Marine Cacheux

Marine Cacheux is an Associate Research Scientist whose research has been focused on investigating the mechanisms underlying cardiac and skeletal muscle physiology and pathophysiology. Specifically, her work is dedicated to the study of ion channels and calcium cycling proteins in striated muscle in different pathological contexts. A key interest has been to investigate mechanisms underlying excitation-Contraction Coupling in health and disease, with a focus on the genes and proteins that are directly involved in the handling of intracellular calcium fluxes. Marine has also been interested in the role of calcium signaling in the regulation of cardiac electrophysiological properties and arrhythmias. Her current research is focused on understanding the structural and arrhythmic mechanisms underlying the development of heart failure and sudden cardiac death in the context of a multitude of acquired and inherited conditions. She has extensive expertise in the use of human and mouse primary cells as well as in vivo mouse models mimicking various muscle diseases to study the pathological consequences of gene mutations and altered protein function.