2024
Comparative Effectiveness of Second-Line Antihyperglycemic Agents for Cardiovascular Outcomes A Multinational, Federated Analysis of LEGEND-T2DM
Khera R, Aminorroaya A, Dhingra L, Thangaraj P, Pedroso Camargos A, Bu F, Ding X, Nishimura A, Anand T, Arshad F, Blacketer C, Chai Y, Chattopadhyay S, Cook M, Dorr D, Duarte-Salles T, DuVall S, Falconer T, French T, Hanchrow E, Kaur G, Lau W, Li J, Li K, Liu Y, Lu Y, Man K, Matheny M, Mathioudakis N, McLeggon J, McLemore M, Minty E, Morales D, Nagy P, Ostropolets A, Pistillo A, Phan T, Pratt N, Reyes C, Richter L, Ross J, Ruan E, Seager S, Simon K, Viernes B, Yang J, Yin C, You S, Zhou J, Ryan P, Schuemie M, Krumholz H, Hripcsak G, Suchard M. Comparative Effectiveness of Second-Line Antihyperglycemic Agents for Cardiovascular Outcomes A Multinational, Federated Analysis of LEGEND-T2DM. Journal Of The American College Of Cardiology 2024, 84: 904-917. PMID: 39197980, DOI: 10.1016/j.jacc.2024.05.069.Peer-Reviewed Original ResearchConceptsGLP-1 RAsSecond-line agentsGLP-1Antihyperglycemic agentsCardiovascular diseaseMACE riskGlucagon-like peptide-1 receptor agonistsSodium-glucose cotransporter 2 inhibitorsPeptide-1 receptor agonistsDipeptidyl peptidase-4 inhibitorsEffects of SGLT2isType 2 diabetes mellitusPeptidase-4 inhibitorsAdverse cardiovascular eventsCox proportional hazards modelsRandom-effects meta-analysisCardiovascular risk reductionTarget trial emulationProportional hazards modelPerformance of contemporary cardiovascular risk stratification scores in Brazil: an evaluation in the ELSA-Brasil study
Camargos A, Barreto S, Brant L, Ribeiro A, Dhingra L, Aminorroaya A, Bittencourt M, Figueiredo R, Khera R. Performance of contemporary cardiovascular risk stratification scores in Brazil: an evaluation in the ELSA-Brasil study. Open Heart 2024, 11: e002762. PMID: 38862252, PMCID: PMC11168182, DOI: 10.1136/openhrt-2024-002762.Peer-Reviewed Original ResearchConceptsPooled Cohort EquationsELSA-BrasilRisk scoreCardiovascular diseaseCVD eventsCommunity-based cohort studyArea under the receiver operating characteristic curveCVD risk scoreELSA-Brasil studyIncident CVD eventsMiddle-income countriesAdjudicated CVD eventsCardiovascular disease riskCVD scoreCohort EquationsNational guidelinesRisk stratification scoresWhite womenAge/sex groupsCohort studyProspective cohortLMICsSex/race groupsHigher incomeRisk discriminationDevelopment and multinational validation of an algorithmic strategy for high Lp(a) screening
Aminorroaya A, Dhingra L, Oikonomou E, Saadatagah S, Thangaraj P, Vasisht Shankar S, Spatz E, Khera R. Development and multinational validation of an algorithmic strategy for high Lp(a) screening. Nature Cardiovascular Research 2024, 3: 558-566. PMID: 39195936, DOI: 10.1038/s44161-024-00469-1.Peer-Reviewed Original ResearchElectronic health recordsAssociated with premature atherosclerotic cardiovascular diseaseElevated Lp(aHealth recordsUK BiobankPremature atherosclerotic cardiovascular diseaseMachine learning modelsAtherosclerotic cardiovascular diseaseCohort studyReal-world settingsTargeted screeningCardiovascular diseaseLearning modelsNovel targeted therapeuticsAlgorithmic strategiesCohortProbability thresholdScreeningClinical featuresValidation cohortElevated lipoproteinRisk inspectionARICLp(a
