1997
Pathogenesis of Tourette's Syndrome
Leckman J, Peterson B, Anderson G, Arnsten A, Pauls D, Cohen D. Pathogenesis of Tourette's Syndrome. Journal Of Child Psychology And Psychiatry 1997, 38: 119-142. PMID: 9232461, DOI: 10.1111/j.1469-7610.1997.tb01508.x.Peer-Reviewed Original ResearchMeSH KeywordsBasal GangliaBrainBrain MappingCerebral CortexChildHumansNerve NetNeurotransmitter AgentsPhenotypeTourette Syndrome
1995
Guanfacine Treatment of Comorbid Attention-Deficit Hyperactivity Disorder and Tourette's Syndrome: Preliminary Clinical Experience
CHAPPELL P, RIDDLE M, SCAHILL L, LYNCH K, SCHULTZ R, ARNSTEN A, LECKMAN J, COHEN D. Guanfacine Treatment of Comorbid Attention-Deficit Hyperactivity Disorder and Tourette's Syndrome: Preliminary Clinical Experience. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1140-1146. PMID: 7559307, DOI: 10.1097/00004583-199509000-00010.Peer-Reviewed Original ResearchConceptsYale Global Tic Severity ScaleAttention deficit hyperactivity disorderTourette syndromeContinuous Performance TestHyperactivity disorderOpen-label studyCommon side effectsSeverity of motorComorbid attention deficit hyperactivity disorderSafe alternative therapySignificant decreaseTic Severity ScalePreliminary clinical experienceMajority of subjectsConners' Parent Rating ScaleTransient sedationControlled TrialsAlternative therapiesSedative effectsGuanfacine treatmentPhonic ticsSeverity ScaleSide effectsStimulant medicationTic severity