Mucinous Differentiation Correlates with Absence of EGFR Mutation and Presence of KRAS Mutation in Lung Adenocarcinomas with Bronchioloalveolar Features
Finberg KE, Sequist LV, Joshi VA, Muzikansky A, Miller JM, Han M, Beheshti J, Chirieac LR, Mark EJ, Iafrate AJ. Mucinous Differentiation Correlates with Absence of EGFR Mutation and Presence of KRAS Mutation in Lung Adenocarcinomas with Bronchioloalveolar Features. Journal Of Molecular Diagnostics 2007, 9: 320-326. PMID: 17591931, PMCID: PMC1899415, DOI: 10.2353/jmoldx.2007.060182.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, Bronchiolo-AlveolarAdenocarcinoma, MucinousAgedAged, 80 and overCell DifferentiationDisease ProgressionDNA Mutational AnalysisFemaleGene DosageGenes, erbB-1Genes, rasHumansIn Situ Hybridization, FluorescenceLung NeoplasmsMaleMiddle AgedMutationPrognosisRetrospective StudiesConceptsEpidermal growth factor receptor (EGFR) geneEGFR mutationsBronchioloalveolar carcinomaKRAS mutationsLung adenocarcinomaBronchioloalveolar featuresKRAS codon 12Mucinous patternNonmucinous tumorsClinical responseMucinous histologyMucinous tumorsGrowth factor receptor geneMucinous adenocarcinomaHistopathological featuresNonmucinous adenocarcinomaMucinous morphologyMucinous differentiationAdenocarcinomaFactor receptor geneCodon 12Kinase inhibitorsTumorsReceptor geneTKIs