Compression stockings for treating vasovagal syncope (COMFORTS-II) trial: Rationale and design of a triple-blind, multi-center, randomized controlled trial
Tavolinejad H, Poopak A, Sadeghian S, Bozorgi A, Oraii A, Mollazadeh R, Emkanjoo Z, Kiarsi M, Shahabi J, Jalali A, Alaeddini F, Ariannejad H, Yadangi S, Oraii S, Kheirkhah J, Assadianrad M, Aminorroaya A, Tajdini M. Compression stockings for treating vasovagal syncope (COMFORTS-II) trial: Rationale and design of a triple-blind, multi-center, randomized controlled trial. American Heart Journal 2022, 249: 57-65. PMID: 35405100, DOI: 10.1016/j.ahj.2022.04.002.Peer-Reviewed Original ResearchConceptsElastic compression stockingsRandomized controlled trialsVasovagal syncopeProportion of participantsCompression stockingsTriple-blindLifestyle modification recommendationsVenous returnCo-primary outcomesPatient-reported adverse effectsTreat vasovagal syncopeVasovagal syncope recurrencesDiary sheetsSecondary outcomesStudy armsReduced venous returnSyncope recurrenceTrial backgroundSyncopal episodesFollow-upClinical trialsParticipantsMulti-centerOnline randomizationRecurrence