2023
Multinational patterns of second line antihyperglycaemic drug initiation across cardiovascular risk groups: federated pharmacoepidemiological evaluation in LEGEND-T2DM
Khera R, Dhingra L, Aminorroaya A, Li K, Zhou J, Arshad F, Blacketer C, Bowring M, Bu F, Cook M, Dorr D, Duarte-Salles T, DuVall S, Falconer T, French T, Hanchrow E, Horban S, Lau W, Li J, Liu Y, Lu Y, Man K, Matheny M, Mathioudakis N, McLemore M, Minty E, Morales D, Nagy P, Nishimura A, Ostropolets A, Pistillo A, Posada J, Pratt N, Reyes C, Ross J, Seager S, Shah N, Simon K, Wan E, Yang J, Yin C, You S, Schuemie M, Ryan P, Hripcsak G, Krumholz H, Suchard M. Multinational patterns of second line antihyperglycaemic drug initiation across cardiovascular risk groups: federated pharmacoepidemiological evaluation in LEGEND-T2DM. BMJ Medicine 2023, 2: e000651. PMID: 37829182, PMCID: PMC10565313, DOI: 10.1136/bmjmed-2023-000651.Peer-Reviewed Original ResearchType 2 diabetes mellitusSecond-line treatmentCardiovascular risk groupsDiabetes mellitusCardiovascular diseaseAntihyperglycaemic drugsLine treatmentRisk groupsObservational Health Data SciencesGlucagon-like peptide-1 receptor agonistsElectronic health recordsSodium-glucose cotransporter 2 inhibitorsCalendar year trendsPeptide-1 receptor agonistsUS databaseOutcomes of patientsCotransporter 2 inhibitorsAdministrative claims databaseSecond-line drugsHealth recordsSodium-glucose cotransporter-2 inhibitorsMedication useMetformin monotherapyGuideline recommendationsOutcome measuresRisk of incident cardiovascular diseases at national and subnational levels in Iran from 2000 to 2016 and projection through 2030: Insights from Iran STEPS surveys
Ebrahimi H, Masinaei M, Aminorroaya A, Aryan Z, Mehdipour P, Rostam-Abadi Y, Ahmadi N, Moghaddam S, Pishgar F, Ghanbari A, Rezaei N, Takian A, Farzadfar F. Risk of incident cardiovascular diseases at national and subnational levels in Iran from 2000 to 2016 and projection through 2030: Insights from Iran STEPS surveys. PLOS ONE 2023, 18: e0290006. PMID: 37611004, PMCID: PMC10446220, DOI: 10.1371/journal.pone.0290006.Peer-Reviewed Original ResearchConceptsCardiovascular disease riskRisk of cardiovascular diseaseNon-communicable disease risk factor surveillanceCardiovascular diseaseCVD riskWorld Health OrganizationRisk of incident cardiovascular diseaseRisk factor surveillanceFramingham 10-year CVD riskAdult Iranian populationIncident cardiovascular diseaseRisk factor modificationCardiovascular disease risk stratificationEvidence-based decisionsFramingham modelHealth policyNationally representative datasetFactor modificationRisk estimation modelIranian populationHealth OrganizationFraminghamSurvey's backgroundRiskSubnational levelUse of Smart Devices to Track Cardiovascular Health Goals in the United States
