2017
Lipid transport by TMEM24 at ER–plasma membrane contacts regulates pulsatile insulin secretion
Lees JA, Messa M, Sun EW, Wheeler H, Torta F, Wenk MR, De Camilli P, Reinisch KM. Lipid transport by TMEM24 at ER–plasma membrane contacts regulates pulsatile insulin secretion. Science 2017, 355 PMID: 28209843, PMCID: PMC5414417, DOI: 10.1126/science.aah6171.Peer-Reviewed Original ResearchConceptsER–plasma membrane contactsLipid transportLipid-binding modulesMembrane contactPhosphoinositide signalingMembrane proteinsPrecursor phosphatidylinositolProtein 24Reversible localizationEndoplasmic reticulumTMEM24Β-cellsPhosphatidylinositolInsulin secretionCalcium oscillationsCytosolic calciumDephosphorylationType II diabetesPhosphorylationSignalingProteinReticulumSecretionII diabetesTransport
1994
Formation of synaptic vesicles
Mundigl O, De Camilli P. Formation of synaptic vesicles. Current Opinion In Cell Biology 1994, 6: 561-567. PMID: 7986534, DOI: 10.1016/0955-0674(94)90077-9.Peer-Reviewed Original ResearchConceptsSynaptic vesiclesNew synaptic vesiclesSV membranesTransport vesiclesEvolutionary originNon-peptide neurotransmittersMembrane proteinsSecretory organellesFocal signalingVesiclesExocytosisMolecular compositionCellsGamma-aminobutyric acidOrganellesSignalingNerve cellsProteinDepolarization-induced Ca2PathwaySignificant progressNeurotransmittersMembraneAssemblyNerve terminals
1993
Exo-Endocytotic Recycling of Synaptic Vesicles in Developing Neurons
Matteoli M, De Camilli P. Exo-Endocytotic Recycling of Synaptic Vesicles in Developing Neurons. 1993, 153-163. DOI: 10.1007/978-1-4757-9542-4_17.Peer-Reviewed Original ResearchLarge dense-core vesiclesSynaptic vesiclesExo-endocytotic recyclingNon-peptide neurotransmittersIntercellular signalingRegulated secretionLarge organellesElectron-dense coreSmall vesiclesDense-core vesiclesVesiclesCore vesiclesExocytosisNeurotransmitter moleculesSynaptic transmissionOrganellesOrgandiesSignalingNeuroactive peptidesNeurotransmittersNeuronsPeptides