Evaluating the impact of stratification on the power and cross-arm balance of randomized phase 2 clinical trials.
Moseley A, LeBlanc M, Freidlin B, Shallis R, Zeidan A, Sallman D, Erba H, Little R, Othus M. Evaluating the impact of stratification on the power and cross-arm balance of randomized phase 2 clinical trials. Clinical Trials 2025, 17407745241304065. PMID: 39815460, DOI: 10.1177/17407745241304065.Peer-Reviewed Original ResearchStratified analysisSample sizeRandomization ratioRandomization methodType 1 errorStratified block randomizationRandomized clinical trialsUnstratified analysisBlock randomizationStratification factorsClinical trialsStratification subgroupsTrialsPhase 2 trialDecreased powerSubgroupsRandomized phase 2 clinical trialFactorsRandomizationRandomized phase 2 trial