Toll-like receptor 7 regulates cardiovascular diseases
Shafeghat M, Kazemian S, Aminorroaya A, Aryan Z, Rezaei N. Toll-like receptor 7 regulates cardiovascular diseases. International Immunopharmacology 2022, 113: 109390. PMID: 36330918, DOI: 10.1016/j.intimp.2022.109390.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesEndothelial CellsHumansSignal TransductionToll-Like Receptor 7Toll-Like Receptor 9Toll-Like ReceptorsTumor Necrosis Factor-alphaConceptsTLR-7Toll-like receptorsIncreased risk of complete heart blockRisk of complete heart blockGranulocyte-macrophage colony-stimulating factorTLR-7 activationTLR-7 ligandsVascular smooth muscle cellsComplete heart blockImmune system's roleLeft ventricular remodelingColony-stimulating factorDamage-associated molecular patternsSmooth muscle cellsInnate immune receptorsPro-inflammatory natureRisk of thrombus formationHeart blockImmune cellsVentricular remodelingIncreased riskMuscle cellsAtherosclerotic plaque formationSingle-stranded ribonucleic acidViral infection