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Higher HIV viral load and lower CD4 count linked to liver cancer risk
The researchers analysed electronic medical records of participants in the Veterans Aging Cohort Study, an ongoing study of HIV-positive US veterans, who had available viral load and CD4 count measurements and at least six months of follow-up between 1999 and 2015. Those with pre-existing HCC were excluded. As a measure of liver fibrosis, they used the non-invasive Fibrosis-4 (FIB-4) index, which incorporates patient age, platelet count, and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) liver enzyme levels; scores above 3.25 suggest advanced fibrosis or cirrhosis.
Source: aidsmap