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Romina Fiorotto, PhD

Assistant Professor; Associate Director, Cellular & Molecular Physiology

Contact Information

Romina Fiorotto, PhD

Mailing Address

  • Internal Medicine

    PO Box 208019, 333 Cedar Street

    New Haven, CT, 06520-8056

    United States

Appointments

Education & Training

  • Visiting Scientist
    Yale University School of Medicine (2005)
  • Postdoctoral fellow
    University of Padova (2005)
  • PhD
    University of Parma, Hepatic Pathophysiology (2005)
  • BACH OTHER
    University of Padova, Biological Sciences (1999)

Activities

  • Epithelial innate immunity and microbiota: a gut-biliary link in cystic fibrosis cholangiopathy
    New Orleans, United States 2022
  • Innate immunity and the gut liver axis in cholangiopathies: The case for cystic fibrosis related liver disease
    Florence, Italy 2022
  • Multi-omics Approaches for Cholestatic Liver Diseases: From Diagnosis to Disease Mechanisms and Precision Medicine
    New Haven, United States 2022
  • Organoids to Model Liver Disease
    The Liver Meeting Digital Experience. Meet The Expert session. 2020
  • Inhibition of Src tyrosine kinase restores CFTR function in cystic fibrosis cholangiocytes derived from human induced pluripotent stem cells (iPSC) and improves the response to CFTR potentiators and correctors used in therapy.
    Oslo, Norway 2017
  • Expansion and polarization of cholangiocytes from human induced pluripotent stem cells (iPSc).
    Ascot, United Kingdom 2016
  • Post-translational regulation of Polycystin 2 (PC2) expression as a novel mechanism of cholangiocyte reaction to biliary damage and repair.
    Vienna, Austria 2015
  • CFTR controls a membrane multi-protein complex that regulates cholangiocyte c-src tyrosine kinase activity and tlr4 signaling: implications for cystic fibrosis liver disease (CFLD).
    London, United Kingdom 2014
  • CFTR controls TLR4 responses of the biliary epithelium by regulating c-Src tyrosine kinase activation.
    Atlanta, United States 2014
  • Stimulation of PPAR-γ reduces NFkB-dependent inflammation in cystic fibrosis biliary epithelium.
    Atlanta, United States 2014
  • The Cystic Fibrosis Conductance Regular (CFTR) controls c-Src tyrosine kinase signaling and regulates innate immunity and epithelial polarity in cholangiocytes.
    Boston, United States 2014
  • Stimulation of PPAR-γ reduces NFkB-dependent inflammation in cystic fibrosis biliary epithelium.
    Boston, United States 2014
  • Notch-Mediated Epithelial/Mesenchymal Interaction Influences Non_Alcoholic Steatohepatitis (NASH) Progression.
    Boston, United States 2014
  • Post-translational regulation of Polycystin 2 (PC2) protein expression by ubiquitination and autophagy as a novel mechanism of cholangiocyte repair and reaction to biliary damage.
    Boston, United States 2014
  • CXCL1 and CXCL10 secretion by fibrocystin-defective cholangiocytes recruits peribiliary fibrocytes in congenital hepatic fibrosis.
    Amsterdam, Netherlands 2013
  • Src tyrosine kinase mediates the increased TLR4-dependent stimulation of innate immunity responses to endotoxins in Cftr-defective cholangiocytes.
    Washington, United States 2013
  • β-catenin-mediated CXCL1 and CXCL10 secretion by fibrocystin-defective cholangiocytes regulates peribiliary recruitment of fibrocytes in congenital hepatic fibrosis. Hepatology 58(4) 573A.
    Washington, United States 2013
  • Cyclic-AMP-dependent, Rac1-mediated nuclear translocation of p-Ser675β -catenin, a novel signaling defect in Congenital Hepatic Fibrosis (CHF) and Caroli’s Disease (CD).
    Boston, United States 2012
  • PKA-dependent p-ser-675β-catenin phosphorylation increases cholangiocyte motility in Pkhddel4/del4 mice, a model of fibropolycystic liver diseases caused by defective fibrocystin function.
    Berlin, Germany 2011
