Albert C Shaw, MD, PhD, AB

Associate Professor of Medicine (Infectious Diseases)

Research Interests

Aging; DNA Repair; Immune System; Immunity, Innate; Influenza Vaccines; DNA Topoisomerases; Toll-Like Receptors; Presenilins; Infectious Disease Medicine

Research Organizations

Internal Medicine: CPIRT - Pulmonary Infection Research and Treatment | Infectious Diseases | Rheumatic Diseases Research Core


Yale Center for Research on Aging (Y-Age)

Office of Cooperative Research

Research Summary

Research in the Shaw laboratory is directed toward understanding the mechanisms underlying the functional decline of the immune system with aging. Ongoing projects include studies on the function of presenilins—proteins implicated in the pathogenesis of Alzheimer's Disease—in cells of the immune system. In addition, the laboratory is examining the role of mammalian topoisomerases in the control of DNA repair, genomic stability and age-related alterations in the immune system. Finally, we are engaged in ongoing studies in humans that seek to elucidate age-related changes in the innate immune system (such as the Toll-like receptors), and to correlate such changes with responsiveness to vaccines (which decreases substantially in older adults) and susceptibility to infectious diseases.

Specialized Terms: Mechanisms underlying the functional decline of the immune system with aging

Selected Publications

Full List of PubMed Publications

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Contact Info

Albert C Shaw, MD, PhD, AB
Patient Care Location
Yale Infectious DiseasesYale New Haven Hospital
20 York Street

New Haven, CT 06510
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Mailing Address
Infectious DiseasesPO Box 208022
300 Cedar Street

New Haven, CT 06520-8022