2023
α-Synuclein colocalizes with AP180 and affects the size of clathrin lattices
Vargas K, Colosi P, Girardi E, Park J, Harmon L, Chandra S. α-Synuclein colocalizes with AP180 and affects the size of clathrin lattices. Journal Of Biological Chemistry 2023, 299: 105091. PMID: 37516240, PMCID: PMC10470054, DOI: 10.1016/j.jbc.2023.105091.Peer-Reviewed Original ResearchConceptsClathrin punctaClathrin assemblyEndocytic accessory proteinsΑ-synucleinPresynaptic membraneSynaptic vesicle cyclingImmuno-electron microscopyClathrin structuresAccessory proteinsClathrin latticesMembrane curvatureVesicle cyclingCell membranePresynaptic proteinsLipid monolayer systemProteinΓ-synucleinMembranePunctaAssemblyRelocalizesClathrinColocalizesVesicle sizeDeletionα-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease
Martin-Lopez E, Vidyadhara D, Liberia T, Meller S, Harmon L, Hsu R, Spence N, Brennan B, Han K, Yücel B, Chandra S, Greer C. α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease. Journal Of Neuroscience 2023, 43: 1051-1071. PMID: 36596700, PMCID: PMC9908323, DOI: 10.1523/jneurosci.1526-22.2022.Peer-Reviewed Original ResearchConceptsΑ-syn tg miceΑ-Syn pathologyOlfactory bulb neurogenesisProjection neuronsParkinson's diseaseOlfactory dysfunctionMutant α-synucleinOlfactory deficitsOlfactory pathwaySyn pathologyBehavioral deficitsMouse modelΑ-synucleinOB granule cellsΑ-synuclein pathologyOlfactory systemMonths of ageReduced neurogenesisFunctional deficitsPeriglomerular cellsMotor progressionPathologic changesMultiple symptomsSynaptic terminalsGranule cells
2017
Synucleins Have Multiple Effects on Presynaptic Architecture
Vargas KJ, Schrod N, Davis T, Fernandez-Busnadiego R, Taguchi YV, Laugks U, Lucic V, Chandra SS. Synucleins Have Multiple Effects on Presynaptic Architecture. Cell Reports 2017, 18: 161-173. PMID: 28052246, PMCID: PMC5510332, DOI: 10.1016/j.celrep.2016.12.023.Peer-Reviewed Original ResearchConceptsParkinson's diseasePD mutationsPresynaptic proteinsSynucleinΑ-synucleinPresynaptic architectureUltrastructural changesAbundant presynaptic proteinPathological functionsPresynaptic cytomatrixImportant orchestratorsProtein phosphorylation changesDiseaseMultiple effectsActive zonePrevious findingsPD mutantsPathogenesisNeurotransmissionSynapse architecturePhosphorylation changesMutationsMice
2014
Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis
Vargas KJ, Makani S, Davis T, Westphal CH, Castillo PE, Chandra SS. Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis. Journal Of Neuroscience 2014, 34: 9364-9376. PMID: 25009269, PMCID: PMC4087213, DOI: 10.1523/jneurosci.4787-13.2014.Peer-Reviewed Original ResearchConceptsSV endocytosisShares high sequence identitySynaptic vesicle endocytosisFamilial PD genesHigh sequence identitySynaptic vesicle traffickingΑ-synucleinVesicle traffickingVesicle endocytosisΓ-synucleinMouse αSequence identityNull culturesBiochemical experimentsPD genesEndocytosisEarly stepsAcidic lipidsPresynaptic proteinsProteinNormal functionPrecise siteSynucleinParkinson's diseaseGenesSynucleins☆
Vargas K, Chandra S. Synucleins☆. 2014 DOI: 10.1016/b978-0-12-801238-3.04785-1.Peer-Reviewed Original ResearchVertebrate-specific gene familyHuman α-synuclein geneSynaptic vesicle cyclingGene familyNormal physiological functionFamilial Parkinson's diseaseVesicle cyclingΑ-synucleinKDa proteinPhysiological functionsΒ-synucleinΑ-synuclein geneNeurodegenerative disordersProteinΓ-synucleinPresynaptic terminalsSynuclein
2009
Synucleins
Chandra S. Synucleins. 2009, 833-837. DOI: 10.1016/b978-008045046-9.01354-1.Peer-Reviewed Original Research
2008
Chapter 22 α-Synuclein, CSPα, SNAREs and Neuroprotection in vivo
Chandra S, Südhof T. Chapter 22 α-Synuclein, CSPα, SNAREs and Neuroprotection in vivo. 2008, 295-308. DOI: 10.1016/b978-0-12-374028-1.00022-1.Peer-Reviewed Original ResearchΑ-synucleinDopamine replacement therapyMouse α-synucleinPathological functionsStriatal terminalsReplacement therapyPD treatmentNormal physiological functionSynaptic connectionsPresynaptic proteinsNeurodegenerative phenotypeΑ-deletionCysteine string proteinToxic gainAmino acid changesPhysiological functionsAcid changesNeuroprotectionPathogenesisTherapyFindingsNeurodegeneration