Alvaro Duque, PhD
Senior Research ScientistCards
About
Research
Publications
2026
The MacBrain Resource Center (MBRC) rhesus macaque postnatal brain histology datasets: Enabling new discoveries through NHP tissue and digital data Repositories
Mendoza‐Silva V, Greene L, Burke E, Canales C, Chocarro J, Lanciego J, Kurrey K, Barello P, Nusir A, Kabbani N, Rockland K, Datta D, Arellano J, Arnsten A, Morozov Y, Ahmed B, Molnár Z, Zeiss C, Rakic P, Duque A. The MacBrain Resource Center (MBRC) rhesus macaque postnatal brain histology datasets: Enabling new discoveries through NHP tissue and digital data Repositories. Journal Of Anatomy 2026 PMID: 42237680, DOI: 10.1111/joa.70183.Peer-Reviewed Original ResearchThe MacBrain Resource Center (MBRC) rhesus macaque embryonic brain histology datasets
Mendoza‐Silva V, Burke E, Greene L, Rodov M, Kopić J, Barello P, Morozov Y, Moriya‐Ito K, Ohtaka‐Maruyama C, Krsnik Z, Rakic P, Duque A. The MacBrain Resource Center (MBRC) rhesus macaque embryonic brain histology datasets. Journal Of Anatomy 2026, 10.1111/joa.70161. PMID: 42015502, PMCID: PMC13398914, DOI: 10.1111/joa.70161.Peer-Reviewed Original ResearchLamination of primary visual cortex in the macaque: Layer 5 subdivisions
Ahmed B, Duque A, Rakic P, Molnár Z. Lamination of primary visual cortex in the macaque: Layer 5 subdivisions. Journal Of Anatomy 2026 PMID: 41958118, DOI: 10.1111/joa.70137.Peer-Reviewed Original ResearchHigh-resolution in utero SV2A PET imaging of the nonhuman primate brain using the NeuroEXPLORER
Mehta S, Sun H, Micali N, Holden D, Fowles K, Rossano S, Zhang J, Ma C, Han P, Lee W, Duque A, Rakic P, Groman S, Carson R, Scheinost D, Toyonaga T. High-resolution in utero SV2A PET imaging of the nonhuman primate brain using the NeuroEXPLORER. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2026, 0271678x261429044. PMID: 41823342, PMCID: PMC12987752, DOI: 10.1177/0271678x261429044.Peer-Reviewed Original ResearchHuman-specific features of the cerebellum and ZP2-regulated synapse development
Kim S, Cherskov A, Sindhwani A, Choi S, Kim H, Li M, Zhang M, Mato-Blanco X, Liu Y, Micali N, Young D, Estacion M, Zhang Y, Ruiz-Jiménez J, Nadkarni A, Luria V, Sindhu S, Chatterjee I, Shibata A, Liang D, Cho H, Park S, Spajic A, Kovner R, Glavan M, Chen R, Risgaard R, Li X, Pochareddy S, Karger A, Huttner A, Morozov Y, Daadi E, Colantuoni C, Gobeske K, Ely J, Hof P, Daadi M, Sherwood C, Duque A, Ma S, Sousa A, Waxman S, Rakic P, Santpere G, Sanders S, Sestan N. Human-specific features of the cerebellum and ZP2-regulated synapse development. Cell 2026, 189: 1802-1819.e28. PMID: 41819103, DOI: 10.1016/j.cell.2026.02.014.Peer-Reviewed Original Research
2025
Neuropathology and Biomarker Correlates of Late Onset Alzheimer’s Disease in Aged Old World Monkeys
Zeiss C, Duque A, Huttner A. Neuropathology and Biomarker Correlates of Late Onset Alzheimer’s Disease in Aged Old World Monkeys. Toxicologic Pathology 2025, 53: 682-694. PMID: 41257351, PMCID: PMC12638005, DOI: 10.1177/01926233251388069.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsDecreased cholinergic neuronal firing in a mouse model of temporal lobe seizures with impaired consciousness
Liu S, Paszkowski P, Qu J, Sieu L, Liu J, Valcarce‐Aspegren M, Khan W, McGill S, Lee D, Duque A, Blumenfeld H. Decreased cholinergic neuronal firing in a mouse model of temporal lobe seizures with impaired consciousness. Epilepsia 2025, 66: 5067-5081. PMID: 40956639, DOI: 10.1111/epi.18625.Peer-Reviewed Original ResearchPerspective Chapter: From Embryonic Archives to Translational Insights – Reusing Nonhuman Primate Brain Data to Decode Development and Reduce Animal Sacrifice
Duque A, Barello P, Greene L, Burke E, Mendoza-Silva V, M. Morozov Y, Rakic P. Perspective Chapter: From Embryonic Archives to Translational Insights – Reusing Nonhuman Primate Brain Data to Decode Development and Reduce Animal Sacrifice. 2025 DOI: 10.5772/intechopen.1011631.BooksEarly developmental origins of cortical disorders modeled in human neural stem cells
Mato-Blanco X, Kim S, Jourdon A, Ma S, Choi S, Giani A, Paredes M, Tebbenkamp A, Liu F, Duque A, Vaccarino F, Sestan N, Colantuoni C, Rakic P, Santpere G, Micali N. Early developmental origins of cortical disorders modeled in human neural stem cells. Nature Communications 2025, 16: 6347. PMID: 40634286, PMCID: PMC12241556, DOI: 10.1038/s41467-025-61316-w.Peer-Reviewed Original ResearchHigher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques
Joyce M, Ivanov T, Krienen F, Mitchell J, Ma S, Inoue W, Nandy A, Datta D, Duque A, Arellano J, Gupta R, Gonzalez-Burgos G, Lewis D, Sestan N, McCarroll S, Martinez-Trujillo J, Froudist-Walsh S, Arnsten A. Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques. Communications Biology 2025, 8: 974. PMID: 40594842, PMCID: PMC12214923, DOI: 10.1038/s42003-025-08297-0.Peer-Reviewed Original Research