Aminorroaya A, Dhingra L, Nargesi A, Oikonomou E, Krumholz H, Khera R. Use of Smart Devices to Track Cardiovascular Health Goals in the United States. JACC Advances 2023, 2: 100544. PMID: 38094515, PMCID: PMC10718569, DOI: 10.1016/j.jacadv.2023.100544.Peer-Reviewed Original ResearchHealth goalsRisk of cardiovascular diseaseCardiovascular risk factorsNationally representative Health Information National Trends SurveyHealth Information National Trends SurveyU.S. adultsCardiovascular diseaseNational Trends SurveyRisk factors of hypertensionDigital health interventionsCardiovascular health goalsHealth-related goalsRisk of CVDFactors of hypertensionU.S. adult populationCardiovascular risk managementHigher educational attainmentLow-income individualsSmart devicesTrends SurveyImprove careHealth interventionsNational estimatesRisk factorsSurvey participantsUse of Wearable Devices in Individuals With or at Risk for Cardiovascular Disease in the US, 2019 to 2020
Dhingra L, Aminorroaya A, Oikonomou E, Nargesi A, Wilson F, Krumholz H, Khera R. Use of Wearable Devices in Individuals With or at Risk for Cardiovascular Disease in the US, 2019 to 2020. JAMA Network Open 2023, 6: e2316634. PMID: 37285157, PMCID: PMC10248745, DOI: 10.1001/jamanetworkopen.2023.16634.Peer-Reviewed Original ResearchConceptsHealth Information National Trends SurveyUS adultsExacerbate disparitiesWearable device usersCardiovascular diseaseCardiovascular healthPopulation-based cross-sectional studySelf-reported cardiovascular diseaseCardiovascular disease risk factorsNational Trends SurveyOverall US adult populationCardiovascular risk factor profileSelf-reported accessAssociated with lower useUse of wearable devicesImprove cardiovascular healthLower household incomeLower educational attainmentUS adult populationRisk factor profileNationally representative sampleCross-sectional studyProportion of adultsTrends SurveyWearable device data
2020
Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019 Update From the GBD 2019 Study
Roth G, Mensah G, Johnson C, Addolorato G, Ammirati E, Baddour L, Barengo N, Beaton A, Benjamin E, Benziger C, Bonny A, Brauer M, Brodmann M, Cahill T, Carapetis J, Catapano A, Chugh S, Cooper L, Coresh J, Criqui M, DeCleene N, Eagle K, Emmons-Bell S, Feigin V, Fernández-Solà J, Fowkes G, Gakidou E, Grundy S, He F, Howard G, Hu F, Inker L, Karthikeyan G, Kassebaum N, Koroshetz W, Lavie C, Lloyd-Jones D, Lu H, Mirijello A, Temesgen A, Mokdad A, Moran A, Muntner P, Narula J, Neal B, Ntsekhe M, de Oliveira G, Otto C, Owolabi M, Pratt M, Rajagopalan S, Reitsma M, Ribeiro A, Rigotti N, Rodgers A, Sable C, Shakil S, Sliwa-Hahnle K, Stark B, Sundström J, Timpel P, Tleyjeh I, Valgimigli M, Vos T, Whelton P, Yacoub M, Zuhlke L, Murray C, Fuster V, Group G, Roth G, Mensah G, Johnson C, Addolorato G, Ammirati E, Baddour L, Barengo N, Beaton A, Benjamin E, Benziger C, Bonny A, Brauer M, Brodmann M, Cahill T, Carapetis J, Catapano A, Chugh S, Cooper L, Coresh J, Criqui M, DeCleene N, Eagle K, Emmons-Bell S, Feigin V, Fernández-Sola J, Fowkes F, Gakidou