  • Inappropriate Store-Operated c-AMP production links altered endoplasmic reticulum Ca2+ homeostasis to Erk/Vegf signaling in trpp2-defective cholangiocytes in a mouse model of polycystic liver disease.
    Berlin, Germany 2011
  • Sorafenib paradoxically activates the Raf/Mek/Erk signaling in mice with polycystic liver disease (PLD) caused by conditional deletion of polycystin-2.
    San Francisco, United States 2011
  • Progenitor cell activation and liver repair is altered in Notch2- and RBP-jK- defective mice exposed to cholestatic injuries
    Vienna, Austria 2010
  • Lack of CFTR affects the innate immunity of the biliary epithelium and determines a TLR4/NF-κB-mediated inflammatory response.
    Vienna, Austria 2010
  • Defective progenitor cells activation and biliary tubule formation in liver conditional RBP-Jk-KO mice exposed to cholestatic injuries reveals a key role for Notch signaling in liver repair. FASEB Research Summer Conference.
    Snowmass, United States 2010
  • Altered regulation of TLR4 in the biliary epithelium of CFTR-defective mice determines an inflammatory phenotype and causes liver damage after induction of DSS colitis.
    Boston, United States 2010
  • Activation of Store Operated Cyclic Amp signaling mediates VEGF overexpression in polycystin-2 defective cholangiocytes.
    Boston, United States 2010
  • Rapamycin inhibits cyst growth, IGF-1- mediated VEGF secretion and cell proliferation in polycystin-2 defective mice, a model for PLD associated to ADPKD
    Copenhagen, Denmark 2009
  • IGF-1 stimulates liver cysts growth in policystin-2 defective mice trough an mTOR and VEGF-mediated –mechanisms that can be inhibited in vivo by treatment with Rapamycin
    Boston, United States 2009
  • S100A4, an early marker of epithelial-mesenchymal transition, is associated with poor prognosis and strong metastatic potential in cholangiocarcinoma
    Boston, United States 2009
  • Inhibition of autocrine VEGF signaling reduces ERK1/2 activation and cyst growth in polycystin-2 defective mice
    San Francisco, United States 2008
  • Evidence for epithelial-mesenchymal transition in human cholangiocarcinoma
    San Francisco, United States 2008
  • Arterial and peribiliary vasculogenesis during liver development is modulated by angiogenic growth factors expressed by ductal plate cells and hepatoblasts
    Barcelona, Spain 2007
  • Angiogenic growth factors secreted by liver epithelial cells modulate arterial vasculogenesis during human liver development.
    Boston, United States 2006
  • UDCA stimulates fluid secretion in mice bile ducts trough a CFTR- and PKCα/PKCε-dependent mechanism.
    Boston, United States 2004
  • Altered Jagged-1/Notch signaling influences liver repair mechanisms in Alagille Syndrome
    San Francisco, United States 2004
  • Defective progenitor cells activation and biliary tubule formation in liver conditional RBP-Jk-knock out mice exposed to cholestatic injuries reveals a key role for Notch signaling in liver repair.
    Boston, United States 0001

Honors & Recognition

AwardAwarding OrganizationDate
Best Abstract AwardEuropean Association for the Study of the Liver2017
American Liver Foundation Scholar Award2011
Samuel D Kushlan Junior Faculty Award2009
Italian Cystic Fibrosis Foundation Scholar Award2005

Professional Service

OrganizationRoleDate
British Journal of PharmacologyReviewer2021
Scientific ReportsReviewer2021
DBT/Welcome Trust India AllianceAd-hoc reviewer2021
Cholestatic & Autoimmune Liver Diseases SIGCommittee Member2020 - Present
AASLDSteering Committee Member, Cholestatic & Autoimmune Liver Diseases SIG2020 - Present
AASLD FoundationAward Committee Member2019 - Present
Yale Liver CenterAssociate Program Director2018 - Present
ISSNAFAd-hoc reviewer2017 - Present
AASLDMember2014 - Present
PSI FoundationAd-hoc reviewer2012 - 2013
European Association for the Study of Liver DiseasesMember2010 - Present
American Gastroenterological AssociationMember2010 - Present
Italian Association for the Study of the Liver DiseasesMember2004 - Present

Departments & Organizations