2007
Norepinephrine and cognitive disorders
Arnsten A. Norepinephrine and cognitive disorders. 2007, 408-435. DOI: 10.1017/cbo9780511544156.015.Peer-Reviewed Original ResearchNoradrenergic drugsCentral nervous system norepinephrineNervous system norepinephrineRole of norepinephrineNoradrenergic neuronsCNS diseaseTherapeutic effectCognitive disordersNorepinephrineNeurological disordersNorepinephrine's roleBrain diseasesNew disease indicationsChemical neurotransmittersDisease indicationsDrugsDiseasePharmacologyDisordersTherapeuticsBasic biologyMolecular biologyNeurotransmittersNeuronsBrain
1999
Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder
Southwick S, Bremner J, Rasmusson A, Morgan C, Arnsten A, Charney D. Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder. Biological Psychiatry 1999, 46: 1192-1204. PMID: 10560025, DOI: 10.1016/s0006-3223(99)00219-x.Peer-Reviewed Original ResearchConceptsRole of norepinephrineClinical studiesNorepinephrine's roleTrauma-related alterationsRe-experiencing symptomsFear-provoking stimuliTreatment of PTSDPosttraumatic stress disorderChronic uncontrollable stressPharmacologic treatmentClinical findingsNeuronal reactivityIntrusive memoriesAdrenergic blockersEnhanced encodingSelective attentionPreclinical studiesReceptor sensitivityAversive eventsNorepinephrineTraumatic stressNovel stimuliStress disorderMAO inhibitorsUncontrollable stress