeYears of ageStanding positionCohort studySyncope clinicHigh-risk situationsRecurrent casesFemale sexProspective studyPatient characteristicsClinical evaluationSyncopeSyncope unitLow riskInjuryPharmacologic prevention of recurrent vasovagal syncope: A systematic review and network meta-analysis of randomized controlled trials
Behnoush A, Yazdani K, Khalaji A, Tavolinejad H, Aminorroaya A, Jalali A, Tajdini M. Pharmacologic prevention of recurrent vasovagal syncope: A systematic review and network meta-analysis of randomized controlled trials. Heart Rhythm 2022, 20: 448-460. PMID: 36509319, DOI: 10.1016/j.hrthm.2022.12.010.Peer-Reviewed Original ResearchMeSH KeywordsFluoxetineHumansMidodrineNetwork Meta-AnalysisRandomized Controlled Trials as TopicSyncope, VasovagalConceptsHead-up tilt testPositive head-up tilt testNetwork meta-analysisRandomized controlled trialsVasovagal syncopeMeta-analysisPharmacological therapyPrimary outcomeRisk ratioRandom-effects network meta-analysisSystematic reviewPooled risk ratioConfidence intervalsHealth care systemLevel of evidenceCumulative ranking curve analysisPairwise meta-analysisTreatment optionsWeb of ScienceSyncopal eventsTilt testCare systemComparative efficacySecondary outcomesCochrane LibraryCompression stockings for treating vasovagal syncope (COMFORTS-II) trial: Rationale and design of a triple-blind, multi-center, randomized controlled trial
Tavolinejad H, Poopak A, Sadeghian S, Bozorgi A, Oraii A, Mollazadeh R, Emkanjoo Z, Kiarsi M, Shahabi J, Jalali A, Alaeddini F, Ariannejad H, Yadangi S, Oraii S, Kheirkhah J, Assadianrad M, Aminorroaya A, Tajdini M. Compression stockings for treating vasovagal syncope (COMFORTS-II) trial: Rationale and design of a triple-blind, multi-center, randomized controlled trial. American Heart Journal 2022, 249: 57-65. PMID: 35405100, DOI: 10.1016/j.ahj.2022.04.002.Peer-Reviewed Original ResearchConceptsElastic compression stockingsRandomized controlled trialsVasovagal syncopeProportion of participantsCompression stockingsTriple-blindLifestyle modification recommendationsVenous returnCo-primary outcomesPatient-reported adverse effectsTreat vasovagal syncopeVasovagal syncope recurrencesDiary sheetsSecondary outcomesStudy armsReduced venous returnSyncope recurrenceTrial backgroundSyncopal episodesFollow-upClinical trialsParticipantsMulti-centerOnline randomizationRecurrence
2021
Comparison of Outcomes with Midodrine and Fludrocortisone for Objective Recurrence in Treating Syncope (COMFORTS trial): Rationale and design for a multi-center randomized controlled trial
Aminorroaya A, Tavolinejad H, Sadeghian S, Jalali A, Alaeddini F, Emkanjoo Z, Mollazadeh R, Bozorgi A, Oraii S, Kiarsi M, Shahabi J, Akbarzadeh M, Rahimi B, Joharimoghadam A, Mohsenizade A, Mohammadi R, Oraii A, Ariannejad H, Apakuppakul S, Ngarmukos T, Tajdini M. Comparison of Outcomes with Midodrine and Fludrocortisone for Objective Recurrence in Treating Syncope (COMFORTS trial): Rationale and design for a multi-center randomized controlled trial. American Heart Journal 2021, 237: 5-12. PMID: 33689731, DOI: 10.1016/j.ahj.2021.03.002.Peer-Reviewed Original ResearchConceptsLifestyle modificationMulti-center randomized controlled trialQuality of lifeRandomized controlled trialsVasovagal syncopeCounter-pressure maneuversImprove QoLComparison of outcomesSecondary outcomesSyncopal episodesControlled trialsPrimary outcomeQoLRecurrence of vasovagal syncopeTrial backgroundAdverse drug reactionsSurvey questionnaireTreatment of vasovagal syncopeMinor adverse drug reactionsBackground of lifestyle modificationFollow-upCOMFORT trialsTreat syncopeMedicationOutcomes
2020
Comparison of trinitroglycerin and adenosine as provocative agents for head-up tilt test in patients with unexplained syncope: a semi-crossover randomized clinical trial with prospective follow-up
Tajdini M, Aminorroaya A, Rahimi B, Mortazavi S, Vasheghani Farahani A, Sadeghian S, Easapour Moghadam M, Soltani D, Bozorgi A. Comparison of trinitroglycerin and adenosine as provocative agents for head-up tilt test in patients with unexplained syncope: a semi-crossover randomized clinical trial with prospective follow-up. Journal Of Interventional Cardiac Electrophysiology 2020, 60: 31-39. PMID: 31907833, DOI: 10.1007/s10840-019-00652-6.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineFemaleFollow-Up StudiesHumansMaleNitroglycerinProspective StudiesSyncopeSyncope, VasovagalTilt-Table TestConceptsTransient loss of consciousnessFollow-upUnexplained syncopeProvocative agentsTilt testDiagnostic evaluationPositive response to HUTTHead-up tilt testResponse to HUTTSuspected vasovagal syncopeRandomized clinical trialsDiagnosis of unexplained syncopeStatistically significant differenceDiagnostic yieldLoss of consciousnessRandomized patientsEvaluating patientsVasovagal syncopeVasovagal responseClinical trialsIntravenous ADPatientsSyncopeTrinitroglycerinRe-admission