2022
Clinical Associations of Injuries Caused by Vasovagal Syncope: A Cohort Study From a Tertiary Syncope Unit
Tajdini M, Tavolinejad H, Aminorroaya A, Aryan Z, Jalali A, Alaeddini F, Sadeghian S, Yadangi S, Vasheghani‐Farahani A, Kalhor P, Bozorgi A. Clinical Associations of Injuries Caused by Vasovagal Syncope: A Cohort Study From a Tertiary Syncope Unit. Journal Of The American Heart Association 2022, 12: e027272. PMID: 36565190, PMCID: PMC9973565, DOI: 10.1161/jaha.122.027272.Peer-Reviewed Original ResearchConceptsAssociation of injuryIncidence of injuryAssociated with injuryVasovagal syncopeClinical associationsRate of injuryAssociated with lower riskRisk of injuryAt-risk individualsAbsence of prodromesRecurrent vasovagal syncopeYears of ageStanding positionCohort studySyncope clinicHigh-risk situationsRecurrent casesFemale sexProspective studyPatient characteristicsClinical evaluationSyncopeSyncope unitLow riskInjuryPharmacologic prevention of recurrent vasovagal syncope: A systematic review and network meta-analysis of randomized controlled trials
Behnoush A, Yazdani K, Khalaji A, Tavolinejad H, Aminorroaya A, Jalali A, Tajdini M. Pharmacologic prevention of recurrent vasovagal syncope: A systematic review and network meta-analysis of randomized controlled trials. Heart Rhythm 2022, 20: 448-460. PMID: 36509319, DOI: 10.1016/j.hrthm.2022.12.010.Peer-Reviewed Original ResearchConceptsHead-up tilt testPositive head-up tilt testNetwork meta-analysisRandomized controlled trialsVasovagal syncopeMeta-analysisPharmacological therapyPrimary outcomeRisk ratioRandom-effects network meta-analysisSystematic reviewPooled risk ratioConfidence intervalsHealth care systemLevel of evidenceCumulative ranking curve analysisPairwise meta-analysisTreatment optionsWeb of ScienceSyncopal eventsTilt testCare systemComparative efficacySecondary outcomesCochrane LibraryCompression stockings for treating vasovagal syncope (COMFORTS-II) trial: Rationale and design of a triple-blind, multi-center, randomized controlled trial
Tavolinejad H, Poopak A, Sadeghian S, Bozorgi A, Oraii A, Mollazadeh R, Emkanjoo Z, Kiarsi M, Shahabi J, Jalali A, Alaeddini F, Ariannejad H, Yadangi S, Oraii S, Kheirkhah J, Assadianrad M, Aminorroaya A, Tajdini M. Compression stockings for treating vasovagal syncope (COMFORTS-II) trial: Rationale and design of a triple-blind, multi-center, randomized controlled trial. American Heart Journal 2022, 249: 57-65. PMID: 35405100, DOI: 10.1016/j.ahj.2022.04.002.Peer-Reviewed Original ResearchConceptsElastic compression stockingsRandomized controlled trialsVasovagal syncopeProportion of participantsCompression stockingsTriple-blindLifestyle modification recommendationsVenous returnCo-primary outcomesPatient-reported adverse effectsTreat vasovagal syncopeVasovagal syncope recurrencesDiary sheetsSecondary outcomesStudy armsReduced venous returnSyncope recurrenceTrial backgroundSyncopal episodesFollow-upClinical trialsParticipantsMulti-centerOnline randomizationRecurrence
2021
Association of folate and vitamin B12 deficiency with vasovagal syncope: a case-control study
Aminorroaya A, Tajdini M, Yunesian M, Boroumand M, Tavolinejad H, Yadangi S, Sadeghian S, Bozorgi A, Jalali A, Vasheghani-Farahani A. Association of folate and vitamin B12 deficiency with vasovagal syncope: a case-control study. European Heart Journal 2021, 42: ehab724.0621. DOI: 10.1093/eurheartj/ehab724.0621.Peer-Reviewed Original ResearchThyroid-stimulating hormoneVitamin B12 deficiencyLevels of vitamin B12Serum levels of vitamin B12Head-up tilt testAssociation of folateB12 deficiencyVasovagal syncopeSerum levelsVitamin B12Adult patientsSyncopal episodesLogistic regression modelsPlasma levels of vitamin B12Control groupHistory of bariatric surgeryHealthy individualsPrevalence of folateDiagnosis of vasovagal syncopeHistory of syncopePopulation-based cohort studyRecurrent vasovagal syncopeChi-square and t-testsDeficiency of folateSerum vitamin B12Atomoxetine as an adjunct to nonpharmacological treatments for preventing vasovagal attacks in patients with recurrent vasovagal syncope: A pilot randomized-controlled trial
