2023
PET Imaging of Rho‐Associated Protein Kinase 2 in A Mouse Model of Alzheimer’s Disease
Zheng C, Nicholson L, Chen B, Toyonaga T, Liu M, Strittmatter S, Carson R, Huang Y, Cai Z. PET Imaging of Rho‐Associated Protein Kinase 2 in A Mouse Model of Alzheimer’s Disease. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.081695.Peer-Reviewed Original ResearchAPP/PS1 micePS1 miceWT miceCentral nervous systemTime-activity curvesAlzheimer's diseaseAPP/PS1 transgenic miceAPP/PS1 transgenic AD miceMouse brainAge-matched WT controlsPS1 transgenic miceAPP/PS1Transgenic AD miceDynamic PET imaging dataROCK2 protein expressionAD drug discoveryHigh tracer uptakeMin post injectionPET imaging resultsExpression levelsReference tissue model 2PET imaging dataProtein expression levelsAD miceRegional time-activity curves
2017
Regulated viral BDNF delivery in combination with Schwann cells promotes axonal regeneration through capillary alginate hydrogels after spinal cord injury
Liu S, Sandner B, Schackel T, Nicholson L, Chtarto A, Tenenbaum L, Puttagunta R, Müller R, Weidner N, Blesch A. Regulated viral BDNF delivery in combination with Schwann cells promotes axonal regeneration through capillary alginate hydrogels after spinal cord injury. Acta Biomaterialia 2017, 60: 167-180. PMID: 28735026, DOI: 10.1016/j.actbio.2017.07.024.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorHost spinal cordSpinal cord injurySpinal cordLesion siteSchwann cellsBDNF expressionCord injuryNeurotrophic factorAxonal regenerationBDNF deliveryExpression of BDNFGraft/host interfaceSpinal cord lesion siteAdult mammalian central nervous systemHost/graft interfaceSpinal cord transectionMammalian central nervous systemRat spinal cordCentral nervous systemCaudal spinal cordCaudal injectionHemisection lesionCord transectionCell transplantation