E, Grundy S, He F, Howard G, Hu F, Inker L, Karthikeyan G, Kassebaum N, Koroshetz W, Lavie C, Lloyd-Jones D, Lu H, Mirijello A, Misganaw A, Mokdad A, Moran A, Muntner P, Narula J, Neal B, Ntsekhe M, Oliveira G, Otto C, Owolabi M, Pratt M, Rajagopalan S, Reitsma M, Ribeiro A, Rigotti N, Rodgers A, Sable C, Shakil S, Sliwa K, Stark B, Sundström J, Timpel P, Tleyjeh I, Valgimigli M, Vos T, Whelton P, Yacoub M, Zuhlke L, Abbasi-Kangevari M, Abdi A, Abedi A, Aboyans V, Abrha W, Abu-Gharbieh E, Abushouk A, Acharya D, Adair T, Adebayo O, Ademi Z, Advani S, Afshari K, Afshin A, Agarwal G, Agasthi P, Ahmad S, Ahmadi S, Ahmed M, Aji B, Akalu Y, Akande-Sholabi W, Aklilu A, Akunna C, Alahdab F, Al-Eyadhy A, Alhabib K, Alif M, Alipour V, Aljunid S, Alla F, Almasi-Hashiani A, Almustanyir S, Al-Raddadi R, Amegah A, Amini S, Aminorroaya A, Amu H, Amugsi D, Ancuceanu R, Anderlini D, Andrei T, Andrei C, Ansari-Moghaddam A, Anteneh Z, Antonazzo I, Antony B, Anwer R, Appiah L, Arabloo J, Ärnlöv J, Artanti K, Ataro Z, Ausloos M, Avila-Burgos L, Awan A, Awoke M, Ayele H, Ayza M, Azari S, Darshan B, Baheiraei N, Baig A, Bakhtiari A, Banach M, Banik P, Baptista E, Barboza M, Barua L, Basu S, Bedi N, Béjot Y, Bennett D, Bensenor I, Berman A, Bezabih Y, Bhagavathula A, Bhaskar S, Bhattacharyya K, Bijani A, Bikbov B, Birhanu M, Boloor A, Brant L, Brenner H, Briko N, Butt Z, dos Santos F, Cahill L, Cahuana-Hurtado L, Cámera L, Campos-Nonato I, Cantu-Brito C, Car J, Carrero J, Carvalho F, Castañeda-Orjuela C, Catalá-López F, Cerin E, Charan J, Chattu V, Chen S, Chin K, Choi J, Chu D, Chung S, Cirillo M, Coffey S, Conti S, Costa V, Cundiff D, Dadras O, Dagnew B, Dai X, Damasceno A, Dandona L, Dandona R, Davletov K, De la Cruz-Góngora V, De la Hoz F, De Neve J, Denova-Gutiérrez E, Molla M, Derseh B, Desai R, Deuschl G, Dharmaratne S, Dhimal M, Dhungana R, Dianatinasab M, Diaz D, Djalalinia S, Dokova K, Douiri A, Duncan B, Duraes A, Eagan A, Ebtehaj S, Eftekhari A, Eftekharzadeh S, Ekholuenetale M, Nahas N, Elgendy I, Elhadi M, El-Jaafary S, Esteghamati S, Etisso A, Eyawo O, Fadhil I, Faraon E, Faris P, Farwati M, Farzadfar F, Fernandes E, Prendes C, Ferrara P, Filip I, Fischer F, Flood D, Fukumoto T, Gad M, Gaidhane S, Ganji M, Garg J, Gebre A, Gebregiorgis B, Gebregzabiher K, Gebremeskel G, Getacher L, Obsa A, Ghajar A, Ghashghaee A, Ghith N, Giampaoli S, Gilani S, Gill P, Gillum R, Glushkova E, Gnedovskaya E, Golechha M, Gonfa K, Goudarzian A, Goulart A, Guadamuz J, Guha A, Guo Y, Gupta R, Hachinski V, Hafezi-Nejad N, Haile T, Hamadeh R, Hamidi S, Hankey G, Hargono A, Hartono R, Hashemian M, Hashi A, Hassan S, Hassen H, Havmoeller R, Hay S, Hayat K, Heidari G, Herteliu C, Holla R, Hosseini M, Hosseinzadeh M, Hostiuc M, Hostiuc S, Househ M, Huang J, Humayun A, Iavicoli I, Ibeneme C, Ibitoye S, Ilesanmi O, Ilic I, Ilic M, Iqbal U, Irvani S, Islam M, Islam R, Iso H, Iwagami M, Jain V, Javaheri T, Jayapal S, Jayaram S, Jayawardena R, Jeemon P, Jha R, Jonas J, Jonnagaddala J, Joukar F, Jozwiak J, Jürisson M, Kabir A, Kahlon T, Kalani