Tajdini M, Aminorroaya A, Tavolinejad H, Tofighi S, Jalali A, Sadeghian S, Vasheghani-Farahani A, Yadangi S, Shahmansouri N, Akhondzadeh S, Bozorgi A. Atomoxetine as an adjunct to nonpharmacological treatments for preventing vasovagal attacks in patients with recurrent vasovagal syncope: A pilot randomized-controlled trial. IJC Heart & Vasculature 2021, 34: 100789. PMID: 34027030, PMCID: PMC8129927, DOI: 10.1016/j.ijcha.2021.100789.Peer-Reviewed Original ResearchPre-syncopal episodesRecurrent vasovagal syncopeVasovagal syncopeEffects of atomoxetinePrimary endpointPlacebo groupMedian timeSubgroup analysis of patientsPre-syncopal attackNorepinephrine reuptake inhibitionPlacebo-controlled trialAnalysis of patientsPharmacological treatment optionsSystolic blood pressureDiagnosed VVSSyncope/pre-syncopeReduced quality of lifeReuptake inhibitionRandomized patientsAtomoxetine groupSyncopal episodesVasovagal attackTreatment optionsSubgroup analysisRandomized trialsComparison of Outcomes with Midodrine and Fludrocortisone for Objective Recurrence in Treating Syncope (COMFORTS trial): Rationale and design for a multi-center randomized controlled trial
Aminorroaya A, Tavolinejad H, Sadeghian S, Jalali A, Alaeddini F, Emkanjoo Z, Mollazadeh R, Bozorgi A, Oraii S, Kiarsi M, Shahabi J, Akbarzadeh M, Rahimi B, Joharimoghadam A, Mohsenizade A, Mohammadi R, Oraii A, Ariannejad H, Apakuppakul S, Ngarmukos T, Tajdini M. Comparison of Outcomes with Midodrine and Fludrocortisone for Objective Recurrence in Treating Syncope (COMFORTS trial): Rationale and design for a multi-center randomized controlled trial. American Heart Journal 2021, 237: 5-12. PMID: 33689731, DOI: 10.1016/j.ahj.2021.03.002.Peer-Reviewed Original ResearchConceptsLifestyle modificationMulti-center randomized controlled trialQuality of lifeRandomized controlled trialsVasovagal syncopeCounter-pressure maneuversImprove QoLComparison of outcomesSecondary outcomesSyncopal episodesControlled trialsPrimary outcomeQoLRecurrence of vasovagal syncopeTrial backgroundAdverse drug reactionsSurvey questionnaireTreatment of vasovagal syncopeMinor adverse drug reactionsBackground of lifestyle modificationFollow-upCOMFORT trialsTreat syncopeMedicationOutcomes
2020
Atomoxetine in patients with recurrent vasovagal syncope for preventing vasovagal attacks and improvement of depression and anxiety: a randomized double-blind placebo-controlled clinical trial
Tajdini M, Aminorroaya A, Tavolinejad H, Tofighi S, Jalali A, Sadeghian S, Akhondzadeh S, Vasheghani-Farahani A, Yadangi S, Shahmansouri N, Bozorgi A. Atomoxetine in patients with recurrent vasovagal syncope for preventing vasovagal attacks and improvement of depression and anxiety: a randomized double-blind placebo-controlled clinical trial. European Heart Journal 2020, 41: ehaa946.0713. DOI: 10.1093/ehjci/ehaa946.0713.Peer-Reviewed Original ResearchPre-syncopal episodesImprove anxietyRecurrent vasovagal syncopeVasovagal syncopeEffects of atomoxetineSyncopal episodesImprovement of depressionPrimary endpointSignificant between-subjects effectAbstract Background StudiesHospital Anxiety and Depression ScaleAnxiety and Depression ScaleDouble-blind placebo-controlled randomized clinical trialPlacebo-controlled randomized clinical trialBetween-subject effectsPreventing recurrence of syncopeMonths of follow-upAtomoxetineCompared to placeboDepression scoresRecurrence of syncopeAnxietyDepressionDepression ScaleMann-Whitney U testComparison of trinitroglycerin and adenosine as provocative agents for head-up tilt test in patients with unexplained syncope: a semi-crossover randomized clinical trial with prospective follow-up
Tajdini M, Aminorroaya A, Rahimi B, Mortazavi S, Vasheghani Farahani A, Sadeghian S, Easapour Moghadam M, Soltani D, Bozorgi A. Comparison of trinitroglycerin and adenosine as provocative agents for head-up tilt test in patients with unexplained syncope: a semi-crossover randomized clinical trial with prospective follow-up. Journal Of Interventional Cardiac Electrophysiology 2020, 60: 31-39. PMID: 31907833, DOI: 10.1007/s10840-019-00652-6.Peer-Reviewed Original ResearchConceptsTransient loss of consciousnessFollow-upUnexplained syncopeProvocative agentsTilt testDiagnostic evaluationPositive response to HUTTHead-up tilt testResponse to HUTTSuspected vasovagal syncopeRandomized clinical trialsDiagnosis of unexplained syncopeStatistically significant differenceDiagnostic yieldLoss of consciousnessRandomized patientsEvaluating patientsVasovagal syncopeVasovagal responseClinical trialsIntravenous ADPatientsSyncopeTrinitroglycerinRe-admission