R, Kalhor R, Kamath A, Kamel I, Kandel H, Kandel A, Karch A, Kasa A, Katoto P, Kayode G, Khader Y, Khammarnia M, Khan M, Khan N, Khan M, Khan E, Khatab K, Kibria G, Kim Y, Kim G, Kimokoti R, Kisa S, Kisa A, Kivimäki M, Kolte D, Koolivand A, Korshunov V, Laxminarayana S, Koyanagi A, Krishan K, Krishnamoorthy V, Defo B, Bicer B, Kulkarni V, Kumar G, Kumar N, Kurmi O, Kusuma D, Kwan G, La Vecchia C, Lacey B, Lallukka T, Lan Q, Lasrado S, Lassi Z, Lauriola P, Lawrence W, Laxmaiah A, LeGrand K, Li M, Li B, Li S, Lim S, Lim L, Lin H, Lin Z, Lin R, Liu X, Lopez A, Lorkowski S, Lotufo P, Lugo A, Nirmal K, Madotto F, Mahmoudi M, Majeed A, Malekzadeh R, Malik A, Mamun A, Manafi N, Mansournia M, Mantovani L, Martini S, Mathur M, Mazzaglia G, Mehata S, Mehndiratta M, Meier T, Menezes R, Meretoja A, Mestrovic T, Miazgowski B, Miazgowski T, Michalek I, Miller T, Mirrakhimov E, Mirzaei H, Moazen B, Moghadaszadeh M, Mohammad Y, Mohammad D, Mohammed S, Mohammed M, Mokhayeri Y, Molokhia M, Montasir A, Moradi G, Moradzadeh R, Moraga P, Morawska L, Velásquez I, Morze J, Mubarik S, Muruet W, Musa K, Nagarajan A, Nalini, Nangia V, Naqvi A, Swamy S, Nascimento B, Nayak V, Nazari J, Nazarzadeh M, Negoi R, Kandel S, Nguyen H, Nixon M, Norrving B, Noubiap J, Nouthe B, Nowak C, Odukoya O, Ogbo F, Olagunju A, Orru H, Ortiz A, Ostroff S, Padubidri J, Palladino R, Pana A, Panda-Jonas S, Parekh U, Park E, Parvizi M, Kan F, Patel U, Pathak M, Paudel R, Pepito V, Perianayagam A, Perico N, Pham H, Pilgrim T, Piradov M, Pishgar F, Podder V, Polibin R, Pourshams A, Pribadi D, Rabiee N, Rabiee M, Radfar A, Rafiei A, Rahim F, Rahimi-Movaghar V, Rahman M, Rahman M, Rahmani A, Rakovac I, Ram P, Ramalingam S, Rana J, Ranasinghe P, Rao S, Rathi P, Rawal L, Rawasia W, Rawassizadeh R, Remuzzi G, Renzaho A, Rezapour A, Riahi S, Roberts-Thomson R, Roever L, Rohloff P, Romoli M, Roshandel G, Rwegerera G, Saadatagah S, Saber-Ayad M, Sabour S, Sacco S, Sadeghi M, Moghaddam S, Safari S, Sahebkar A, Salehi S, Salimzadeh H, Samaei M, Samy A, Santos I, Santric-Milicevic M, Sarrafzadegan N, Sarveazad A, Sathish T, Sawhney M, Saylan M, Schmidt M, Schutte A, Senthilkumaran S, Sepanlou S, Sha F, Shahabi S, Shahid I, Shaikh M, Shamali, Shamsizadeh M, Shawon S, Sheikh A, Shigematsu M, Shin M, Shin J, Shiri R, Shiue I, Shuval K, Siabani S, Siddiqi T, Silva D, Singh J, Mtech A, Skryabin V, Skryabina A, Soheili A, Spurlock E, Stockfelt L, Stortecky S, Stranges S, Abdulkader R, Tadbiri H, Tadesse E, Tadesse D, Tajdini M, Tariqujjaman, Teklehaimanot B, Temsah M, Tesema A, Thakur B, Thankappan K, Thapar R, Thrift A, Timalsina B, Tonelli M, Touvier M, Tovani-Palone M, Tripathi A, Tripathy J, Truelsen T, Tsegay G, Tsegaye G, Tsilimparis N, Tusa B, Tyrovolas S, Umapathi K, Unim B, Unnikrishnan B, Usman M, Vaduganathan M, Valdez P, Vasankari T, Velazquez D, Venketasubramanian N, Vu G, Vujcic I, Waheed Y, Wang Y, Wang F, Wei J, Weintraub R, Weldemariam A, Westerman R, Winkler A, Wiysonge C, Wolfe C, Wubishet B, Xu G, Yadollahpour A, Yamagishi K, Yan L, Yandrapalli S, Yano Y, Yatsuya H, Yeheyis T, Yeshaw Y, Yilgwan C, Yonemoto N, Yu C, Yusefzadeh H, Zachariah G, Bin Zaman S, Zaman M, Zamanian M, Zand R, Zandifar A, Zarghi A, Zastrozhin M, Zastrozhina A, Zhang Z, Zhang Y, Zhang W, Zhong C, Zou Z, Zuniga Y, Murray C, Fuster V. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019 Update From the GBD 2019 Study. Journal Of The American College Of Cardiology 2020, 76: 2982-3021. PMID: 33309175, PMCID: PMC7755038, DOI: 10.1016/j.jacc.2020.11.010.Peer-Reviewed Original ResearchConceptsGlobal Burden of DiseaseDisability-adjusted life yearsIschemic heart diseaseCardiovascular disease burdenHigh-income countriesCardiovascular diseaseGlobal burdenPrevalent casesEstimates of population healthBurden of cardiovascular diseaseAge-standardized ratesCardiovascular disease deathsRates of cardiovascular diseaseCVD burdenRisk factorsGlobal burden of cardiovascular diseaseCases of ischemic heart diseaseBurden of diseaseSustainable Development Goal 3Cases of strokeGBD 2019 studyTotal cardiovascular diseaseTotal CVD burdenPopulation healthNoncommunicable diseasesOpium and cardiovascular health: A devil or an angel?
Roayaei P, Aminorroaya A, Vasheghani-Farahani A, Oraii A, Sadeghian S, Poorhosseini H, Masoudkabir F. Opium and cardiovascular health: A devil or an angel? Indian Heart Journal 2020, 72: 482-490. PMID: 33357635, PMCID: PMC7772609, DOI: 10.1016/j.ihj.2020.10.003.Peer-Reviewed Original ResearchConceptsOpium consumptionCardiovascular diseaseEffects of opium consumptionMedical staffChronic diseasesIllicit drug consumptionStable coronary artery diseaseHigher consumptionConsumption of opiumRisk factorsAcute coronary syndromeCoronary artery diseaseAbused substancesTraditional beliefsDiabetes mellitusCoronary syndromeDrug consumptionDiabetic patientsArtery diseaseHealthy individualsAmeliorative effectDiseaseStaffTobaccoAnti-modified citrullinated vimentin antibody: a novel biomarker associated with cardiac systolic dysfunction in patients with rheumatoid arthritis
Norouzi S, Javinani A, Aminorroaya A, Masoumi M. Anti-modified citrullinated vimentin antibody: a novel biomarker associated with cardiac systolic dysfunction in patients with rheumatoid arthritis. BMC Cardiovascular Disorders 2020, 20: 390. PMID: 32847506, PMCID: PMC7448352, DOI: 10.1186/s12872-020-01676-x.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionCardiac systolic dysfunctionCardiovascular diseaseSystolic dysfunctionRheumatoid arthritisReduced left ventricular ejection fractionPredictors of left ventricular ejection fractionAnti-modified citrullinated vimentinEchocardiographic parameters of systolicDisease Activity Score-28Anti-MCV levelsParameters of systolicAssociation of autoantibodiesVentricular ejection fractionConcomitant cardiovascular diseaseExclusion of patientsSusceptibility to cardiovascular diseaseReceiver operating characteristic curveDuration of diseaseCardiovascular disease risk factorsAnti-citrullinated proteinFramingham risk scoreCross-sectional studyTransthoracic echocardiographyDiastolic dysfunction